A5035875063- Glioma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Galectins and Cancer Biology
- Pulmonary Hypertension Research and Treatments
- Chromatin Remodeling and Cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cardiac tumors and thrombi
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Bone Tumor Diagnosis and Treatments
- Ovarian cancer diagnosis and treatment
- Proteoglycans and glycosaminoglycans research
- Viral Infections and Immunology Research
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- Brain Metastases and Treatment
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
Gifu University
2017-2025
Gifu University Hospital
2021-2022
Institute of Neurobiology
2020
Osaka University
2015
Abstract Oral squamous cell carcinoma ( OSCC ) develops through a multistep carcinogenic process involving field cancerization. The DEK gene is proto‐oncogene with functions in genetic and epigenetic modifications, has oncogenic functions, including cellular proliferation, differentiation, senescence. overexpression associated malignancies; however, the functional roles of are unclear. We demonstrated that ‐expressing cells were significantly increased human dysplasia/carcinoma situ ....
Purpose Upregulation of type I interferon (IFN) signaling has been increasingly detected in inflammatory diseases. Recently, upregulation the IFN signature suggested as a potential biomarker IFN-driven Yet, it remains unclear to what extent is involved pathogenesis undifferentiated This study aimed quantify clinically undiagnosed patients and assess clinical characteristics those with high signature. Methods The was measured patients’ whole blood cells. Clinical biological data were...
To elucidate the magnetic resonance imaging (MRI) characteristics for distinguishing solitary fibrous tumors (SFTs) from desmoid (DTs). A retrospective study of 66 consecutive patients with histopathologically proven SFT (n = 34; 13 males and 21 females; mean age, 52.0 ± 17.1 years) or DT 32; 11 39.0 21.3 was conducted. The two groups were quantitatively compared in terms size, signal intensity ratio (SIR), apparent diffusion coefficient value. For qualitative analysis, tumor location,...
Non-ampullary duodenal adenoma with activation of Wnt/β-catenin signalling is common in familial adenomatous polyposis (FAP) patients, whereas sporadic non-ampullary uncommon. The adenoma-carcinoma sequence similar to colon cancer associated tumors FAP, but not always tumors. We obtained 37 tumors, including 25 adenomas and 12 adenocarcinomas, were from biopsies endoscopic resections. performed immunohistochemistry for β-catenin, the hallmark Wnt activation, aldehyde dehydrogenase 1 (ALDH1),...
Galectin-3 is a β-galactoside-binding lectin which important in cell proliferation and apoptotic regulation. Recently, serum galectin-3 has been shown to have prognostic value as biomarker heart failure. Encephalomyocarditis virus (EMCV) can cause severe myocarditis, congestive failure dilated cardiomyopathy well encephalitis various animals including mice. The pathophysiological role of acute myocarditis following viral infection not fully understood. goal this study determine the cardiac...
Galectin-3 is a beta-galactoside-binding lectin that plays important roles in diverse physiological functions, such as cell proliferation, apoptosis, and mRNA splicing. This protein expressed on inflammatory cells acts local mediator. Recently, galectin-3 has been detected several diseases, chronic liver, heart, kidney diabetes, viral infection, autoimmune neurodegenerative tumors, its role biomarker attracted attention. Alpha-galactosylceramide an artificially synthesized sphingolipid can...
Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type precancerous lesion cholangiocarcinoma is limited. Moreover, reproducible in vivo model lacking, and IPNB pathogenesis remains unclear. Here, we use doxycycline-inducible tetracycline (Tet)-on mice to control fibroblast growth factor 10 (FGF10) expression, which regulates branching tubule formation. FGF10-induced mimics multifocal divergent human phenotypes via FGF10-FGF receptor 2...
The cyclin-dependent kinase inhibitor 2A (CDKN2A)/alternate reading frame (ARF) locus consists of two overlapping tumor suppressor genes, p16INK4a and p14ARF (p19ARF in mice), encoding unrelated proteins alternative frames. Previous reports suggest that alterations independently exhibit differential roles, is more closely associated with a poor prognosis oral cancer. However, the role p16INK4a-specific loss squamous cell carcinogenesis remains unclear. authors assessed chemical carcinogen...
