A5080659877- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Research and Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Protein Tyrosine Phosphatases
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Treatment and Pharmacology
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Multiple and Secondary Primary Cancers
- Economic and Financial Impacts of Cancer
- Sarcoma Diagnosis and Treatment
- Liver physiology and pathology
Watford General Hospital
2023
Johns Hopkins University
2021-2022
University of New Mexico
2012-2021
New Mexico Cancer Center
2010-2021
Sidney Kimmel Comprehensive Cancer Center
2021
Johns Hopkins Medicine
2021
Rama University
2021
Sidney Kimmel Cancer Center
2020
Sibley Memorial Hospital
2020
UNM Comprehensive Cancer Center
2010-2019
To extend earlier observations of germline E-cadherin mutations in kindreds with an inherited susceptibility to diffuse gastric cancer, we searched for five further families affected predominantly by cancer and one family a history early-onset breast cancer. Heterozygous inactivating were found the gene each these families. No mutation hotspots identified. These results demonstrate that is common cause hereditary suggest role incidence Hum Mutat 14:249–255, 1999. © 1999 Wiley-Liss, Inc.
In Brief Objective: To assess whether TNODS is an independent prognostic factor after adjusting for the lymph node ratio (LNR). Summary Background Data: The medical literature has suggested that associated with better survival in stage II and III colon cancer. Thus was endorsed as a quality measure patient care by American College of Surgeons, National Quality Forum. There is, however, little biologic rationale to support this linkage. Methods: A total 24,477 cancer patients were identified...
Abnormal accumulation and activation of receptor tyrosine kinase Ron (recepteur d'origine nantais) has been demonstrated in a variety primary human cancers. We show that RNA interference-mediated knockdown highly tumorigenic colon cancer cell line led to reduced proliferation as compared with the control cells. Decreased expression sensitized HCT116 cells growth factor deprivation stress-induced apoptosis reflected by increased DNA fragmentation caspase 3 activation. In addition, motility...
Background: Cancer survivors increasingly report financial hardship as a consequence of the high cost cancer care, yet experience rural remains largely unstudied. The purpose this study was to investigate potential disparities in likelihood and nonadherence surveillance colonoscopy.Methods: Individuals diagnosed with localized or regional colorectal between 2004 2012 were ascertained by population-based New Mexico Tumor Registry. Participants completed mailed questionnaire telephone survey...
Palliative medicine was recognized as a unique medical specialty in 2006. Since that time, the number of hospital-based palliative care services has increased dramatically. It is unclear how consultation (PCCS) are utilized by surgical services. The purpose this study to examine utilization PCCS compared at University New Mexico.A database consultations performed Mexico Hospital between 2009 and 2013 queried identify requested vs. Demographic, clinical, outcome variables were compared.A...
The National Comprehensive Cancer Network (NCCN) Outcomes Database was created to assess concordance evidence- and consensus-based guidelines measure adherence quality measures on an ongoing basis. Colorectal began in 2005 as a collaboration among 8 NCCN centers.Newly diagnosed colon rectal cancer patients presenting 1 of centers between September 1, 2005, May 21, 2008, were eligible for analysis with treatment colorectal set metrics jointly developed by ASCO 2007. Adherence rates determined...
To determine rate and predictors of sphincter-preserving surgery (SPS) for rectal cancer patients treated at specialty institutions.SPS has been considered a surrogate surgical quality, sphincter preservation is tremendously important to patients. Evidence association between case volume SPS prompted recommendations that all undergo institutions. However, rates SPS, the factors associated with ability perform have not well-characterized.A prospective registry colorectal 7 National...
Metastasis causes most deaths from cancer yet mechanistic understanding and therapeutic options remain limited. Overexpression of the phosphatase PRL-3 (phosphatase regenerating liver) is associated with metastasis colon cancer. Here, we show that a direct target signaling by TGFβ, which broadly implicated in progression metastasis. We found suppression expression TGFβ was mediated Smad-dependent inhibition transcription at level promoter activity. activation stimulated PI3K/AKT caused...
BackgroundColorectal cancer is a leading cause of cancer-related mortality, has very broad mutational spectrum, and there no clinically available biomarker that can predict which patients with stage II or III colorectal will develop metastatic disease.Patients MethodsWe used targeted next-generation sequencing approach to analyze the spectra in colon patient samples.ResultsAmidst range acquired mutations variants, we found evidence tumor heterogeneity distinguished tumors different groups....
Article Tools DIAGNOSIS IN ONCOLOGY OPTIONS & TOOLS Export Citation Track Add To Favorites Rights Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.02.092 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 14512403 Diagnostic Challenges in Patients With Tumors CASE 1. GOSSYPIBOMA (FOREIGN BODY) MANIFESTING 30 YEARS AFTER LAPAROTOMY Ashwani RajputxAshwani RajputSearch for by this author , Peter A. LoudxPeter...
An estimated 5-10% of all pancreatic adenocarcinomas have a hereditary association. The objective the current study was to characterize clinical and pathologic features familial carcinoma determine potential differences in demographics, risk factors, outcomes between sporadic populations.A retrospective review performed identify patients diagnosed with who had an associated disposition. Demographic analyses assessment treatment were for subgroup, results compared observations made...
Abstract Mutations in the PIK3CA gene are common human cancers, including colon cancer. We compared two pairs of cancer cells (HCT116 and DLD1) bearing only wild-type (WT) or mutant (MUT) allele for their survival capacity under stress conditions vitro as well metastatic properties an vivo orthotopic model. When subjected to growth factor deprivation (GFDS), MUT displayed resistance GFDS-induced apoptosis relative WT cells. Phosphatidylinositol 3-kinase (PI3K) its downstream effector AKT...
Background Understanding drivers for metastasis in human cancer is important potential development of therapies to treat metastases. The role loss TGFβ tumor suppressor activities the metastatic process essentially unknown. Methodology/Principal Findings Utilizing vitro and vivo techniques, we have shown that signaling necessary allow last step - colonization site. This work demonstrates first time receptor reconstitution leads decreased colonization. Moreover, identified a novel TGFβ/PKA...
BackgroundNeoadjuvant chemoradiotherapy (nCRT) is the standard of care for locally advanced adenocarcinoma rectum, but it currently unknown which patients have disease that will respond. This study tested correlation between response to nCRT and intratumoral heterogeneity using next-generation sequencing assays.Patients MethodsDNA was extracted from formalin-fixed, paraffin-embedded biopsy samples a cohort with rectal (T3/4 or N1/2 disease) who received nCRT. High read-depth > 400...