A5039917526- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Cognitive Abilities and Testing
- Personality Traits and Psychology
- Personality Disorders and Psychopathology
- Genetic Mapping and Diversity in Plants and Animals
- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Autism Spectrum Disorder Research
- Alcohol Consumption and Health Effects
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Distributed and Parallel Computing Systems
- Health Systems, Economic Evaluations, Quality of Life
- Evolutionary Psychology and Human Behavior
- Health, Environment, Cognitive Aging
- Attachment and Relationship Dynamics
- Genetic and phenotypic traits in livestock
- Neurotransmitter Receptor Influence on Behavior
Johnson University
2022-2025
Rutgers, The State University of New Jersey
2022-2025
Rutgers Sexual and Reproductive Health and Rights
2022-2025
Emory University
2016-2024
Virginia Commonwealth University
2021-2022
University of Missouri
2019
Several recent studies of the hierarchical phenotypic structure psychopathology have identified a General factor in addition to more expected specific Externalizing and Internalizing dimensions both youth adult samples some found relevant unique external correlates this factor. We used data from 1,568 twin pairs (599 MZ & 969 DZ) age 9 17 test hypotheses for underlying validity higher-order factors. Psychopathology symptoms were assessed via structured interviews caretakers youth. conducted...
We advanced several “riskier tests” of the validity bifactor models psychopathology, which included that general and specific psychopathology factors should be reliable well represented by their respective indicators including a factor improve on correlated model’s external validity. compared using data from community sample youth ( N = 2,498) whose parents provided ratings theoretically relevant criteria (i.e., personality, aggression, antisociality). Bifactor tended to yield either or were...
Consistent evidence has documented the cross-sectional and longitudinal associations of externalizing psychopathology with personality behavioral traits, suggesting presence a broad, underlying liability to externalizing. In one first studies its kind, we use large, representative sample youth (N = 2,245 twins their siblings) evaluate an spectrum model, which includes psychopathology, personality, traits spans normal pathological variation. We examine for inclusion 15 candidate from domains...
Abstract There is evidence that models of psychopathology specifying a general factor and specific second‐order factors fit better than competing structural models. Nonetheless, additional tests are needed to examine the generality boundaries model. In selected second wave cohort study, first‐order dimensions symptoms in 499 23‐ 31‐year‐old twins were analyzed. Using confirmatory analysis, bifactor model internalizing externalizing Factor loadings this sex invariant despite greater variances...
Genome‐wide association studies (GWAS) have revealed hundreds of genetic loci associated with the vulnerability to major psychiatric disorders, and post‐GWAS analyses shown substantial correlations among these disorders. This evidence supports existence a higher‐order structure psychopathology at both phenotypic levels. Despite recent efforts by collaborative consortia such as Hierarchical Taxonomy Psychopathology (HiTOP), this remains unclear. In study, we tested multiple alternative...
The past several decades have witnessed a proliferation of research on the dark triad (DT), set traits comprising Machiavellianism, narcissism, and psychopathy. bulk DT has been marked by core assumptions, most notably that each construct is monolithic entity clearly separable from its counterpart constructs. To examine tenability these we pooled data 2 samples North American community members (ns = 312 351) to explore (a) external validity profile similarities indicators (b) factor...
Historically, researchers have proposed higher-order factors to explicate the structure of psychopathology, including Externalizing, Internalizing, Fear, Distress, Thought Disorder, and a general factor. Despite extensive research in this domain, underlying psychopathology remains unresolved. Here, we examine several issues adjudicating among structural models psychopathology. Using simulations analyses extant literature, contrast model-based reliability alternative highlight shortcomings...
Abstract Substance use disorders (SUDs) are phenotypically and genetically correlated with each other psychological traits characterized by behavioural under‐control, termed externalizing phenotypes. In this study, we used genomic structural equation modelling to explore the shared genetic architecture among six phenotypes four SUDs in two previous multivariate genome‐wide association studies of an addiction risk factor, respectively. We first evaluated five confirmatory factor analytic...
Abstract Behaviors and disorders related to self-regulation, such as substance use, antisocial conduct, ADHD, are collectively referred externalizing have a shared genetic liability. We applied multivariate approach that leverages correlations among traits for genome-wide association analyses. By pooling data from ~1.5 million people, our is statistically more powerful than single-trait analyses identifies 500 loci. The identified loci were enriched genes expressed in the brain nervous...
