A5017834984- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone Tissue Engineering Materials
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Dental Implant Techniques and Outcomes
- Pharmacological Effects and Toxicity Studies
- Periodontal Regeneration and Treatments
- Retinoids in leukemia and cellular processes
- Vascular Malformations Diagnosis and Treatment
- Additive Manufacturing and 3D Printing Technologies
- Spinal Hematomas and Complications
- Vascular Malformations and Hemangiomas
- Cancer Research and Treatments
- Advanced Image Fusion Techniques
- Neurofibromatosis and Schwannoma Cases
- dental development and anomalies
- Brain Tumor Detection and Classification
- EEG and Brain-Computer Interfaces
- Microtubule and mitosis dynamics
- Moyamoya disease diagnosis and treatment
Sichuan University
2013-2024
West China Hospital of Sichuan University
2012-2024
State Key Laboratory of Biotherapy
2021
Abstract Artificial intelligence provides an opportunity to try redefine disease subtypes based on similar pathobiology. Using a machine-learning algorithm (Subtype and Stage Inference) with cross-sectional MRI from 296 individuals focal epilepsy originating the temporal lobe (TLE) 91 healthy controls, we show phenotypic heterogeneity in pathophysiological progression of TLE. This study was registered Chinese Clinical Trials Registry (number: ChiCTR2200062562). We identify two...
Growing evidence indicates that tumor suppressor gene TP-53 and non-coding RNA miR-34b/c independently and/or jointly play crucial roles in carcinogenesis. We hypothesized the polymorphisms of rs4938723 promoter region pri-miR-34b/c Arg72-Pro may be related to risk nasopharyngeal carcinoma (NPC). performed a case-control study between 217 patients with NPC 360 healthy controls Chinese population using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A...
Abstract Hard tissue engineering scaffolds especially 3D printed were considered an excellent strategy for craniomaxillofacial hard regeneration, involving crania and facial bones teeth. Porcine treated dentin matrix (pTDM) as xenogeneic extracellular has the potential to promote stem cell differentiation mineralization it contains plenty of bioactive factors similar with human-derived tissue. However, its application might be impeded by foreign body response induced damage-associated...
β‑amyloid precursor protein (β‑APP), also known as Aβ peptide, has a key role in the pathogenesis of Alzheimer's disease, and is likely to be involved development refractory epilepsy. The mechanism behind association between β‑APP epilepsy remains elucidated. aim present study was examine levels APP mRNA patients with Tissue samples were obtained from chronic pharmacoresistant who underwent surgery. Levels epileptic temporal lobe hippocampal tissue assessed using quantitative polymerase...
Neuroinflammation is considered an important step in the progression of secondary brain injury (SBI) induced by cerebral hemorrhage (ICH). The nucleotide-binding and oligomerization structural domain-like receptor family pyridine domain-containing 3 (NLRP3) inflammasomes play role immune pathophysiology SBI. Febuxostat (Feb) a xanthine oxidase inhibitor that approved for treatment gout has been found to have potent anti-inflammatory effects. However, it less studied after ICH we aimed...
Recent advances in 3D printing offer a prospective avenue for producing transplantable human tissues with complex geometries; however, the appropriate 3D-printed scaffolds possessing biological compatibility tooth regeneration remain unidentified. This study proposes personalized scaffold of multiple bioactivities, including induction stem cell proliferation and differentiation, biomimetic mineralization, angiogenesis. A brand-new bioink system comprising biocompatible biodegradable polymer...
Growing evidence has shown that nuclear factor-κB (NF-κB) plays a key role in the initiation and progression of systemic lupus erythematosus (SLE) pathogenesis. A common polymorphism (-94 insertion/deletion ATTG, rs28362491) promoter region NFKB1 gene was identified as functional. The -94del ATTG allele exhibited loss binding to proteins resulted reduced activity. We investigated association between -94 risk SLE. total 224 SLE patients 256 control subjects were genotyped using polymerase...
