A5021462550- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Musculoskeletal synovial abnormalities and treatments
- Reconstructive Surgery and Microvascular Techniques
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Spine and Intervertebral Disc Pathology
- Colorectal and Anal Carcinomas
- Head and Neck Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Lymphoma Diagnosis and Treatment
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Surgical site infection prevention
- Tumors and Oncological Cases
- Chemotherapy-induced organ toxicity mitigation
- Urologic and reproductive health conditions
- Childhood Cancer Survivors' Quality of Life
- Bone health and treatments
- Ear and Head Tumors
Gifu University
2016-2025
Orthopedic One
2016-2023
National Cancer Center
2010
PURPOSE Our previous NECO phase II studies on high-grade osteosarcoma suggested that administering ifosfamide (IF; 16 g/m 2 [4g/m once day 1, then 2g/m days 2-7] × six) to patients showing a poor response (PrRsp) preoperative chemotherapy with methotrexate, doxorubicin, and cisplatin (MAP) improves their prognoses. In this Japan Clinical Oncology Group (JCOG) study, JCOG0905, we aimed investigate the efficacy safety of IF in PrRsp. METHODS JCOG0905 is multicenter, open-label,...
Pediatric and adolescent/young adult (AYA) cancer patients face profound psychological challenges, exacerbated by limited access to continuous mental health support. While conventional therapeutic interventions often follow structured protocols, the potential of generative artificial intelligence (AI) chatbots provide conversational support remains unexplored. This study evaluates feasibility impact AI in alleviating distress enhancing treatment engagement this vulnerable population. Two...
Giant cell tumor of bone (GCTB) is an intermediate known to be locally aggressive, but rarely metastasizing. To plan a prospective study GCTB, we performed questionnaire survey for institutions participating in the Bone and Soft Tissue Tumor Study Group (BSTTSG) Japan Clinical Oncology (JCOG) 2015. We reviewed 158 consecutive patients with primary GCTB treated curettage without perioperative denosumab from 2008 2010 Japan. investigated local distant recurrence rates after definitive...
Pseudomyogenic hemangioendothelioma (PMH) is a recently described vascular neoplasm that occurs most commonly in the soft tissue of distal extremities young adults. Metastatic PMH can be fatal and there are no effective medications. We describe case 15-year-old boy with metastatic PMH, who responded to treatment everolimus, mammalian target rapamycin inhibitor. Immunohistochemistry showed was expressed biopsy specimens, which may explain reduction tumor size following treatment.
EWS-Fli1, a fusion gene resulting from the chromosomal translocation t(11;22, q24;q12), encodes transcriptional activator, promotes cellular transformation, and is often found in Ewing sarcoma primitive neuroectodermal tumor. The Aurora A B kinases belong to highly conserved family of serine/threonine protein kinases, are tightly regulated during cell cycle, overexpressed many carcinomas. Because relationship between and/or genes EWS-Fli1 unknown, we investigated regulatory mechanism(s) by...
The EWS/Fli-1 fusion gene, a product of the translocation t(11;22, q24;q12), is detected in 85% Ewing sarcomas and primitive neuroectodermal tumors. It thought to be transcriptional activator that plays significant role tumorigenesis. In this study, we developed novel blockade system using RNA interference tested its application for inhibiting proliferation sarcoma cells vitro treatment mouse tumor xenografts vivo. We designed synthesized small interfering (siRNA) possessing an aromatic...
Soft-tissue sarcomas (STS) are rare malignant tumors those resistant to chemotherapy. We have previously reported the 3-year follow-up result on efficacy of perioperative chemotherapy with doxorubicin (DXR) and ifosfamide (IFM) for high-risk STS extremities (JCOG0304). In present study, we analyzed 10-year results JCOG0304.Patients operable, (T2bN0M0, AJCC 6th edition) were treated 3 courses preoperative 2 postoperative chemotherapy, which consisted 60 mg/m2 DXR plus 10 g/m2 IFM over a...
Abstract Background Tumor-devitalized autografts treated with deep freezing, pasteurization, and irradiation are biological reconstruction methods after tumor excision for aggressive or malignant bone soft tissue tumors that involve a major long bone. do not require bank, they carry no risk of viral bacterial disease transmission, associated smaller immunologic response, have better shape size match to the site in which implanted. However, disadvantages as well; it is possible assess margins...