Gliomas typically escape surgical resection and recur due to their "diffuse invasion" phenotype, enabling them infiltrate diffusely into the normal brain parenchyma. Over past 80 years, studies have revealed 2 key features of designated Scherer's secondary structure, include perineuronal satellitosis (PS) perivascular (PVS). However, mechanisms are still unknown.We established a mouse glioma cell line (IG27) by manipulating histone H3K27M mutation, frequently harboring in diffuse intrinsic...
Loss of E-cadherin expression is frequently observed in signet ring carcinoma (SRCC). People with germline mutations CDH1, which encodes E-cadherin, develop diffuse gastric cancer at a higher rate. thus assumed to trigger oncogenic development.To investigate novel therapeutic targets for SRCC, we engineered an E-cadherin-deficient SRCC model vitro using human organoid (hGO) CDH1 knockout (KO).CDH1 KO hGO cells demonstrated distinctive morphological changes similar and high cell motility....
Abstract Purpose This study aimed to compare the radiological tumor (T)-category using multiparametric MRI with pathological T category in patients oral tongue squamous cell carcinoma (OTSCC) and examine which is a better predictor of prognosis. Methods retrospective included 110 consecutive surgically resected primary OTSCC who underwent preoperative contrast-enhanced MRI. categories determined by maximum diameter depth invasion were retrospectively assessed based on specimen The assessment...
Serrated lesions in the colorectum are currently predominantly classified as hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional adenomas (TSAs) according to their morphology. However, histological morphology molecular changes still unclear. We performed immunohistochemistry for Ki67, p16INK4a, WNT5A human HPs (n=22), SSA/Ps (n=41), TSAs (n=19). The distribution of Ki67 p16INK4a positive cells was different from that SSA/Ps. Co-expression P16INK4a infrequent...
Acute funisitis, a granulocyte-related inflammation of the umbilical cord, is associated with chorioamnionitis and perinatal adverse events. However, there no efficient procedure for detecting clinically relevant cord inflammation. The objective this study was to identify such inflammation, based on immunohistochemical assessment vasculitis patterns. Accordingly, 261 cases were retrieved from single medical institute. Using well-established granulocyte marker CD15, we developed five-tier...
Malignant pleural effusion (MPE) can accompany advanced lung adenocarcinoma. Recent studies suggest that MPE could contain a heterogeneous subpopulation of cells with stem-like properties, such as tumorigenicity and self-renewal, indicating they be the source metastasis. Although previous analyzed correlation between cancer stem cell (CSC) marker expression clinical outcomes using tissues, investigations regarding association CSC are limited. We performed immunohistochemistry to examine...
Heparan sulfate (HS) is one of the factors that has been suggested to be associated with angiogenesis and invasion glioblastoma (GBM), an aggressive fast-growing brain tumor. However, it remains unclear how HS endothelial cells involved in its prognosis. Thus, we investigated effect cell on GBM development.We generated cell-specific knockout Ext1, a gene encoding glycosyltransferase essential for synthesis, murine GL261 were orthotopically transplanted. Two weeks after transplantation,...
Poorly differentiated chordoma (PDC) is a rare, aggressive subtype of chordoma. A two-year-old girl presented with cervical pain, limb paralysis and respiratory failure. Magnetic resonance imaging positron emission tomography-computed tomography revealed tumor compressing the pons at clivus osteoblastic metastatic lesions left upper arm right iliac bone. Her tumors shrank substantially after treatment chemotherapy proton beam therapy. Our initial diagnosis was an atypical teratoma/rhabdoid...
Kaposiform lymphangiomatosis (KLA) is a recently characterized systemic lymphatic anomaly. Activation of RAS/MAPK and PI3K/AKT/mTOR pathways may affect KLA pathogenesis, but the cellular basis unclear. Abnormal-spindle endothelial cells that express cell (LEC) markers are characteristic histopathology. This study evaluated patient-derived to establish their morphological biological characteristics.We established lines from primary tissues two patients with examined functional...