A5103203323- Autophagy in Disease and Therapy
- Pain Mechanisms and Treatments
- Prenatal Screening and Diagnostics
- Calcium signaling and nucleotide metabolism
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Ginseng Biological Effects and Applications
- Viral-associated cancers and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Biochemical effects in animals
- Cancer Treatment and Pharmacology
- Drug Transport and Resistance Mechanisms
- Amino Acid Enzymes and Metabolism
- Lymphoma Diagnosis and Treatment
- NF-κB Signaling Pathways
- Microbial Metabolic Engineering and Bioproduction
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Biological Research and Disease Studies
Guilin University of Aerospace Technology
2025
Children's Nutrition Research Center at Baylor College of Medicine
2018-2024
Chinese University of Hong Kong
2019-2024
Runze (China)
2024
Qilu University of Technology
2020-2021
Baylor Genetics
2018-2019
Guangzhou University of Chinese Medicine
2019
Baylor College of Medicine
2011-2019
Huashan Hospital
2019
Fudan University
2019
Age declines liver functions, leading to the development of age-associated diseases. A member sirtuins family, SIRT1, is involved in control glucose homeostasis and fat metabolism. Because aging livers have alterations metabolism, we examined a possible role SIRT1 these alterations. We found that aged reduced expression lost proper regulation after partial hepatectomy (PH). Down-regulation old mice mediated by CCAAT/Enhancer Binding Protein/histone deacetylase 1 (C/EBPβ-HDAC1) complexes,...
Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which one the main characteristics aging liver. Here, we present a molecular scenario age-related steatosis. We show that C/EBPα-S193D knockin mice have age-associated epigenetic changes and develop steatosis at 2 months age. underlying mechanism in old wild-type (WT) young S193D includes increased amounts tripartite p300-C/EBPα/β complexes...
One of the early events in development liver cancer is a neutralization tumor suppressor proteins Rb, p53, hepatocyte nuclear factor 4α (HNF4α), and CCAAT/enhancer binding protein (C/EBP) α. The elimination these mediated by small subunit proteasome, gankyrin, which activated cancer. aim this study was to determine mechanisms that repress gankyrin quiescent livers activation We found farnesoid X receptor (FXR) inhibits expression silencing promoter through HDAC1-C/EBPβ complexes. C/EBPβ key...
Liver cancer is the fifth most common cancer. A highly invasive surgical resection of liver tumor main approach used to eliminate tumor. Mechanisms that terminate regeneration when reaches original size are not known. The aims this work were generate an animal model fails stop after resections and elucidate mechanisms involved in termination regeneration. Because epigenetic control function has been previously implicated regulation proliferation, we generated C/EBPα‐S193A knockin mice, which...
Metastasis causes most deaths from cancer yet mechanistic understanding and therapeutic options remain limited. Overexpression of the phosphatase PRL-3 (phosphatase regenerating liver) is associated with metastasis colon cancer. Here, we show that a direct target signaling by TGFβ, which broadly implicated in progression metastasis. We found suppression expression TGFβ was mediated Smad-dependent inhibition transcription at level promoter activity. activation stimulated PI3K/AKT caused...
Impaired tumor cell antigen presentation contributes significantly to immune evasion. This study identifies Berbamine hydrochloride (Ber), a compound derived from traditional Chinese medicine, as an effective inhibitor of autophagy that enhances in cells. Ber increases MHC-I-mediated melanoma cells, improving recognition and elimination by CD8+ T Mutation Atg4b, which blocks autophagy, also raises MHC-I levels on the surface, further treatment with under these conditions does not increase...
The thermal performance of a lithium-ion battery pack for an electric vehicle by adding straight rib turbulators in cooling plate channels has been numerically investigated this paper and the numerical model validated experimental data, which exhibits satisfactory prediction accuracy. effects shapes, angles, spacings, irregular gradient arrangement configurations on flow heat transfer behaviors plates have thoroughly explored analyzed paper. In addition, ribbed was examined at actual...
The development of hepatoblastoma (HBL) is associated with failure hepatic stem cells (HSC) to differentiate into hepatocytes. Despite intensive investigations, mechanisms the HSC are not known. We found that oncogene Gankyrin (Gank) involved in inhibition differentiation via triggering degradation tumor suppressor proteins (TSPs) Rb, p53, C/EBPα and HNF4α. Our data show activation a repressor Gank, farnesoid X receptor, FXR, after initiation liver cancer by Diethylnitrosamine (DEN) prevents...
Abstract Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune neuropsychiatric disease. Brain access of anti-NMDAR autoantibody through the blood–brain barrier (BBB) essential for pathogenesis. Most previous animal models limit investigation etiologies BBB damage in patients. Methods In this study, we established novel humanized mouse model by intraperitoneal injection patients’ peripheral blood mononuclear cells (PBMCs) into BALB/c Rag2 −/− Il2rg Sirpα...
Previous studies have shown that various active components of licorice anticancer effects. However, few investigated the mechanism action in gastric cancer. The effect compounds on biological activity cancer cells was vitro (MKN-45 cells). Network pharmacology and molecular docking were used to predict potential targets against verify binding stability target proteins compounds. In addition, assessed using a mouse model licorice-active component (quercetin) effectively inhibited...
Celery seeds have been used as an effective dietary supplement to manage hyperuricemia and diminish gout recurrence. Xanthine oxidase (XOD), the critical enzyme responsible for uric acid production, represents most promising target anti-hyperuricemia in clinical practice. In this study, we aimed establish a method based on affinity ultrafiltration-liquid chromatography-mass spectrometry (UF-LC-MS) directly rapidly identify bioactive compounds contributing XOD-inhibitory effects of celery...
BackgroundBoth Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are members of the human gamma family: each is associated with various cancers. The majority AIDS-associated primary effusion lymphoma (PEL) co-infected both KSHV EBV. Dually-infected PELs selectively switch from latency to lytic replication either or EBV in response chemical stimuli. transcription activator (K-RTA) necessary sufficient for replication, while BZLF1 gene product (EBV-Z) a critical...
A modified algorithm is proposed in this study to correct time-varying mesh stiffness (TVMS) and transmission error (TE) helical gears considering tooth root transition curve. The parametric model of gear established by using the meshing principle hob order obtain accurate Moreover, a TE test rig set up compare theoretical experimental results. results improved are very similar compared traditional model, relative also small. In study, effect multi-parameters (e.g. pressure angle, position,...
To expand the clinical spectrum of lysyl-tRNA synthetase (
Epstein-Barr virus (EBV) infection is associated with several human malignancies. Interferon (IFN) regulatory factor 7 (IRF-7) has splicing variants, and at least the major variant (IRF-7A) oncogenic potential EBV transformation processes. IRF-7C an alternative only DNA-binding domain of IRF-7. Whether present under physiological conditions its functions in viral are unknown. In this report, we prove existence protein RNA certain cells conditions, find that high levels primary B vitro as...