A5081533782- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Virus-based gene therapy research
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- Cardiac electrophysiology and arrhythmias
- bioluminescence and chemiluminescence research
- Ion channel regulation and function
- Advanced Battery Technologies Research
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- Medical Imaging Techniques and Applications
- Advancements in Battery Materials
- Viral Infectious Diseases and Gene Expression in Insects
- Neurological disorders and treatments
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
University of California, San Diego
1992-2023
AntiCancer (United States)
2000-2023
Colorado School of Mines
2020-2023
Memorial Sloan Kettering Cancer Center
2002
Anticancer Fund
2001
University of California San Diego Medical Center
1999
Ewing's sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics.The aim this study was to investigate the efficacy tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting oral administration recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model.The PDOX models were previously established right chest wall. The randomized into 5 groups when volume reached 80 mm3: G1: untreated control; G2:...
L-Methionine-alpha-deamino-gamma-mercaptomethane lyase (rMETase) is involved in the alpha,gamma-elimination of methionine to alpha-ketobutyrate, methanethiol and ammonia. The reaction catalyzed by rMETase reduces concentration methionine-dependent tumor cells, arresting their growth. Towards goal developing into an effective antitumor therapeutic also understand catalytic mechanism this enzyme, from Pseudomonas putida has been expressed, purified crystallized. crystals belong space group...
Widely practiced Li-ion battery models, such as pseudo-two-dimensional (P2D) models [1-3], use representative spherical electrode particles with assumed isotropic transport properties. Electrode particles, NMC, are typically composites that comprised of numerous randomly oriented crystallites. Each the single-crystal primary compose secondary particle can have strongly anisotropic properties affect intercalation process. The empirically approximated effective (e.g., diffusion coefficients)...
A model-based understanding can assist and accelerate developing all-solid-state batteries (ASSB). In addition to chemo-mechanical influences within electrode particles (e.g., NMC) [1-2], a solid electrolyte argyrodites) introduces additional interfacial interactions between phases [3-5]. The present research derives implements coupled multi-physics finite-element model that captures electrochemical, transport, structural behaviors of composite structures. models incorporate...
Cimetidine, a histamine type 2 (H2) receptor antagonist, is commonly prescribed medication for the treatment of gastroesophageal reflux disease (GERD) as well gastric and duodenal ulcer disease. In addition, cimetidine has been shown to have immunomodulatory effects. This led investigators study effects in various neoplasms. Chemotherapy colon cancer based on fluorouracil, which only minimal activity high-stage Pharmacologic agents that can improve survival patients with will profound impact...
Background Chemoresponse is a significant outcome predictor in patients with head and neck cancer, regardless of the treatment modality used. The histoculture drug response assay (HDRA) has been shown to be reliable method for vitro chemoresponse assessment. In this study, we have correlated HDRA assessment survival squamous cell carcinoma (HNSCC). Method Tumor specimens from 41 42 undergoing HNSCC were successfully evaluated by HDRA. tissue was histocultured on Gelfoam sponges gel 24-well...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEasily constructed tangent meterRobert M. Hoffman Cite this: J. Chem. Educ. 1934, 11, 626Publication Date (Print):November 1, 1934Publication History Received3 August 2009Published online1 November 1934Published inissue 1 1934https://doi.org/10.1021/ed011p626RIGHTS & PERMISSIONSArticle Views23Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since 2008 (both PDF and HTML) across...
Supplementary Movie 2 from Whole-Body Subcellular Multicolor Imaging of Tumor-Host Interaction and Drug Response in Real Time
<div>Abstract<p>In the present report, we show real-time imaging of cancer cell trafficking in lymphatic vessels. Cancer cells labeled with both green fluorescent protein (GFP) nucleus and red (RFP) cytoplasm or GFP only RFP were injected into inguinal lymph node nude mice. The trafficked through vessels where they imaged via a skin flap real time at cellular level until entered axillary node. bright fluorescence microscopic capability Olympus OV100 small-animal system enabled...
Supplementary Movie 1 from Whole-Body Subcellular Multicolor Imaging of Tumor-Host Interaction and Drug Response in Real Time
Supplementary Movie 3 from Real-time Imaging of Tumor-Cell Shedding and Trafficking in Lymphatic Channels
Supplementary Movie 1 from Real-time Imaging of Tumor-Cell Shedding and Trafficking in Lymphatic Channels
Supplementary Movie 2 from Real-time Imaging of Tumor-Cell Shedding and Trafficking in Lymphatic Channels
Supplementary Movie 3 from Real-time Imaging of Tumor-Cell Shedding and Trafficking in Lymphatic Channels
<div>Abstract<p>In the present report, we show real-time imaging of cancer cell trafficking in lymphatic vessels. Cancer cells labeled with both green fluorescent protein (GFP) nucleus and red (RFP) cytoplasm or GFP only RFP were injected into inguinal lymph node nude mice. The trafficked through vessels where they imaged via a skin flap real time at cellular level until entered axillary node. bright fluorescence microscopic capability Olympus OV100 small-animal system enabled...