A5100629025- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Neurosurgical Procedures and Complications
- Photorefractive and Nonlinear Optics
- Photonic and Optical Devices
- Liquid Crystal Research Advancements
- Parkinson's Disease Mechanisms and Treatments
- Spinal Hematomas and Complications
- Cardiac Valve Diseases and Treatments
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Neurobiology and Insect Physiology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Infective Endocarditis Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Genetics, Aging, and Longevity in Model Organisms
- Dialysis and Renal Disease Management
- Mitochondrial Function and Pathology
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
Taichung Veterans General Hospital
2016-2025
National Cheng Kung University Hospital
2020-2025
National Chung Hsing University
2014-2024
National Yang Ming Chiao Tung University
2014-2024
Radiation Oncology Associates
2024
National Health Research Institutes
2016-2024
Taipei Veterans General Hospital
2006-2024
Waseda University
2023-2024
En Chu Kong Hospital
2024
Chang Gung Memorial Hospital
2019-2023
Abstract Background Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson’s disease (PD). Functional analysis genes linked PD revealed that E3 ligase Parkin mitochondrial kinase PINK1 are important factors for quality control. phosphorylates activates Parkin, which turn ubiquitinates proteins priming them mitochondrion itself degradation. However, it is unclear whether dysregulated...
The triglyceride-glucose (TyG) index has recently been proposed as a reliable marker of insulin resistance. There is insufficient evidence to verify that the TyG correlated with functional outcomes and hemorrhagic transformation in patients stroke treated intravenous thrombolysis (IVT).We designed multicenter cohort study, which enrolled acute ischemic IVT between December 2004 2016. was divided into tertiles calculated on continuous scale. Unfavorable were defined by modified Rankin Scale...
The Taiwan Society of Cardiology (TSOC) and Plastic Surgery (TSPS) have collaborated to develop a joint consensus for the management patients with advanced vascular wounds. taskforce comprises experts including preventive cardiologists, interventionists, cardiovascular plastic surgeons. focuses on addressing challenges in diagnosing, treating, managing complex wounds; incorporates perfusion evaluation wound care team; highlights importance cross-disciplinary teamwork. aim this is manage...
Background and Purpose: As populations age, there is an increasing need to optimize endovascular treatment (EVT) for acute ischemic stroke. We harmonized prospective stroke registries from Korea Taiwan enable direct comparisons of patient characteristics clinical outcomes, with a particular focus on the impact advanced age. Methods: Prospective in South (CRCS-K) (TREAT-AIS) were form unified dataset patients treated EVT. EVT outcomes included 3-month modified Rankin Scale (mRS), symptomatic...
Symptomatic intracranial hemorrhage (sICH) following endovascular thrombectomy (EVT) is a severe complication associated with adverse functional outcomes and increased mortality rates. Currently, reliable predictive model for sICH risk after EVT lacking. This study used data from patients aged ≥20 years who underwent anterior circulation stroke the nationwide Taiwan Registry of Endovascular Thrombectomy Acute Ischemic Stroke (TREAT-AIS). A including factors an was developed to differentiate...
Ordered nanodot arrays of titanium oxides were prepared from TiN/Al films on the silicon substrate by electrochemical anodization a TiN layer using nanoporous anodic aluminum oxide film as template. The microstructure was studied transmission electron microscopy and scanning microscopy, chemical composition nanodots analyzed energy loss spectroscopy. as-prepared are basically composed amorphous TiOx with hexagonal arrangement an average diameter about 60 nm. Using this approach, it is...
The relationship between endothelial dysfunction and stroke subtypes is unclear. We prospectively measured brachial flow-mediated vasodilation (FMD) in 143 patients with acute ischemic 40 controls. overall had impaired FMD, but only lacunar infarction significantly FMD vs the Impaired was an independent predictor for infarction. Ischemic associated dysfunction, which more conspicuous
Objective The objective of this article is to elucidate the outcome, prognostic predictors and timing surgical intervention for subdural hematoma (SDH) in patients with spontaneous intracranial hypotension (SIH). Methods Patients SDH were identified retrospectively from 227 consecutive SIH patients. Data collected on demographics, clinical courses, neuroimaging findings, treatment SDH, which was later divided into conservative treatment, epidural blood patches (EBP), intervention. Poor...
The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low levels may have association with intracerebral hemorrhage (ICH) severity at admission 3-month outcomes. This study used data obtained from a multi-center registry program in Taiwan. categorized acute spontaneous ICH patients, based on their baseline of total (TC) measured admission, into 3 groups <160, 160-200 >200 mg/dL TC. evaluated risk having initial severity, National Institutes...
Background The therapeutic effect of deep brain stimulation (DBS) the subthalamic nucleus (STN) for Parkinson's disease (PD) is related to modulation pathological neural activities, particularly synchronization in β band (13–35 Hz). However, whether local activity STN region can directly predict outcome remains unclear. Objective We tested hypothesis that low- (13–20 Hz) and/or high- (20–35 activities recorded from DBS efficacy. Methods Local field potentials (LFPs) were 26 patients...
Volume polarization holographic recording in phenanthrenequinone-doped poly (methyl methacrylate) photopolymer is obtained. Photoinduced birefringence a 2 mm thick sample measured by phase-modulated ellipsometry. The induced this material linearly polarized beam at 514 nm reaches 1.2×10(-5). In addition, ability for volume grating using two different configurations demonstrated and compared. experimental results show that the diffraction efficiency of hologram to ∼40% orthogonal circularly beams.
Abstract MicroRNA-34 (miR-34) is crucial for preventing chronic large-scale neurite degeneration in the aged brain of Drosophila melanogaster . Here we investigated role miR-34 two other types axon : axotomy-induced olfactory sensory neurons (OSNs) and developmentally related pruning mushroom body (MB) neurons. Ectopically overexpressed did not inhibit OSNs following axotomy, whereas ectopically differentiated MB impaired γ pruning. Intriguingly, miR-34-induced defect resulted from...
Ordered nanodot arrays of titanium oxide (TiO2) were prepared from an epitaxial Al/TiN bilayered film on a sapphire substrate by electrochemical anodization the TiN layer using nanoporous anodic aluminum (AAO) as template. The nanodots with average diameter about 60 nm can faithfully duplicate size, shape, and hexagonal pore pattern AAO nanopores. phase development isolated TiO2 is very much different thin films powders. After high temperature annealing, are polycrystalline consist mixed...
Although a lower level of non-high-density lipoprotein cholesterol (HDL-C) was reported to be inversely associated with spontaneous intracranial hemorrhage (ICH), no enough evidence has verified whether lipid profiles modify hemorrhagic transformation and functional outcomes in patients acute ischemic treated thrombolysis.This multicenter cohort study included 2373 stroke intravenous thrombolysis between December 2004 2016. Of these, 1845 were categorized into either the hyperlipidemia or...