A5063617663- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Orthopedic Surgery and Rehabilitation
- Glaucoma and retinal disorders
- Galectins and Cancer Biology
- Ocular Surface and Contact Lens
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alzheimer's disease research and treatments
- Ophthalmology and Eye Disorders
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Knee injuries and reconstruction techniques
- Meningioma and schwannoma management
- 14-3-3 protein interactions
- Acute Ischemic Stroke Management
- Tendon Structure and Treatment
- Macrophage Migration Inhibitory Factor
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Fibroblast Growth Factor Research
- Liver physiology and pathology
- Traumatic Brain Injury and Neurovascular Disturbances
Gifu Prefectural General Medical Center
2024
Gifu University
2017-2021
Gifu University Hospital
2017-2021
Institute of Neurobiology
2020
Kurume University
2012-2019
Japan Community Healthcare Organization
2019
Kurume University Medical Center
2016
Kawasaki Municipal Hospital
2015
Ome Municipal General Hospital
2012
Inouye Eye Hospital
2011
Pathological changes of Alzheimer disease are characterized by cerebral cortical atrophy as a result degeneration and loss neurons. Typical histological lesions include numerous senile plaques composed deposits amyloid beta-protein neurofibrillary tangles consisting predominantly ubiquitin highly phosphorylated tau proteins. Previously, protein kinase I (TPK I) was purified its cDNA cloned. To examine the biological role this enzyme in neurons, we have studied induction activity primary...
According to the amyloid hypothesis for pathogenesis of Alzheimer disease, beta-amyloid peptide (betaA) directly affects neurons, leading neurodegeneration and tau phosphorylation. In rat hippocampal culture, betaA exposure activates protein kinase I/glycogen synthase 3beta (TPKI/GSK-3beta), which phosphorylates into disease-like forms, resulting in neuronal death. To elucidate mechanism betaA-induced death, we searched substrates TPKI/GSK-3beta a two-hybrid system identified pyruvate...
PURPOSE: To evaluate secondary degeneration of the ipsilateral thalamus after cerebral infarction in middle artery (MCA) distribution by using magnetic resonance (MR) imaging. MATERIALS AND METHODS: Thirty patients (17 men, 13 women; aged 30-85 years) with embolic MCA underwent serial MR imaging 2 hours to 12 months a stroke. In 23 30 patients, authors evaluated blood flow single photon emission computed tomography (SPECT). RESULTS: T2-weighted spin-echo images disclosed hyperintense area 14...
Abstract Oral squamous cell carcinoma ( OSCC ) develops through a multistep carcinogenic process involving field cancerization. The DEK gene is proto‐oncogene with functions in genetic and epigenetic modifications, has oncogenic functions, including cellular proliferation, differentiation, senescence. overexpression associated malignancies; however, the functional roles of are unclear. We demonstrated that ‐expressing cells were significantly increased human dysplasia/carcinoma situ ....
Background: after anterior cruciate ligament (ACL) reconstruction, it is necessary to integrate free tendon graft biologically the bone.In present study, verify whether a structure identical normal ligament-bone insertion could be regenerated at tendon-bone interface without bone tunnel, we designed ACL reconstruction model tibial tunnel.Moreover, enhance integration process in this model, marrow-derived mesenchymal stem cells (bMSCs) were transplanted, and histological changes...
Non-ampullary duodenal adenoma with activation of Wnt/β-catenin signalling is common in familial adenomatous polyposis (FAP) patients, whereas sporadic non-ampullary uncommon. The adenoma-carcinoma sequence similar to colon cancer associated tumors FAP, but not always tumors. We obtained 37 tumors, including 25 adenomas and 12 adenocarcinomas, were from biopsies endoscopic resections. performed immunohistochemistry for β-catenin, the hallmark Wnt activation, aldehyde dehydrogenase 1 (ALDH1),...
Galectin-3 is a β-galactoside-binding lectin which important in cell proliferation and apoptotic regulation. Recently, serum galectin-3 has been shown to have prognostic value as biomarker heart failure. Encephalomyocarditis virus (EMCV) can cause severe myocarditis, congestive failure dilated cardiomyopathy well encephalitis various animals including mice. The pathophysiological role of acute myocarditis following viral infection not fully understood. goal this study determine the cardiac...
The purpose of this study was to evaluate chronological changes in the collagen-type composition at tendon-bone interface during healing and clarify continuity between Sharpey-like fibres inner tendon.Male white rabbits were used create an extra-articular bone-tendon graft model by grafting extensor digitorum longus into a bone tunnel. Three killed two, four, eight, 12 26 weeks post-operatively. Elastica van Gieson staining colour 5 µm coronal sections, which examined under optical polarised...
