A5100687847- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Functional Brain Connectivity Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
- Lipid metabolism and biosynthesis
- Recommender Systems and Techniques
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Circular RNAs in diseases
- Lung Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Diet and metabolism studies
- RNA Interference and Gene Delivery
- Handwritten Text Recognition Techniques
- Nanoplatforms for cancer theranostics
- Cell Image Analysis Techniques
- Renal and related cancers
Beijing Forestry University
2021-2025
Yangzhou University
2023-2025
Hong Kong Baptist University
2024-2025
Tianjin Medical University General Hospital
2020-2025
Huaiyin Institute of Technology
2023-2025
Xiamen University
2024-2025
Capital Medical University
2024
Jiangxi Agricultural University
2009-2024
Beijing University of Chemical Technology
2024
Sichuan University
2004-2024
Although both schizophrenia and gray matter volume (GMV) show high heritability, however, genes accounting for GMV alterations in remain largely unknown. Based on risk identified by the genome-wide association study of Schizophrenia Working Group Psychiatric Genomics Consortium, we used transcription-neuroimaging analysis to test that which these are associated with changes schizophrenia. For each brain tissue sample, expression profiles 196 were extracted from six donated normal brains...
We developed an efficient visible-light-mediated formal carbene insertion reaction of 1,3-diketones with diazoesters for the construction enantioenriched 1,4-dicarbonyl compounds a quaternary carbon center. Combining visible light and Brønsted acid catalyst, chiral were achieved in good yields high enantioselectivities by photochemical transfer protocol.
Neuroimaging studies have shown that schizophrenia is associated with disruption of resting-state local functional connectivity. However, these findings vary considerably, which hampers our understanding the underlying pathophysiological mechanisms schizophrenia. Here, we performed an updated and extended meta-analysis to identify most consistent changes connectivity measured by regional homogeneity (ReHo) in Specifically, a systematic search ReHo patients PubMed, Embase, Web Science...
Polysaccharides from Enteromorpha prolifera (EP) possess important benefits in the management of obesity and associated metabolic diseases, but to date, underlying mechanism linking this alleviative effect EP gut microbiota remains obscure. This study aimed investigate effects improving lipid metabolism disorders intestinal barrier disruption mice with high-fat diet (HFD), its association modulation microbiota. C57BL/6 were fed a control or HFD without 5% for 12 weeks. Factors related...
Autism spectrum disorders (ASDs) are a group of heterogeneous neurodevelopmental that highly heritable and associated with impaired dynamic functional connectivity (DFC). However, the molecular mechanisms behind DFC alterations remain largely unknown. Eighty-eight patients ASDs 87 demographically matched typical controls (TCs) from Brain Imaging Data Exchange II database were included in this study. A seed-based sliding window approach was then performed to investigate changes each 29 seeds...
Abstract Previous observational investigations suggest that structural and diffusion imaging-derived phenotypes (IDPs) are associated with major neurodegenerative diseases; however, whether these associations causal remains largely uncertain. Herein we conducted bidirectional two-sample Mendelian randomization analyses to infer the relationships between IDPs diseases using common genetic variants-single nucleotide polymorphism (SNPs) as instrumental variables. Summary statistics of...
CARM1, belonging to the protein arginine methyltransferase (PRMT) family, is intricately associated with progression of cancer and viewed as a promising target for both diagnosis therapy. However, number specific potent CARM1 inhibitors limited. We herein discovered inhibitor, iCARM1, that showed better specificity activity toward compared known inhibitors, EZM2302 TP-064. Similar knockdown, iCARM1 suppressed expression oncogenic estrogen/ERα-target genes, whereas activated type I interferon...
Successful human red blood cell cryopreservation techniques have been gradually developed in recent decades, with great potential for use clinical medicine and basic research. The mechanical properties of a single are important clues to reveal the physiological pathological state cell, but they not used assess after cryopreservation. Herein, we investigated effects processes on biomechanics by means microfluidic, label-free, synchronous, nondestructive electrodeformation assay. We found that...
Bradykinesia, a debilitating symptom characterized by impaired movement initiation and reduced speed in Parkinson's disease (PD), is associated with abnormal oscillatory activity the motor cortex-basal ganglia circuit. We investigated interplay between beta gamma oscillations relation to bradykinesia parkinsonian rats. Our findings showed activities rats, accompanied enhanced high cortex, which are closely transitional difficulties. Additionally, correlated velocity control rats but not...
Abstract Pancreatic cancer is a highly malignant and metastatic cancer. can lead to liver metastases, gallbladder duodenum metastases. The identification of pancreatic cells essential for the diagnosis exploration carcinoma in situ. Organelles play an important role maintaining function cells, various show significant differences organelle microenvironment. Herein, six probes are synthesized targeting mitochondria, lysosomes, cell membranes, endoplasmic reticulum, Golgi apparatus, lipid...
Spatially resolved transcriptomics (SRT) data provide critical insights into gene expression patterns within tissue contexts, necessitating effective methods for identifying spatial domains. We introduce stDyer, an end-to-end deep learning framework domain clustering in SRT data. stDyer combines Gaussian Mixture Variational AutoEncoder with graph attention networks to learn embeddings and perform clustering. Its dynamic graphs adaptively link units based on assignments, improving producing...
Chloroplasts are vital for photosynthesis, and their development necessitates proper expression of chloroplast genes. However, the regulatory mechanisms underlying rice gene have not been fully elucidated. In this study, we obtained an albino mutant rice, white seedling lethal 1 (wsl1), which displays significantly decreased chlorophyll contents impaired ultrastructure. The causal Oryza sativa PEP-RELATED DEVELOPMENT ARRESTED (OsPRDA1) was isolated using Mutmap + verified by editing...