A5101940430- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Cerebral Venous Sinus Thrombosis
- Cancer-related molecular mechanisms research
- Moyamoya disease diagnosis and treatment
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Cardiovascular Disease and Adiposity
Chonnam National University Hospital
2016-2025
Chonnam National University
2016-2025
Ulsan University Hospital
2025
Clinical Trial Investigators
2025
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Dongguk University Ilsan Hospital
2017-2023
Sungkyunkwan University
2016-2023
Asan Foundation
2023
Despite the great socioeconomic burden of stroke, there have been few reports stroke statistics in Korea. In this scenario, Epidemiologic Research Council Korean Stroke Society launched "Stroke Statistics Korea" project, aimed at writing a contemporary, comprehensive, and representative report on epidemiology This contains general prevalence behavioral vascular risk factors, characteristics, pre-hospital system care, hospital management, quality outcomes. report, we analyzed most up-to-date...
Earlier tissue plasminogen activator treatment improves ischemic stroke outcome, but aspects of the time-benefit relationship still not well delineated are: (1) degree additional benefit accrued with in first 60 minutes after onset, and (2) shape curve through 4.5 hours.We analyzed patients who had acute treated intravenous within hours onset from Get With The Guidelines-Stroke US national program. Onset-to-treatment time was as a continuous, potentially nonlinear variable categorical...
Background and Purpose— Successful reperfusion can be achieved in more than two-thirds of patients treated with mechanical thrombectomy. Therefore, it is important to understand the effect blood pressure (BP) on clinical outcomes after successful reperfusion. In this study, we investigated relationship between BP admission during first 24 hours outcomes. Methods— This was a multicenter study from 10 comprehensive stroke centers. To ensure homogeneity studied cohort, included only anterior...
Background Despite the recent acceptance of thrombectomy as standard care in patients with acute anterior circulation stroke, benefits remain uncertain for basilar artery occlusion ( BAO ). This study aimed to evaluate effectiveness and safety identify predictors outcomes a large cohort . Methods Results included 212 consecutive who underwent either stent‐retriever or contact aspiration first‐line approach between January 2011 August 2017 at 3 stroke centers. Clinical radiologic data were...
Background Untreated acute mild stroke patients have substantial 90-day disability rates and worse outcomes than those who are treated with thrombolysis. There is little information regarding which will benefit from We sought to investigate factors that associated early neurological deterioration (END) poor prognosis in stroke. Methods This was a retrospective study of consecutively registered (NIHSS ≤3) at our tertiary center between October 2008 December 2011. END defined as an increase...
Sparse data are available regarding the association between hyperglycemia and outcomes in acute ischemic stroke patients receiving mechanical thrombectomy (MT). We investigated whether affected of subjects treated with MT Solitaire Flow Restoration With Intention for Thrombectomy (SWIFT) multicenter randomized trial, overall according to reperfusion status after MT.We analyzed relationships presenting glucose level as a continuous variable (>140 mg/dL glucose) binary several interest....
<h3>BACKGROUND AND PURPOSE:</h3> Prediction of underlying intracranial atherosclerotic stenosis before endovascular therapy might be helpful for appropriate therapeutic planning in patients with acute ischemic stroke. This study aimed to compare the characteristics and treatment outcomes basilar artery occlusion relative existence or nonexistence stenosis. <h3>MATERIALS METHODS:</h3> Sixty-two underwent multimodal therapy. All stent-retriever thrombectomy as a first-line Patients additional...
Background and Purpose— Increased blood pressure (BP) variability, in addition to high BP, may contribute adverse outcome intracerebral hemorrhage. However, degree association with of BP variability (BPV) the hyperacute period, 15 minutes 5 hours after onset, have not been delineated. Methods— Among consecutive patients hemorrhage enrolled FAST-MAG trial (Field Administration Stroke Therapy-Magnesium), BPs were recorded by paramedics field during first 24 hospital course. was analyzed from 0...
The optimal treatment strategy for patients with emergent large vessel occlusion (ELVO) due to underlying severe intracranial atherosclerotic stenosis (ICAS) is unclear. purpose of this study was compare outcomes from angioplasty or without stenting and intraarterial infusion a glycoprotein IIb/IIIa inhibitor in ELVO ICAS, investigate predictors outcome after endovascular therapy such patients.
Background Preclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth rodent models inactive phase (daytime) than (nighttime) onset. We aimed to examine the association of onset time presenting severity, early neurological deterioration (END), long-term functional outcome human stroke. Methods findings In a Korean nationwide multicenter observational cohort study from May 2011 July 2020, we assessed effects on initial severity...