This study investigated the potential of metaverse in providing psychological support for pediatric and AYA cancer patients, with a focus on those rare cancers. The research involved ten patients survivors from four distinct regions Japan, who participated sessions using customizable avatars, facilitating interactions across geographical temporal barriers. Surveys qualitative feedback were collected to assess psychosocial impact intervention. results demonstrated that enabled connect peers,...
To elucidate the magnetic resonance imaging (MRI) characteristics for distinguishing solitary fibrous tumors (SFTs) from desmoid (DTs). A retrospective study of 66 consecutive patients with histopathologically proven SFT (n = 34; 13 males and 21 females; mean age, 52.0 ± 17.1 years) or DT 32; 11 39.0 21.3 was conducted. The two groups were quantitatively compared in terms size, signal intensity ratio (SIR), apparent diffusion coefficient value. For qualitative analysis, tumor location,...
The proximal femoral nail antirotation is a new generation of intramedullary device for the treatment trochanteric fractures, having helical blade rather than screw suggested better purchase in osteoporotic bone. However, it not free complications. Few reports are available on postoperative perforation through head as unique complication antirotation. We report 79-year-old woman with acetabular after migration an unstable fracture, which was fixed
Kasabach-Merritt phenomenon (KMP) is a life-threatening consumptive coagulopathy associated with underlying kaposiform hemangioendothelioma (KHE) in infancy. We describe the case of 3-month-old girl KHE complicated by KMP who responded dramatically to treatment everolimus, mechanistic target rapamycin (mTOR) inhibitor. Immunohistochemical expression mTOR was found biopsy specimens, which may explain improvement and reduction tumor size inhibitor treatment. This effective use everolimus shed...
This randomised phase II/III trial aimed to determine whether perioperative chemotherapy with gemcitabine plus docetaxel (GD) is non-inferior the standard Adriamycin ifosfamide (AI) in terms of overall survival (OS) patients soft tissue sarcoma (STS).Patients localised high-risk STS extremities or trunk were receive AI GD. The treatments repeated for three preoperative and two postoperative courses. primary endpoint was OS.Among 143 enrolled who received (70 patients) compared GD (73...
Background/Aim: We aimed to confirm predictors of survival in soft-tissue sarcoma (STS) patients with metastatic disease at initial presentation 9 Institutions under the Tokai Musculoskeletal Oncology Consortium. Patients and Methods: Between 2008 2013, 47 STS were referred for treatment. The mean follow-up duration was 24 months. Results: C-reactive protein (CRP) levels 2.47 mg/dl. hemoglobin albumin 13.1 g/dl 4.1 g/dl, respectively. Hemoglobin significantly correlated CRP levels. In...
This study aimed to evaluate the efficacy of using MRI findings differentiate superficial spindle cell lipomas (SCLs) from atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDLs).
Vascular endothelial growth factor (VEGF)-A plays an important role in the pathological angiogenesis that occurs soft-tissue sarcoma and about half of Ewing's cases, where it is highly overexpressed. EWS/Fli-1 considered to be a transcriptional activator play significant tumorigenesis sarcoma. However, relationship between VEGF-A still unclear. The aim this research investigate VEGF-A, determine whether small interfering RNA (siRNA)-targeting can developed as novel treatment for Knockdown...
Bone and soft tissue sarcomas (BSTS) are rare malignant tumors. Recently, the combination of gemcitabine docetaxel (GD) was shown to have activity as second-line setting in BSTS. However, efficacy first-line adjuvant settings precise profiles adverse events Japanese patients not known yet. In present study, feasibility GD with BSTS were investigated. Patients treated our institutions retrospectively analyzed. Information regarding clinical features, events, outcome collected statistically...
Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it still unclear which set criteria would show the best association with pathological and survival patients STS.We compared responses to operable by Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association Choi analyzed...
The objective of this work was to investigate the osteogenetic ability human dental pulp stem cells (hDPSCs) derived from third molars. We induced alkaline phosphatase (ALP) activity and bone morphogenetic protein 2 (BMP-2) mRNA expression, markers for formation, in hDPSCs by using osteoinductive factors. implantation with collagen sponge promoted osteogenesis fracture healing femur an immunocompromised rat, which a defect model pseudoarthrosis. Histological analyses revealed that after...