Several lines of evidence indicate that inflammatory processes play a key role in the happening and development intracranial aneurysm (IA). Recently, polymorphisms TP53 gene were shown to be associated with inflammation disease. The aim this study was investigate interactions miR-34b/c Arg72-Pro on risk IA Chinese population. A total 590 individuals (including 164 patients 426 controls) involved study. (i.e., rs4938723 Arg72-Pro) genotyped by polymerase chain reaction-restriction fragment...
MicroRNAs (miRs)-143/145 are involved in various biological processes related to aneurysm formation and downregulated patients with intracranial (IA). We aimed determine whether two functional polymorphisms (i.e. rs4705342 rs4705343) the promoter of miR-143/145 IA risk. A case-control study was undertaken examine association rs4705343 risk, including 565 622 age- gender-matched controls. analysed by TaqMan Assay, genotyped using polymerase chain reaction-restriction fragment length...
Emerging evidence from preclinical and clinical studies has shown that interleukin-12 (IL-12) some effectiveness against endogenously arising brain tumor. The aim of this study was to investigate interactions IL-12A IL-12B polymorphisms on the risk We analyzed rs2243115 rs3212227 in 170 patients with tumor 222 healthy controls a Chinese population using polymerase chain reaction-restriction fragment length polymorphism assay DNA sequencing method. Individuals carrying G allele had...
Let-7 family plays a key role in the progression of atherosclerosis and intracranial aneurysm (IA). We hypothesized that rs10877887 rs13293512 polymorphisms promoters let-7 may be associated with susceptibility IA. genotyped 2 single nucleotide (SNPs) 305 patients IA 401 healthy controls. The was analyzed using polymerase chain reaction-restriction fragment length polymorphism assay, TaqMan SNP genotyping method. relative expression measured plasma cases controls real-time PCR. found...
To investigate the effect of aligner displacement on tooth movement and periodontal health to improve efficiency treatment explore mechanism in vivo.A two-tooth site was established by a finite element (FE) model virtually evaluate staging. A randomized controlled experiment conducted when sites beagles were treated with fixed or appliances different force, internal structure recorded during alignment. After sacrificing five dogs, bone-periodontal ligament (PDL)-tooth specimens removed...
Hard tissues, especially teeth and bones, are highly mineralized the large-scale defect or total loss of them is irreversible. There still no ideal strategy for reconstruction various hard tissue defects that can achieve balance between biological mechanical properties. Polyether ether ketone (PEEK) has potential to substitute natural in areas but limited by its inertness. The addition hydroxyapatite (HA) significantly improve osteogenic properties osteointegration PEEK materials. But...
Background Hippocampal sclerosis (HS) is the most common pathological type of temporal lobe epilepsy (TLE) and one important surgical markers. Currently, HS mainly diagnosed manually by radiologists based on visual inspection MRI, which greatly relies MRI quality physician experience. In clinical practice, non-thin scans are often used due to time efficiency needed for acquisition. However, these can be difficult junior physicians interpret accurately. Thus, rapid accurate diagnosis using...
Growing evidence indicates that vascular inflammation is a common phenomenon in the pathogenesis of intracranial aneurysms (IAs). Nuclear factor kappa B key molecule involved IA. We hypothesized an insertion/deletion (ins/del) ATTG polymorphism located between two putative promoter regulatory elements NFKB1 gene may be related to risk IA.We performed case-control study, including 164 patients with IA and 525 healthy controls Chinese population using polymerase chain reaction-polyacrylamide...
Objective: Glutathione S-transferases (GSTs) are important enzymes that involved in detoxification of environmental carcinogens. Molecular epidemiological studies have been conducted to investigate the association between GSTM1 and GSTT1 homozygous deletion polymorphisms brain tumours but results conflicting. The aim this study was clarify problem using a meta-analysis. Methods: A total 9 records were identified by searching PubMed Embase databases. Fixed- random-effects models performed...