The purpose of this study was to examine possible pathways by which genetic risk associated with externalizing is transmitted in families. We used molecular data disentangle the and environmental contributing adolescent behavior a sample 1,111 adolescents (50% female; 719 European 392 African ancestry) their parents from Collaborative Study on Genetics Alcoholism. found evidence for nurture such that parental polygenic scores were behavior, over above effect adolescents' own scores....
Proprietary genetic datasets are valuable for boosting the statistical power of genome-wide association studies (GWASs), but their use can restrict investigators from publicly sharing resulting summary statistics. Although researchers resort to down-sampled versions that exclude restricted data, down-sampling reduces and might change etiology phenotype being studied. These problems further complicated when using multivariate GWAS methods, such as genomic structural equation modeling (Genomic...
Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from five large datasets characterize behavioral manifestations of a liability toward externalizing ages 6 months- 26 years. We used polygenic scores (PGS) derived multivariate GWAS Externalizing that identified hundreds significantly associated variants (EXTPGS) estimate associations with relevant phenotypes...
Abstract Genome-wide association studies (GWAS) identify genetic variants associated with a trait, regardless of how those are the outcome. Characterizing whether for psychiatric outcomes operate via specific versus general pathways provides more informative measures risk. In current analysis, we used multivariate GWAS to tease apart problematic alcohol use (ALCP-total) through either shared risk externalizing (EXT) or use-specific (ALCP-specific). SNPs ALCP-specific were primarily related...
AbstractObjective: Understanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from five large datasets characterize behavioral manifestations of a liability toward undercontrol ages 6 months- 26 years. Method: We used polygenic scores (PGS) derived multivariate GWAS Externalizing that identified variants associated with behaviors related (EXTPGS) estimate associations...
Proprietary genetic datasets are valuable for boosting the statistical power of genome-wide association studies (GWASs), but their use can restrict investigators from publicly sharing resulting summary statistics. Although researchers resort to down-sampled versions that exclude restricted data, down-sampling reduces and might change etiology phenotype being studied. These problems further complicated when using multivariate GWAS methods, such as genomic structural equation modeling (Genomic...
Interest has increased in the recent literature on characterizing psychopathology dimensionally hierarchical models. One dimension of that received considerable attention is externalizing. Although extensively studied and well-characterized late adolescents adults, delineation externalizing spectrum youth lagged behind. As a complement to structural analyses externalizing, this study, we use quantitative genetic twin data adjudicate among alternative models differ granularity. Specifically,...
Genome-wide association studies (GWAS) have revealed hundreds of genetic loci associated with the vulnerability to major psychiatric disorders, and post-GWAS analyses shown substantial correlations among these disorders. This evidence supports existence a higher-order structure psychopathology at both phenotypic levels. Despite recent efforts by collaborative consortia such as Hierarchical Taxonomy Psychopathology (HiTOP), this remains unclear. In study, we tested multiple alternative...
Historically, researchers have proposed higher-order factors to explicate the structure of psychopathology, including Externalizing, Internalizing, Fear, Distress, Thought Disorder, and a general factor. Despite extensive research in this domain, underlying psychopathology remains unresolved. Herein, we examine several issues adjudicating among structural models psychopathology. Using simulations analyses extant literature, contrast model-based reliability alternative highlight shortcomings...
The study of psychopathic traits in youth is its nascent stages and the nature structure these still poorly understood. In one most comprehensive analyses to date construct validity widely used Antisocial Processing Screening Device (APSD), we two independent samples youth, community (N = 2203) clinic-referred 534), ages 4 19 (51% female), investigate external correlates Callous-unemotionality (CU), Narcissism, Impulsivity dimensions psychopathy. We parent reports externalizing internalizing...
Abstract Importance Characterizing whether genetic variants for psychiatric outcomes operate via specific versus general pathways provides more informative measures of risk, and, potentially, allows us to design targeted prevention and interventions. Objective Employ multivariate methods tease apart associated with problematic alcohol use through either or compare results standard univariate analysis use. Design We compared from a genome wide association study (GWAS) those previous GWAS...
We advanced several “riskier tests” of the validity bifactor models psychopathology, which included that general and specific factors should be reliable well-represented by their indicators, including a factor improve correlated model’s external validity. compared using data from community sample youth (N=2498) whose parents provided ratings on psychopathology criteria (i.e., temperament, aggression, antisociality). Bifactor tended to yield either or were unstable difficult interpret. The...