Background and Purpose— We compared baseline characteristics outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus posterior (PCI), including the influence of large vessel disease on outcomes. Methods— This study is an analysis a prospective multicenter registry database in South Korea. Eligibility criteria were ischemic stroke admitted within 7 days onset, lesions either or circulation, National Institutes Health Stroke Scale score ≤4 baseline....
This study aimed to investigate whether pulse pressure (PP) obtained during the acute stage of ischemic stroke can be used as a predictor for future major vascular events.Using multicenter prospective registry database, patients who were hospitalized within 48 hours onset enrolled in this study. We analyzed blood (BP) data measured first 3 days from onset. Primary and secondary outcomes time composite recurrence, myocardial infarction, all-cause death, respectively.Of 9840 patients, 4.3%...
Predictors and impact of hemorrhagic transformation (HT) after thrombectomy remain to be elucidated.To investigate the independent predictors each infarction (HI) parenchymal hematoma (PH) in patients with acute stroke due intracranial large vessel occlusion (LVO).We retrospectively reviewed data from 400 LVO who underwent thrombectomy. Logistic regression analyses were performed determine HI PH on post-treatment CT scans. Associations between HT poor outcome (modified Rankin Scalescore ≥3)...
Background and Purpose— The aim of the study was to assessed impact short-term exposure air pollution on ischemic stroke subtype, while focusing caused via cardioembolism. Methods— From a nationwide, multicenter, prospective, registry database, 13 535 patients with acute hospitalized 12 participating centers were enrolled in this study. Data hourly concentrations particulate matter <10 μm, nitrogen dioxide (NO 2 ), sulfur (SO ozone (O 3 carbon monoxide (CO) collected from 181 nationwide...
Most patients with cerebral infarction die of brain edema because the breakdown blood-brain barrier (BBB) in ischemic tissue. Caveolins (a group proteins) are key modulators vascular permeability; however, a direct role caveolin-1 (Cav-1) regulation BBB permeability during injury has yet to be identified.Cav-1 expression was measured by immunoblotting after photothrombotic ischemia. A functional Cav-1 and ischemia investigated genetic manipulation (gene disruption re-expression) protein...
Futile reperfusion (poor functional status despite successful reperfusion) was observed in up to 67% of patients enrolled recent endovascular treatment (EVT) clinical trials. We investigated the impact baseline stroke severity on both futile and therapeutic benefit EVT. Using a prospective multicenter registry, we identified consecutive ischemic with anterior circulation large artery occlusion, who were reperfused successfully by EVT (Thrombolysis Cerebral Infarction grade 2b–3). The rate...
Limited data are available about the outcomes of mechanical thrombectomy (MT) for real-world patients with stroke presenting a large core infarct.To investigate safety and effectiveness MT vessel occlusion an Alberta Stroke Program Early Computed Tomography Score (ASPECTS) 2 to 5.This retrospective cohort study used from Thrombectomy Aneurysm Registry (STAR), which combines prospectively maintained databases 28 thrombectomy-capable centers in US, Europe, Asia. The included 2345 internal...
This study aimed to investigate the effectiveness and safety of intravenous infusion tirofiban after emergent angioplasty with or without stenting in patients intracranial atherosclerotic stenosis-related large-vessel occlusion stroke.We performed a retrospective case series 98 who underwent thrombectomy followed by treat occlusion. Patients were divided into 2 groups: those received continuous for 12 hours procedure (intravenous group, n=30) did not receive postprocedural (control n=68)....
Background Some emergent large vessel occlusions (ELVOs) are refractory to reperfusion because of underlying intracranial atherosclerosis (ICAS), often requiring rescue therapy (RT) with balloon angioplasty, stenting, or both. In this study, we investigate the safety, efficacy, and long-term outcomes RT in setting mechanical thrombectomy for ICAS-related ELVO. Methods Results We queried databases 10 thrombectomy-capable centers North America Europe included STAR (Stroke Thrombectomy Aneurysm...
Recent clinical trials have shown that mechanical thrombectomy is superior to medical management for large vessel occlusion up 24 hours from onset. Our objective examine the safety and efficacy of beyond standard care window.A retrospective review was undertaken multicenter Stroke Thrombectomy Aneurysm Registry (STAR). We identified patients who underwent hours. selected a matched control group in 6-24-hour window. used functional independence at 3 months as our primary outcome measure.We...
Objectives. Inflammatory cytokines are implicated in the pathophysiology of both stroke and depression, their production is influenced by transcriptional activity particular gene polymorphisms. We hypothesised that alleles related to higher pro-inflammatory and/or lower anti-inflammatory cytokine would be associated with post-stroke depression (PSD). Methods. In 276 cases, was diagnosed using DSM-IV, classified into major PSD (N = 29), all (major plus minor) 77), control 199) groups....