Soo Joo Lee
A5038364929- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Neurological Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Heart Rate Variability and Autonomic Control
- Clinical practice guidelines implementation
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Risk Factors
- Moyamoya disease diagnosis and treatment
- S100 Proteins and Annexins
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Peripheral Nerve Disorders
Eulji University Hospital
2016-2025
Eulji University
2016-2025
Inje University Ilsan Paik Hospital
2015-2024
Vanderbilt University Medical Center
2024
Institute for Clinical Evaluative Sciences
2024
University of California, Los Angeles
2010-2024
Massachusetts General Hospital
2024
Cedars-Sinai Smidt Heart Institute
2024
Cedars-Sinai Medical Center
2024
Dongguk University
2012-2024
Despite the great socioeconomic burden of stroke, there have been few reports stroke statistics in Korea. In this scenario, Epidemiologic Research Council Korean Stroke Society launched "Stroke Statistics Korea" project, aimed at writing a contemporary, comprehensive, and representative report on epidemiology This contains general prevalence behavioral vascular risk factors, characteristics, pre-hospital system care, hospital management, quality outcomes. report, we analyzed most up-to-date...
In order to improve inter-rater reliability and minimize diagnosis of undetermined etiology for stroke subtype classification, using a registry, we developed implemented magnetic resonance imaging (MRI)-based algorithm acute ischemic classification (MAGIC).We enrolled patients who experienced an stroke, were hospitalized in the 14 participating centers within 7 days onset, had relevant lesions on MR-diffusion weighted (DWI). MAGIC was designed reflect recent advances thrombolytic therapy....
Leukoaraiosis or white matter hyperintensities are frequently observed on magnetic resonance imaging of stroke patients. We investigated how hyperintensity volumes affect outcomes, generally and by subtype. In total, 5035 acute ischaemic patients were enrolled. Strokes classified as large artery atherosclerosis, small vessel occlusion, cardioembolism. White stratified into quintiles. Mean age (± standard deviation) was 66.3 ± 12.8, 59.6% male. Median (interquartile range) modified Rankin...
There are limited data on the utilization of diagnostics and variation treatments at national level in acute stroke care. Clinical Research Center for Stroke – 5th division registry aimed to describe statistics quality care Korea implement indicators. was established April 2008 covers pretreatment demographics, medical severity measures, diagnostic evaluation, hyperacute revascularization, in-hospital management, discharge disposition, indicators, long-term functional outcomes. Consecutive...
<h3>Objective</h3> To improve epidemiologic knowledge of neurologic deterioration (ND) in patients with acute ischemic stroke (AIS). <h3>Methods</h3> In this prospective observational study, we captured ND prospectively 29,446 AIS admitted to 15 hospitals Korea within 7 days onset. was defined as an increase NIH Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor consciousness), any new symptoms. Change incidence rate after onset, causes, factors associated ND, modified Rankin (mRS) at 3...
Background Preclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth rodent models inactive phase (daytime) than (nighttime) onset. We aimed to examine the association of onset time presenting severity, early neurological deterioration (END), long-term functional outcome human stroke. Methods findings In a Korean nationwide multicenter observational cohort study from May 2011 July 2020, we assessed effects on initial severity...
Background and Purpose— We compared baseline characteristics outcomes at 3 months between patients with minor anterior circulation infarction (ACI) versus posterior (PCI), including the influence of large vessel disease on outcomes. Methods— This study is an analysis a prospective multicenter registry database in South Korea. Eligibility criteria were ischemic stroke admitted within 7 days onset, lesions either or circulation, National Institutes Health Stroke Scale score ≤4 baseline....
This study aimed to investigate whether pulse pressure (PP) obtained during the acute stage of ischemic stroke can be used as a predictor for future major vascular events.Using multicenter prospective registry database, patients who were hospitalized within 48 hours onset enrolled in this study. We analyzed blood (BP) data measured first 3 days from onset. Primary and secondary outcomes time composite recurrence, myocardial infarction, all-cause death, respectively.Of 9840 patients, 4.3%...
Background and Purpose— The aim of the study was to assessed impact short-term exposure air pollution on ischemic stroke subtype, while focusing caused via cardioembolism. Methods— From a nationwide, multicenter, prospective, registry database, 13 535 patients with acute hospitalized 12 participating centers were enrolled in this study. Data hourly concentrations particulate matter <10 μm, nitrogen dioxide (NO 2 ), sulfur (SO ozone (O 3 carbon monoxide (CO) collected from 181 nationwide...
Cerebral vascular territories are of key clinical importance in patients with stroke, but available maps highly variable and based on prior studies small sample sizes.To update improve the state knowledge supratentorial supply to brain by using natural experiment large artery infarcts map out anatomy anterior, middle, posterior cerebral (ACA, MCA, PCA) territories.In this cross-sectional study, digital were generated diffusion-weighted magnetic resonance imaging (MRI) 1160 acute (<1-week)...
