A5013329437- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cerebral Venous Sinus Thrombosis
- Stroke Rehabilitation and Recovery
- Lipoproteins and Cardiovascular Health
- Vestibular and auditory disorders
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrhythmias and Treatments
- Ophthalmology and Eye Disorders
- Ocular Diseases and Behçet’s Syndrome
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trigeminal Neuralgia and Treatments
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Advanced MRI Techniques and Applications
- Retinal and Optic Conditions
Korea University Medical Center
2015-2025
Korea University
2014-2025
Cooper University Hospital
2024
University Medical Center
2024
Ewha Womans University
2023
The University of Sydney
2015-2022
Daiichi-Sankyo (South Korea)
2021
Dong-A Pharmaceutical (South Korea)
2021
National University College
2017-2021
Seoul National University Bundang Hospital
2016-2021
Despite the great socioeconomic burden of stroke, there have been few reports stroke statistics in Korea. In this scenario, Epidemiologic Research Council Korean Stroke Society launched "Stroke Statistics Korea" project, aimed at writing a contemporary, comprehensive, and representative report on epidemiology This contains general prevalence behavioral vascular risk factors, characteristics, pre-hospital system care, hospital management, quality outcomes. report, we analyzed most up-to-date...
Background and Purpose— Controversy exists over the prognostic significance of perihematomal edema (PHE) in intracerebral hemorrhage. We aimed to determine association early PHE clinical outcome among participants Intensive Blood Pressure Reduction Acute Cerebral Hemorrhage Trial (INTERACT) studies. Methods— Pooled analyses computed tomographic substudies pilot phase (INTERACT1) main (INTERACT2), both international, prospective, open, blinded end point, randomized controlled trials, patients...
Background and Purpose— The objective of this study was to investigate the potential benefits statin therapy on mortality stroke recurrence after cardioembolic stroke. Methods— In retrospective observational study, we analyzed data from 535 patients with first-ever Patients were classified into nonstatin, low-potency statin, high-potency groups. primary outcomes time recurrent Results— mean duration follow-up 22.2 months. cumulative rate 7% at end first year 10% third year. Statin...
Background There is insufficient evidence on the effect of statins, particularly high-intensity in patients with acute ischemic stroke and atrial fibrillation. We investigated impact statins outcomes these patients, including those who might be vulnerable to statin therapy without clinical atherosclerotic cardiovascular diseases. Methods Results A total 2153 fibrillation were enrolled present nationwide, multicenter, cohort study. The primary composite end point was occurrence net adverse...
Abstract We aimed to develop a novel prediction model for early neurological deterioration (END) based on an interpretable machine learning (ML) algorithm atrial fibrillation (AF)-related stroke and evaluate the accuracy feature importance of ML models. Data from multicenter prospective registries in South Korea were collected. After stepwise data preprocessing, we utilized logistic regression, support vector machine, extreme gradient boosting, light boosting (LightGBM), multilayer...
Introduction: This study assessed the therapeutic effectiveness of a single-pill combination (SPC) olmesartan/amlodipine plus rosuvastatin for blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) in patients with hypertension dyslipidemia. Methods: Adult dyslipidemia who were decided to be treated drug eligible. The primary endpoint was proportion achieved BP, LDL-C both BP treatment goals at weeks 24-48. Secondary endpoints 24-48 included changes levels from baseline;...
Importance Nelonemdaz selectively antagonizes the 2B subunit of N -methyl- d -aspartate glutamate receptor and scavenges free radical species. Objective To evaluate whether nelonemdaz enhances clinical outcomes patients with acute ischemic stroke undergoing emergent reperfusion therapy. Design, Setting, Participants This multicenter double-blind placebo-controlled randomized phase 3 trial (December 25, 2021, to June 30, 2023, in South Korea) recruited who met following criteria: National...
Introduction: Proper lipid management is vital for secondary prevention of ischemic stroke; however, not a few patients fail to reach target low-density lipoprotein cholesterol (LDL-C) levels with statin monotherapy. This study aimed provide real-world data on LDL-C achievement using rosuvastatin plus ezetimibe combination therapy (R+E) in stroke who did achieve an level <70 mg/dL statins alone. Methods: multicenter, prospective, observational enrolled adult baseline ≥70 monotherapy from...