To evaluate the degeneration of ipsilateral substantia nigra after striatal infarction by using magnetic resonance (MR) imaging.Twenty-five adult patients with embolic cerebral middle artery distribution underwent MR imaging 0-4, 5-9, 12-15, and 27-29 days stroke. Sixteen them also follow-up 2-12 months stroke.Ten had an infarct in striatum or without a cortical (striatal group); other 15 cortex (cortical group). In all 10 infarction, hyperintense spot appeared on T2-weighted fast spin-echo...
Galectin-3 is a beta-galactoside-binding lectin that plays important roles in diverse physiological functions, such as cell proliferation, apoptosis, and mRNA splicing. This protein expressed on inflammatory cells acts local mediator. Recently, galectin-3 has been detected several diseases, chronic liver, heart, kidney diabetes, viral infection, autoimmune neurodegenerative tumors, its role biomarker attracted attention. Alpha-galactosylceramide an artificially synthesized sphingolipid can...
Treatment of anterior choroidal artery (AChA) aneurysms with endovascular coiling or surgical clipping may increase the risk ischemic complications owing to critical territory supplied by AChA. We analyzed results and for AChA performed in a single institution, as well role indocyanine green-videoangiography (ICG-VAG) motor-evoked potential (MEP).We 50 patients (51 aneurysms; 21 men, 29 women; mean age: 58 years) including 25 subarachnoid hemorrhage treated between April 1990 October 2013....
Evidence regarding intraductal papillary neoplasm of the bile duct (IPNB) as a type precancerous lesion cholangiocarcinoma is limited. Moreover, reproducible in vivo model lacking, and IPNB pathogenesis remains unclear. Here, we use doxycycline-inducible tetracycline (Tet)-on mice to control fibroblast growth factor 10 (FGF10) expression, which regulates branching tubule formation. FGF10-induced mimics multifocal divergent human phenotypes via FGF10-FGF receptor 2...
Purpose: To prospectively investigate adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. We also examined patient attitudes via a questionnaire. Methods: Fifty-two hypertension were enrolled. Iridial, eyelid, and eyelash photographs taken before at 6 months after treatment. Increase eyelid pigmentation, iridial growth bristle, vellus hair of the lid was assessed from photographs. Questionnaires completed by provided insight into their subjective...
Ischemia-reperfusion injuries produce reactive oxygen species that promote the peroxide lipid oxidation process resulting in production of an endogenic peroxide, 4-hydroxy-trans-2-nonenal (4-HNE), a highly cytotoxic aldehyde induces cell death. We synthesized novel 4-HNE scavenger - carnosine-hydrazide derivative, l-carnosine hydrazide (CNN) and examined its neuroprotective effect model transient ischemia. PC-12 cells were pre-incubated with various doses (0-50 mmol/L) CNN for 30 min,...
Some patients with moyamoya disease (MMD) show broad infarction moderate internal carotid artery (ICA) stenosis, whereas others complete ICA occlusion no infarction. This suggests that other factors contribute to the occurrence of Contributing predictive cerebral infarcts must be identified for prevention and consequent neurological deficits.We examined data from 93 confirmed MMD presence (n = 72), transient ischemic attack (TIA, n 41), asymptomatic presentation 51), or hemorrhage 22) in 186...
The cyclin-dependent kinase inhibitor 2A (CDKN2A)/alternate reading frame (ARF) locus consists of two overlapping tumor suppressor genes, p16INK4a and p14ARF (p19ARF in mice), encoding unrelated proteins alternative frames. Previous reports suggest that alterations independently exhibit differential roles, is more closely associated with a poor prognosis oral cancer. However, the role p16INK4a-specific loss squamous cell carcinogenesis remains unclear. authors assessed chemical carcinogen...
The purpose of this prospective study was to investigate the intraocular pressure (IOP)-lowering effect and safety latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops, now available in Japan.Thirty-one patients diagnosed with primary open-angle glaucoma who had an insufficient (IOP) decrease eyedrop monotherapy were enrolled. eyedrops discontinued, administration 0.005%/timolol initiated without any washout period. IOP compared before at months 1, 3, 6 after switch....
Prognosis after extracranial-intracranial (EC-IC) bypass surgery has only been studied for a few years and the benefits of this procedure are still controversial. In single-center retrospective study, we examined long-term prognosis patients who underwent EC-IC surgery. Subjects were with symptomatic internal carotid artery or intracranial lesion occlusive disease between 1991 2003. Of these, was in 57 (39 male, 18 female; mean age, 61.8 years) showed good surgical outcomes 30 days surgery,...
Abstract In selected patients with metastatic renal cell carcinoma, metastasectomy can achieve prolonged survival. Herein we report a patient concomitant pancreatic and duodenal metastases occurring 12 years after total right nephrectomy for carcinoma. The were successfully treated by pancreas-sparing duodenectomy distal pancreatectomy. A 66-year-old man was referred to our hospital chief complaint of upper abdominal pain. He had undergone laparoscopic carcinoma before. Enhanced computed...