Futile reperfusion (poor functional status despite successful reperfusion) was observed in up to 67% of patients enrolled recent endovascular treatment (EVT) clinical trials. We investigated the impact baseline stroke severity on both futile and therapeutic benefit EVT. Using a prospective multicenter registry, we identified consecutive ischemic with anterior circulation large artery occlusion, who were reperfused successfully by EVT (Thrombolysis Cerebral Infarction grade 2b–3). The rate...
<h3>Background and Objectives</h3> Female patients tend to have greater disability worse long-term outcomes after stroke than male patients. To date, the biological basis of sex difference in ischemic remains unclear. We aimed 1) assess differences clinical manifestation acute 2) investigate whether disparity is due different infarct locations or impacts same location. <h3>Methods</h3> This MRI-based multicenter study included 6,464 consecutive with (<7-days) from 11-centers South-Korea...
<i>Background:</i> Aspirin is a proven antiplatelet agent in acute ischemic stroke, and there are no current guidelines for other treatments. We aimed to compare the efficacy safety of cilostazol with aspirin stroke. <i>Methods:</i> Patients measurable neurological deficits (NIHSS score ≤15) within 48 h onset were randomly assigned (200 mg/day) or (300 90 days. The primary endpoint was modified Rankin Scale (mRS) 0–2 at Cardiovascular events, bleeding complications,...
We aimed to generate rigorous graphical and statistical reference data based on volumetric measurements for assessing the relative severity of white matter hyperintensities (WMHs) in patients with stroke.We prospectively mapped WMHs from 2699 first-ever ischemic stroke (mean age=66.8±13.0 years) enrolled consecutively 11 nationwide centers, patient (fluid-attenuated-inversion-recovery) MRIs onto a standard brain template set. Using multivariable analyses, we assessed impact major...
In patients with acute ischemic stroke caused by large artery atherosclerosis, clopidogrel plus aspirin versus alone might be more effective to prevent recurrent cerebral ischemia. However, there is no clear evidence.In this multicenter, double-blind, placebo-controlled trial, we randomized 358 of presumed atherosclerosis origin within 48 hours onset (75 mg/d without loading dose) (300-mg followed 100 mg/d) or for 30 days. The primary outcome was new symptomatic asymptomatic lesion on...
The low-dose (0.6 mg/kg) alteplase strategy to treat acute ischemic stroke patients became widespread in East Asian countries, without rigorous testing against standard-dose (0.9 treatment. Our aim was investigate the comparative effectiveness and safety of versus intravenous strategy.A total 1526 who qualified for treated within 4.5 hours were identified from a prospective, multicenter, nationwide registry database. Primary outcomes modified Rankin scale score 0 1 at 3 months after...
Estimating age- and sex-specific population attributable risks (PARs) of major risk factors for stroke may be a useful strategy to identify targeting preventive strategies. For this case-control matched study, consecutive patients aged 18-90 years admitted nine nationwide hospitals with acute ischemic between December 2008 June 2010, were enrolled as cases. Controls, individually by age sex, chosen from the 4th Korean National Health & Nutrition Examination Survey (2008-2010). Based on odds...
<h3>Objective</h3> To define the role and risks associated with white matter hyperintensity (WMH) load in a stroke population respect to recurrent mortality after ischemic stroke. <h3>Methods</h3> A total of 7,101 patients at network university hospitals presenting strokes were followed up for 1 year. Multivariable Cox proportional hazards model competing risk analysis used examine independent association between quartiles WMH recurrence <h3>Results</h3> Overall year was 6.7%/y, divided...
Background and Purpose- There is a paucity of information about the role resting heart rate in prediction outcome events patients with ischemic stroke atrial fibrillation. We aimed to investigate relationships between level variability acute period recurrence mortality after Methods- Acute who had fibrillation were hospitalized within 48 hours onset identified from multicenter prospective registry database. The was divided into early (within 24 hospitalization) late (72 7 days onset) stages,...
We evaluated the efficacy of endovascular thrombectomy (EVT) on functional outcome patients with acute basilar artery occlusion and low posterior circulation stroke prognosis early computed tomography score (PC-ASPECTS).
To evaluate the frequency of intracranial atherosclerosis among patients with steno-occlusive extracranial carotid artery disease and to determine if there are factors related combined atherosclerosis.Cross-sectional study.A tertiary referral hospital. Patients We studied 142 consecutive who had atherosclerotic lesions (defined as > or =30% narrowing luminal diameter occlusion) an confirmed by conventional angiography. excluded potential cardiogenic sources embolism. Potential vascular risk...