Importance Cytochrome P450 2C19 ( CYP2C19 ) genotypes influence the antiplatelet effectiveness of clopidogrel by affecting its conversion to active metabolite. However, evidence from prospective trials regarding effects on role preventing cardiovascular events among patients with acute ischemic stroke remains limited. Objective To investigate association clinical prognosis treated clopidogrel. Design, Setting, and Participants A prospective, nonrandomized trial was conducted September 1,...
To estimate and compare the trends of all-cause cause-specific mortality rates for subjects with without diabetes in South Korea, from 2003 to 2013.Using a population-based cohort (2003 2013), we evaluated annual adults (≥30 years) diabetes. The number this analysis ranged 585,795 670,020 2013.Age- sex-adjusted decreased consistently both groups 2013 (from 14.4 9.3/1,000 persons 7.9 4.4/1,000 those diabetes). difference between also (6.61 per 1,000 4.98 2013). slope associated rate exhibited...
<h3>Objective:</h3> To investigate the role of left ventricular wall motion abnormalities (LVWMA), unrelated to high-risk cardioembolic conditions, in stroke recurrence. <h3>Methods:</h3> This study included consecutive acute ischemic patients. Transthoracic echocardiography was performed as a routine evaluation for The outcomes were time recurrent any and stroke. <h3>Results:</h3> Among 4,316 patients, 430 had LVWMA without sources. median observation periods patients at risk 24.5 24.7...
Current guideline recommends intensive blood pressure (BP) control in hypertensive patients, but the appropriate target BP level after ischemic stroke due to intracranial atherosclerotic stenosis remains uncertain.In this randomized, single-blinded trial, patients with symptomatic internal carotid or middle cerebral artery steno-occlusion (>50%) within 7-42 days index received (target SBP < 120 mmHg) modest 140 from April 2010 December 2012. The primary outcome was change lesion volume white...
Background and Purpose- Although cilostazol has shown less hemorrhagic events than aspirin, only marginal difference was observed in stroke among patients at high risk for cerebral hemorrhage. To identify who would most benefit from cilostazol, this study analyzed interactions between treatment subgroups of the PICASSO trial (Prevention Cardiovascular Events Asian Ischemic Stroke Patients With High Risk Cerebral Hemorrhage). Methods- with a previous intracerebral hemorrhage or multiple...
Depression and anxiety after stroke occur frequently have been suggested to negative influence on functional outcomes. However, the effect of emotional symptoms recurrence is uncertain. The aim this study was define recurrent cerebrovascular events in patients with ischemic stroke.This a hospital-based cohort including who participated Community Stroke Care Program that provided secondary prevention strategies during 6 months transition period discharge. We examined association between...
To investigate whether prestroke antiplatelet agent (PA) use was associated with initial stroke severity.This a retrospective, case-control study based on data from prospectively collected hospital-based registry (Korea University Stroke Registry). A total of 3,025 patients who were admitted diagnosis first-ever ischemic within 5 days symptom onset included. severity measured the NIH Scale (NIHSS). NIHSS score ≤4 at admission categorized as mild stroke. Patients PA group matched those non-PA...
In PreventIon of CArdiovascular Events in Ischaemic Stroke Patients with High Risk Cerebral HaemOrrhage (PICASSO), cilostazol versus aspirin was comparable for the end points cerebral hemorrhage and major vascular events. However, underlying hemorrhage-prone lesions could modify treatment effect.We explored whether safety efficacy would differ between (multiple microbleeds vs. prior intracerebral hemorrhage).In this post hoc analysis PICASSO, we divided patients into subgroups. The primary...
Data on the effect vascular outcomes of concomitant atherosclerotic disease (ASVD) with atrial fibrillation (AF) after stroke are limited. This study evaluated ASVD AF versus only risk events.We retrospectively analyzed a prospectively registered multicenter database involving 3213 patients AF. included extracranial atherosclerosis measured in proximal portion internal carotid artery, intracranial (all ≥50% stenosis), coronary artery disease, and peripheral was categorized into 4 strata...
To compare the efficacy and safety of antiplatelet agents for secondary prevention ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms.This study was a prospective, multicenter, randomized, parallel-group, open-label, blind genotype trial. First time non-cardiogenic patients were enrolled screened within 30 days. Participants randomized to receive either triflusal or clopidogrel prevention. The primary outcome from randomization first recurrent hemorrhagic stroke.The...