A5054469137- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Orthopaedic implants and arthroplasty
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Total Knee Arthroplasty Outcomes
- Oral and Maxillofacial Pathology
- Cardiac tumors and thrombi
- Histone Deacetylase Inhibitors Research
- Immune Response and Inflammation
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Orthopedic Infections and Treatments
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Heterotopic Ossification and Related Conditions
- Rheumatoid Arthritis Research and Therapies
- Peptidase Inhibition and Analysis
Hyogo Medical University
2013-2023
Hyogo University
2007-2023
Orthopedic One
2007-2009
Japan Clinical Cancer Research Organization
2008
Cleveland Clinic
2000
Skeletally immature children with a primary malignant tumor in the distal end of femur are candidates for limb-salvage surgery; however, functional impairment due to subsequent limb-length discrepancy must be considered. Our aim was evaluate long-term clinical outcome limb salvage patients sarcoma who were eleven years old or less, focusing on and complications.The cases forty retrospectively reviewed multicenter study based responses questionnaire. Twenty-eight had endoprosthetic...
Abstract Background Osteochondroma is the most common benign bone tumor in scapula. This condition might lead to snapping scapula syndrome, which characterized by painful, audible, and/or palpable abnormal scapulothoracic motion. In present case, this syndrome was successfully treated use of endoscopically assisted resection osteochondroma. Case presentation A 41-year-old man had a tolerable pain his scapular region over 10 years' period. The developed gradually with shoulder motion,...
Tumor cells express NKG2D ligands on their cell surface, which are the of activating receptor, NKG2D, that is expressed surface NK cells. The binding to tumor through interaction and its induces cytolysis In present study, we investigated effects hypoxia expression human osteosarcoma using three lines. To produce hypoxic normoxic conditions, lines were cultured under 1 20% O2 respectively. such as MHC class I-related chain molecules A B (MICA MICB) UL16-binding proteins 1, 2 3 (ULBP 3). MICA...
Processes in the repair of a crevice knee joint meniscus were investigated 10 dogs. Two 2‐mm cylindrical plugs from each medial removed, rendered acellular by freezing and thawing, then reinserted into meniscus. Dogs euthanized at intervals 3–52 weeks after surgery. The between plug 3 surgery was filled with tissue containing α‐smooth muscle actin‐positive cells. One year surgery, had remodeled populated spindle‐shaped fibrochondrocyte‐like an appearance intermediate that hyaline...
Osteoarthritis (OA) is characterized by articular cartilage degradation and hypertrophic joint changes. Interleukin (IL)-18 a potent inducer of prostaglandin (PG) E2 in vitro. We determined the relation between IL-18 PGE2 synovial fluid (SF) human OA, discussed role pathogenesis OA also its therapeutic consequences. SF was collected from 30 patients with knee OA. The concentrations other cytokines including IL-1β, tumor necrosis factor (TNF)-α, IL-6, IL-8 were measured enzyme-linked...
α‐Galactosylceramide (α‐GalCer) shows antitumor effects by activating natural killer (NK) cells indirectly through stimulation of the secretion cytokines NKT cells, whereas interleukin (IL)‐18 NK directly. In present study, we examined effect combined administration α‐GalCer and IL‐18. An injection cell‐sensitive mouse B16 melanoma into a tail vein produced pulmonary metastasis. The daily or IL‐18 alone for 4 days starting 1 day after markedly suppressed number metastatic foci, their...
To review cases of bone and soft tissue tumours the feet managed at Hyogo College Medicine, Nishinomiya Takarazuka Municipal Hospital, Takarazuka, Japan.Retrospective analysis 83 patient records treated for between 1974 2000.There were 33 benign tumours, one primary malignant tumour, 2 metastatic cancer. Marginal resection was performed in osteochondroma curettage other tumour. Despite below-knee amputation case chondrosarcoma, died because pulmonary metastasis. Two patients with cancer also...
Abstract Objective To generate a mouse model of reactive arthritis (ReA), an aseptic synovitis that develops in joints distant from the primary bacterial infection site, to examine roles for Toll‐like receptors (TLRs) recognize components involved development this arthritis, and identify cytokine(s) relevant arthritis. Methods Mice were treated with cell wall extract Escherichia coli (ECW) gram‐negative bacterium by injection into footpads. Seven days later, mice challenged...
The level of vascular endothelial growth inhibitor (VEGI) has been reported to be negatively associated with neovascularization in malignant tumors. soluble form VEGI is a potent anti-angiogenic factor due its effects inhibiting cell proliferation. This inhibition mediated by death receptor 3 (DR3), which contains domain cytoplasmic tail capable inducing apoptosis that can subsequently blocked decoy (DcR3). We investigated the sodium valproate (VPA) and trichostatin A (TSA), histone...
Abstract Background Clear cell chondrosarcoma is an extremely rare subtype; thus, its treatment outcomes and associated factors have not been widely studied. Knowing more about it potentially important because clear chondrosarcomas are often misdiagnosed as other benign lesions subsequently treated followed inappropriately. Questions/purposes (1) What the patient- tumor-related characteristics of chondrosarcoma? (2) proportion patients with initially had a misdiagnosis or misleading initial...
We report here a case of periosteal sarcoma in 10-year-old female, along with quantitative values obtained bone single photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate treatment response preoperative chemotherapy. Pretreatment radiograph images the lower leg showed cortical thickening eroded by broad-based soft-tissue mass without involvement underlying cortex, while (CT) revealed small juxtacortical thick calcification and reaction. In...
We here report on 2 cases of monostotic Paget’s disease bone, one in the ilium and other skull, including quantitative values obtained with bone single photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate response bisphosphonate treatment. The parameters determined those findings decreased, maximum standardized uptake value (SUV), peak SUV, mean metabolic volume, total case 1 reduced by 48.8 60.3%, 46.6 58.8%, 24.3 60.5%, 87.0 11.8%, 90.2 55.8%,...
Background: Skeletally immature children with a primary malignant tumor in the distal end of femur are candidates for limb-salvage surgery; however, functional impairment due to subsequent limb-length discrepancy must be considered. Our aim was evaluate long-term clinical outcome limb salvage patients sarcoma who were eleven years old or less, focusing on and complications. Methods: The cases forty retrospectively reviewed multicenter study based responses questionnaire. Twenty-eight had...
Vascular endothelial growth inhibitor (VEGI; also referred to as TNFSF15 or TL1A) is involved in the modulation of vascular homeostasis. VEGI known operate via two receptors: Death receptor‑3 (DR3) and decoy (DcR3). DR3, which thus far only functional receptor for VEGI, contains a death domain induces cell apoptosis. DcR3 secreted soluble protein antagonizes VEGI/DR3 interaction. Overexpression downregulation have been detected number cancers. The aim present study was investigate effects...