A5101445759- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Bioinformatics and Genomic Networks
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cognitive and developmental aspects of mathematical skills
- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Sleep and related disorders
- Ophthalmology and Eye Disorders
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Autism Spectrum Disorder Research
- Vestibular and auditory disorders
- Fractal and DNA sequence analysis
- Eating Disorders and Behaviors
- Neuroscience, Education and Cognitive Function
- Inhalation and Respiratory Drug Delivery
- Infectious Encephalopathies and Encephalitis
Sichuan University
2018-2025
West China Hospital of Sichuan University
2018-2025
Capital Medical University
2024
Ministry of Education of the People's Republic of China
2024
Southwest University
2024
Air Force Medical University
2021-2022
Tianjin Medical University Cancer Institute and Hospital
2021-2022
Tang Du Hospital
2022
University of Electronic Science and Technology of China
2020
Tianjin Medical University General Hospital
2007-2013
The human frontal pole (FP) approximately corresponds to Brodmann's area 10 and is a highly differentiated cortical with unique cytoarchitectonic characteristics. However, its functional diversity suggestive of the existence subregions. Based on anatomical connection patterns derived from diffusion tensor imaging data, we applied spectral clustering algorithm parcellate right FP into orbital (FPo), lateral (FPl), medial (FPm) This parcellation scheme was validated by corresponding analyses...
Autism spectrum disorders (ASDs) are a group of heterogeneous neurodevelopmental that highly heritable and associated with impaired dynamic functional connectivity (DFC). However, the molecular mechanisms behind DFC alterations remain largely unknown. Eighty-eight patients ASDs 87 demographically matched typical controls (TCs) from Brain Imaging Data Exchange II database were included in this study. A seed-based sliding window approach was then performed to investigate changes each 29 seeds...
To explore the dynamic changes of white matters following anterior temporal lobectomy (ATL) in mesial lobe epilepsy (MTLE) patients who achieved seizure-free at two-year follow-up. Diffusion tensor imaging (DTI) was obtained ten MTLE five serial time points: before surgery, three months, six 12 months and 24 after as well 11 age- sex-matched healthy controls one point. Regions with significant postoperative fractional anisotropy (FA) their were confirmed by comparing all preoperative data...
Temporal lobe epilepsy (TLE) has been recognized as a network disorder with widespread gray matter atrophy. However, the role of connectome architecture in shaping morphological alterations and identifying atrophy epicenters remains unclear. Furthermore, individualized modeling their potential clinical applications have not well established. This study aims to explore how correlates normal architecture, identify epicenters, employ approach evaluate impact different epicenter patterns on...
The cerebellum contains several cognitive-related subregions that are involved in different functional networks. cerebellar crus II is correlated with the frontoparietal network (FPN), whereas IX associated default-mode (DMN). These two networks anticorrelated and cooperatively implicated cognitive control, which may facilitate motor recovery stroke patients. In present study, we aimed to investigate resting-state connectivity (rsFC) changes 25 subcortical ischemic patients well-recovered...
The purpose of this study was to assess the differences topological characteristic and rich club organization between temporal lobe epilepsy (TLE) patients with focal seizure (FS) only those bilateral tonic-clonic seizures (FBTCS).We recruited 130 unilateral TLE patients, which 57 FS 73 both FBTCS, 68 age- gender-matched healthy controls (HC). Whole-brain networks were constructed based on diffusion weighted imaging data. Graph theory applied quantify network metrics organization....
Although recent evidence indicates an association between gene co-expression and functional connectivity in human brain, specific patterns remain largely unknown. Here, using neuroimaging-based data of living brains brain-wide expression postmortem brains, we performed comprehensive analyses to dissect relationships connectivity. We identified 125 connectivity-related genes (20 novel genes) enriched for dendrite extension, signaling pathway schizophrenia, 179 gene-related connections mainly...
Mesial temporal lobe epilepsy (mTLE) is a complex neurological disorder that has been recognized as widespread global network disorder. The group-level structural covariance (SCN) could reveal the connectivity disruption of mTLE but not reflect heterogeneity at individual level.
Abstract Objective The single‐center retrospective cohort study investigated underlying pathogenic mechanisms and clinical significance of patients with temporal lobe epilepsy hippocampal sclerosis (TLE‐HS), in the presence/absence gray–white matter abnormalities (usually called “blurring”; GMB) ipsilateral temporopolar region (TPR) on MRI. Methods involved 105 unilateral TLE‐HS (60 GMB+ 45 GMB−) who underwent standard anterior lobectomy, along 61 healthy controls. Resected specimens were...
ABSTRACT Background Focal to bilateral tonic–clonic seizures (FBTCS) represent the most severe seizure type in temporal lobe epilepsy (TLE), associated with extensive network abnormalities. Nevertheless, genetic and cellular factors predispose specific TLE patients FBTCS remain poorly understood. This study aimed elucidate relationship between brain morphometric alterations transcriptional profiles (FBTCS+) compared those without (FBTCS−). Methods We enrolled 126 unilateral (89 FBTCS+ 37...
To investigate the optic radiation disruption in children ametropic, anisometropic and strabismic amblyopia. Methods: The fractional anisotropy (FA) values, average diffusion coefficient (DCavg) values neural fiber tracts of radiations amblyopic groups healthy group were measured compared by tensor imaging (DTI) with Tractography (DTT). Results: FA bilateral three lower significantly than that group; while difference DCavg between was insignificant. And decreased fibers amblyopia showed DTT,...
<h3>BACKGROUND AND PURPOSE:</h3> Exploring the directionality of neural information in brain is important for understanding mechanisms and neurodisease development. Granger causality analysis metabolic connectivity map can be used to investigate directional transmission between regions, but their differences depicting functional effective are not clear. <h3>MATERIALS METHODS:</h3> Using Monash rs-PET/MR imaging data set, we conducted analyses dopamine reward circuit brain. The a well-known...
Objective: To investigate the functional deficit of brain cortex in human ametropic amblyopia. Methods: The regional activation amblyopia and healthy subjects evoked by visual stimuli red-black green-black chessboard patterns were detected blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI) based on block-design event-related design. Results: major activated regions during stimulation with modal both amblyopic groups; While under design modal, showed areas...