A5100645394- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- CRISPR and Genetic Engineering
- Immunodeficiency and Autoimmune Disorders
- Cellular Mechanics and Interactions
- Chromosomal and Genetic Variations
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Genomics and Phylogenetic Studies
- Atmospheric and Environmental Gas Dynamics
- RNA Interference and Gene Delivery
- Nicotinic Acetylcholine Receptors Study
- Chemical synthesis and alkaloids
- T-cell and Retrovirus Studies
- Cell Adhesion Molecules Research
Baylor College of Medicine
2015-2024
Neurological Research Institute
2014-2024
University of Lincoln
2024
University of Maryland Center for Environmental Science
2023
Aerodyne Research
2004-2023
University of Edinburgh
2023
Arizona State University
2022
University of Cape Town
2022
Canadian Mennonite University
2022
AARP
2021
With the use of an enzyme-linked immunoabsorbent assay to measure soluble human interleukin 2 receptors (IL 2R), certain T cell leukemia virus I (HTLV I)-positive lines were found spontaneously release large quantities IL 2R into culture supernatants. This was not with HTLV I-negative and independent lines, only one seven B cell-derived examined produced small amounts 2R. In addition this constitutive production by normal peripheral blood mononuclear cells (PBMC) could be induced plant...
Fragile X syndrome is the most frequent form of inherited mental retardation and segregates as an X-linked dominant with reduced penetrance. Recently, we have identified FMR-1 gene at fragile locus. Two molecular differences been found in patients: a size increase exon containing CGG repeat abnormal methylation CpG island 250 bp proximal to this repeat. Penetrant males who exhibit these changes typically show repression transcription presumptive absence protein believed contribute phenotype....
Current efforts to map the human genome are focused on individual chromosomes or smaller regions and frequently rely use of somatic cell hybrids. We report application polymerase chain reaction direct amplification DNA from hybrid cells containing in rodent backgrounds using primers directed Alu repeat element. demonstrate Alu-directed a fragment HPRT gene both cloned identify through sequence analysis repeats involved this amplification. also technique chromosomal locations large fragments...
Sialic acids are important cell-surface molecules of animals in the deuterostome lineage. Although humans do not express easily detectable amounts N-glycolylneuraminic acid (Neu5Gc, a hydroxylated form common sialic N-acetylneuraminic acid, Neu5Ac), it is major component great ape tissues, except brain. This difference correlates with lack hydroxylase activity that converts CMP-Neu5Ac to CMP-Neu5Gc. Here we report cloning human and chimpanzee cDNAs. this cDNA similar murine homologue,...
Wiskott-Aldrich syndrome protein (WASp) is a hematopoietic-specific, multidomain whose mutation responsible for the immunodeficiency disorder syndrome. WASp contains binding motif Rho GTPase CDC42Hs as well verprolin/cofilin-like actin-regulatory domains, but no specific actin structure regulated by CDC42Hs-WASp has been identified. We found that colocalizes with and in core of podosomes, highly dynamic adhesion human blood-derived macrophages. Microinjection constitutively active V12CDC42Hs...
The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and determine functional capacity. Enzymatic digestions demonstrated that the IL 2R, like cell surface is a complex glycoprotein, modified by addition of both N- O-linked carbohydrates sialic acid residues. It has peptide backbone approximately 10 Kd smaller than membrane-associated counterpart. Affinity chromatography 2R from either an HTLV-I-positive T line (HUT-102) or...
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share phenotypic pathologic overlap. Recently, an expansion of GGGGCC repeats in the first intron C9orf72 was found to be a common cause both illnesses; however, molecular pathogenesis this expanded repeat is unknown. Here we developed Drosophila mammalian models hexanucleotide showed that expression RNA (rGGGGCC) sufficient neurodegeneration. We further identified Pur α as RNA-binding protein rGGGGCC discovered interact...
Postmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and translation take place at separate developmental stages, but how mRNAs stored as translationally inert messenger ribonucleoproteins developing become activated remains largely unknown. Here, we report that the RNA binding protein FXR1, member of fragile X-related (FXR) family, is highly expressed late undergoes liquid-liquid phase separation (LLPS) merge...