A5041481984- Genetic Associations and Epidemiology
- Psychological Well-being and Life Satisfaction
- Health disparities and outcomes
- Cognitive Abilities and Testing
- Birth, Development, and Health
- Mental Health Research Topics
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Optimism, Hope, and Well-being
- Child and Adolescent Psychosocial and Emotional Development
- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- Resilience and Mental Health
- Identity, Memory, and Therapy
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Behavioral Health and Interventions
- Adolescent and Pediatric Healthcare
- Smoking Behavior and Cessation
- Intergenerational Family Dynamics and Caregiving
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Family Support in Illness
- Ethics in Clinical Research
Amsterdam University of Applied Sciences
2022-2023
Vrije Universiteit Amsterdam
2015-2021
The University of Queensland
2020-2021
Amsterdam University Medical Centers
2019
Amsterdam Neuroscience
2014-2019
Public Health Service of Amsterdam
2017
Amsterdam Public Health
2015-2016
SURFsara (Netherlands)
2016
Legal Pathways
2016
Washington Center
2016
Whether well-being and depressive symptoms can be considered as two sides of the same coin is widely debated. The aim this study was to gain insight into etiology association between across lifespan. In a large twin-design, including data from 43,427 twins age 7 99, we estimated throughout lifespan assessed genetic environmental contributions observed overlap. For both (range 31-47%) 49-61%), factors explained substantial part phenotypic variance Phenotypic correlations ages ranged -0.34 in...
To estimate associations between smoking initiation, persistence and heaviness caffeine consumption in two population-based samples from the Netherlands United Kingdom.Observational study employing data on self-reported behaviour consumption.Adults general population Kingdom.Participants Twin Register [NTR: n = 21 939, mean age 40.8, standard deviation (SD) 16.9, 62.6% female] Avon Longitudinal Study of Parents Children (ALSPAC: 9086, 33.2, SD 4.7, 100% female).Smoking initiation (ever...
Humans are social animals that experience intense suffering when they perceive a lack of connection. Modern societies experiencing an epidemic loneliness. Although the loneliness is universally human, some people report greater than others. Loneliness more strongly associated with mortality obesity, emphasizing need to understand nature relationship between and health. it intuitive circumstantial factors such as marital status age influence loneliness, there also compelling evidence genetic...
The interrelations among well-being, neuroticism, and depression can be captured in a so-called well-being spectrum (3-phenotype spectrum, 3-WBS). Several other human traits are likely linked to the 3-WBS. In present study, we investigate how 3-WBS expanded. First, constructed polygenic risk scores for used this score predict series of that have been associated with literature. We included information on loneliness, big five personality traits, self-rated health, flourishing. predicted all...
Whether hedonism or eudaimonia are two distinguishable forms of well-being is a topic ongoing debate. To shed light on the relation between two, large-scale available molecular genetic data were leveraged to gain more insight into architecture overlap hedonic and eudaimonic well-being. Hence, we conducted first genome-wide association studies (GWAS) (N = ~108 K) linked it GWAS ~222 K). We identified significant independent loci for six Joint analyses revealed moderate phenotypic correlation...
Loneliness is a heritable trait that accompanies multiple disorders. The association between loneliness and mental health indices may partly be due to inherited biological factors. We constructed polygenic scores for 27 traits related behavior, cognition tested their prediction self-reported in population-based sample of 8798 Dutch individuals. Polygenic major depressive disorder (MDD), schizophrenia bipolar were significantly associated with loneliness. Of the Big Five personality...
Aggressive behavior is highly heritable, while environmental influences, particularly early in life, are also important. Epigenetic mechanisms, such as DNA methylation, regulate gene expression throughout development and adulthood, may mediate genetic effects on complex traits. We performed an epigenome-wide association study (EWAS) to identify regions the genome where methylation level associated with aggressive behavior. Subjects took part longitudinal survey studies from Netherlands Twin...
Resilience and well-being are strongly related. People with higher levels of more resilient after stressful life events or trauma vice versa. Less is known about the underlying sources overlap causality between constructs. In a sample 11.304 twins 2.572 siblings from Netherlands Twin Register, we investigated possible direction causation resilience (i.e. absence psychiatric symptoms despite negative events) satisfaction life) using polygenic score (PGS) prediction, twin-sibling modelling,...
A remarkable pathological difference between grey matter lesions (GML) and white (WML) in Multiple Sclerosis (MS) patients is the paucity of infiltrating leukocytes GML. To better understand these differences, we hypothesize that chemokine monocyte chemotactic protein-1 (MCP-1 or CCL2), importance for leukocyte migration, its receptor CCR2 are more abundantly expressed WML than GML MS patients. this end, analyzed CCL2 expression hippocampus, comprising GML,of post-mortem patients, control...
Tic disorders are moderately heritable common psychiatric that can be highly troubling, both in childhood and adulthood. In this study, we report results obtained the first epigenome-wide association study (EWAS) of tic disorders. The subjects participants surveys at Netherlands Twin Register (NTR) NTR biobank project. were measured with a self-report version Yale Global Severity Scale Abbreviated (YGTSS-ABBR), included 8th wave data collection (2008). DNA methylation consisted 411,169...
Abstract Smoking and caffeine consumption show a strong positive correlation, but the mechanism underlying this association is unclear. Explanations include shared genetic/environmental factors or causal effects. This study employed three methods to investigate between smoking caffeine. First, bivariate genetic models were applied data of 10 368 twins from Netherlands Twin Register in order estimate environmental correlations use. Second, summary statistics meta‐analyses genome‐wide studies...
Abstract The adult self report (ASR) is a well-validated instrument with multiple scales relating to psychopathology. Recently, an 18-item version has been introduced, the brief problem monitor (BPM) measure Internalizing behavior (INT), Externalizing (EXT), and attention problems (ATT). present study compared BPM ASR investigated how well can serve as supplement or alternative for specific clinical scientific purposes. In large sample of twins (N = 9.835) from Netherlands Twin Register...
To gain more insight into the biological factors that mediate vulnerability to display externalizing behaviors, we leveraged genome-wide association study summary statistics on 13 phenotypes.After data classification based genetic resemblance, performed multivariate meta-analyses and conducted extensive bioinformatic analyses, including correlation assessment with other traits, Mendelian randomization, gene set expression analyses.The could be categorized disruptive behavior (DB) risk-taking...
Approximately half of the variation in wellbeing measures overlaps with personality traits. Studies non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether polygenic scores for NEO Five-Factor Inventory (NEO-FFI) domains item response theory (IRT) derived extraversion neuroticism predict variance measures. Polygenic were based on published genome-wide association (GWA) results over 17,000 individuals NEO-FFI 63,000 IRT The used...
To study the underpinnings of individual differences in subjective well-being (SWB), we tested for associations SWB with subcortical brain volumes a dataset 724 twins and siblings. For significant SWB-brain probed causal pathways using Mendelian Randomization (MR) estimated genetic environmental contributions from twin modeling. Another independent measure correlation was obtained linkage disequilibrium (LD) score regression on published genome-wide association summary statistics. Our...