A5060704735- Acute Ischemic Stroke Management
- Disaster Response and Management
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Emergency and Acute Care Studies
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Disaster Management and Resilience
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Airway Management and Intubation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Climate Change and Health Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Restraint-Related Deaths
- Trauma Management and Diagnosis
- Healthcare Policy and Management
- Mechanical Circulatory Support Devices
- Neuroscience of respiration and sleep
- Global Public Health Policies and Epidemiology
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Health and Conflict Studies
- Artificial Intelligence in Healthcare and Education
Orange County Healthcare Agency
2007-2025
University of California, Los Angeles
2014-2025
Harbor–UCLA Medical Center
2000-2022
Greater Los Angeles Agency on Deafness
2017-2022
SUNY Downstate Health Sciences University
2022
State University of New York
2022
NYU Langone Health
2022
Maimonides Medical Center
2022
Bellevue Hospital Center
2022
Kings County Hospital Center
2022
Context Endotracheal intubation (ETI) is widely used for airway management of children in the out-of-hospital setting, despite a lack controlled trials demonstrating positive effect on survival or neurological outcome.Objective To compare and outcomes pediatric patients treated with bag-valve-mask ventilation (BVM) those BVM followed by ETI.Design Controlled clinical trial, which were assigned to interventions calendar day from March 15, 1994, through January 1, 1997.Setting Two large,...
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Magnesium sulfate is neuroprotective in preclinical models of stroke and has shown signals potential efficacy with an acceptable safety profile when delivered early after onset humans. Delayed initiation agents hindered earlier phase 3 trials agents.We randomly assigned patients suspected to receive either intravenous magnesium or placebo, beginning within 2 hours symptom onset. A loading dose was initiated by paramedics before the patient arrived at hospital, a 24-hour maintenance infusion...
Prehospital intubation and airway control is routinely performed by paramedics in critically injured patients. Despite the advantages provided this procedure, numerous potential risks exist when field. We reviewed outcome of patients with severe head injury, to determine whether prehospital associated an improved outcome.A retrospective review registry data admitted urban trauma center injury (field Glasgow Coma Scale score < or =8 Abbreviated Injury > =3) was performed. Patients were...
Background and Purpose— Prehospital scales have been developed to identify patients with acute cerebral ischemia (ACI) because of large vessel occlusion (LVO) for direct routing Comprehensive Stroke Centers (CSCs), but few validated in the prehospital setting, their impact on intracranial hemorrhage has not delineated. The purpose this study was validate Los Angeles Motor Scale (LAMS) LVO CSC-appropriate (LVO ACI patients) recognition compare LAMS other scales. Methods— performance LAMS,...
Background and Purpose— Increased blood pressure (BP) variability, in addition to high BP, may contribute adverse outcome intracerebral hemorrhage. However, degree association with of BP variability (BPV) the hyperacute period, 15 minutes 5 hours after onset, have not been delineated. Methods— Among consecutive patients hemorrhage enrolled FAST-MAG trial (Field Administration Stroke Therapy-Magnesium), BPs were recorded by paramedics field during first 24 hospital course. was analyzed from 0...
In 2003, the Task Force on Quality Control of Disaster Management (WADEM) published guidelines for evaluation and research health disaster management recommended development a uniform data reporting tool. Standardized complete related to medical response activities will facilitate interpretation results, comparisons between systems quality improvement in victims.Over two-year period, group 16 experts fields research, education, ethics operational aspects from 8 countries carried out...
Rationale In acute stroke, the volume of salvageable brain tissue is maximal at onset and declines rapidly with time. Prehospital start clinical trial interventions would enable delivery neuroprotective agents, such as magnesium sulfate, to stroke patients in hyperacute period when they are potentially most effective. Aims A broad aim FAST-MAG study develop validate techniques perform pivotal trials therapies for prehospital setting. tandem an accompanying general design article, this...
<h3>Importance</h3> Studies of neurological deterioration in stroke have focused on the subacute period, but treatment is increasingly migrating to prehospital setting, where course has not been well delineated. <h3>Objective</h3> To describe frequency, predictors, and outcomes among patients ultra-early period following ischemic or intracranial hemorrhage. <h3>Design, Settings, Participants</h3> Exploratory analysis prehospital, randomized Field Administration Stroke Therapy-Magnesium...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the 'Save PDF' action button.
Rationale Prehospital initiation by paramedics may enable delivery of neuroprotective therapies to stroke patients in the hyperacute period when they are most effective preclinical studies. Magnesium is experimental models and has been shown be safe with signals potential efficacy started early after onset human cerebral ischemia. Aims (a) To demonstrate that paramedic agent magnesium sulfate field an efficacious treatment for acute stroke; (b) enrollment a practical feasible strategy phase...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.
This study was designed to determine whether out-of-hospital clinical signs could be associated with functional survival for pulseless, unconscious victims of penetrating trauma.A retrospective review medical data and outcome urban trauma during 1993-1994. For comparison the group, blunt same period are reported. Logistic regression, odds ratios, positive predictive values, sensitivity, specificity were used possible association field survival.A total 879 met criteria study. Four 497 injury...
Objective In the prehospital setting, countershock terminates ventricular fibrillation (VF) in about 80% of cases. However, is most commonly followed by asystole or pulseless electrical activity (PEA). The consequences such a outcome have not been well studied. purpose this investigation was to compare VF victims shocked into PEA with that patients whose first documented rhythm (primary PEA). Design Observational, retrospective study conducted over 5 yrs (1995–1999). Setting A municipal...
Background and Purpose— The Los Angeles Motor Scale (LAMS) is a 3-item, 0- to 10-point motor stroke-deficit scale developed for prehospital use. We assessed the convergent, divergent, predictive validity of LAMS when performed by paramedics in field at multiple sites large diverse geographic region. Methods— analyzed early assessment outcome data prospectively gathered FAST-MAG trial (Field Administration Stroke Therapy–Magnesium phase 3) among patients with acute cerebrovascular disease...