A5011462047- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Endometrial and Cervical Cancer Treatments
- Oral Health Pathology and Treatment
- Cancer Treatment and Pharmacology
- Burn Injury Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Urologic and reproductive health conditions
- Lymphoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Lipid metabolism and disorders
- Spine and Intervertebral Disc Pathology
- Nutrition and Health in Aging
- Cell Adhesion Molecules Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peroxisome Proliferator-Activated Receptors
- HIV/AIDS oral health manifestations
- Cancer Cells and Metastasis
- BRCA gene mutations in cancer
- Advanced Neuroimaging Techniques and Applications
Kowa (Japan)
2024-2025
Tokyo National Hospital
2022-2025
University of Washington
2022-2025
National Cancer Center
2022-2024
National Cancer Center Hospital East
2022-2024
Brown University
2020-2024
Kitasato University
2024
University of Shizuoka
2022
Seattle University
2022
Kameda Medical Center
2019-2020
Long-term safety and efficacy of pemafibrate once-daily extended-release (XR) tablets, taken in morning or evening, were evaluated dyslipidemic patients with high triglycerides (TG). In this multicenter, randomized, open-label, parallel-group, phase 3 long-term study, TG randomly assigned to evening administration XR for 52 weeks. The dose was started at 0.2 mg/day increased 0.4 having fasting serum ≥ 150mg/dL during treatment. primary endpoint percent change TG. study enrolled 121 patients,...
To elucidate the mechanisms of severe itch in atopic dermatitis, we investigated role leukotriene B(4) , a potent mediator, spontaneous itch-related behaviour NC mice with dermatitis-like skin lesions. Topical application BLT receptor antagonist ONO-4057 inhibited behaviour. The concentration was significantly increased lesional skin. expression levels 5-lipoxygenase were also elevated skin, yet present throughout epidermis both healthy and These results suggest for chronic...
Aims: Pemafibrate, a selective peroxisome proliferator-activated receptor α modulator that lowers serum triglyceride levels and increases high-density lipoprotein cholesterol levels, is approved for treating dyslipidemia as twice-daily immediate-release (IR) tablets. A once-daily extended-release (XR) tablet has also been developed. We aimed to confirm the non-inferiority of XR (0.2 or 0.4 mg/day; once daily) IR twice in lowering patients with hypertriglyceridemia.
Abstract Background Helicobacter pylori ( H. ) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two with gene expression profiles during gastric carcinogenesis remain unclear. In the present study, we investigated global associated prognosis human using a mouse model. Methods To find candidate genes involved carcinogenesis, firstly constructed carcinogen-induced tumor model combined high-salt diet. C57BL/6J...
Triple-negative breast cancer (TNBC) is negative for hormone receptors and human epidermal growth factor receptor 2 (HER2). In stage I TNBC, adjuvant therapy or follow-up are performed according to risk factors, but clinical trial data scarce. recent years, it has been reported that HER2-low cases (1+/2+ in situ hybridization negative) have different prognoses than HER2-0 cases. However, the of recurrence factors this population TNBC not yet investigated.Herein, out 174 patients with who...
Abstract Introduction Burns can cause serious physical injury and psychosocial distress. Extremes of body weight also result in impaired recovery emotional However, the impact BMI on long-term self-reported outcomes is not well understood. We aimed to compare long-term, functional among adult burn survivors who were obese, normal weight, underweight at discharge. Methods Adult participating a national longitudinal, multicenter patient-reported database between 2015-2023 included....
Abstract Introduction Long-term recovery among burn survivors is multifactorial, including characteristics such as total body surface area burned and mechanism of injury. Various preinjury factors a history depression anxiety are also associated with impaired long-term recovery. One social factor that has not been well studied pre-injury employment status on patient-reported outcomes post-injury. Understanding the longitudinal health impact critical to improving public In this study, we...
Abstract Introduction Stigma is defined as when someone treated negatively or devalued due to a particular characteristic attribute. People with physical appearances that differ from the expected, such individuals burn injury, are at risk for stigmatization. This may influence quality of life and can lead social isolation. Therefore, this study aims examine stigma its predictors in population. Methods Adult survivors multicenter longitudinal database 2015-24 were examined. The primary...
Abstract Background: Ovarian clear cell carcinoma (OCCC) is a rare subtype of ovarian cancer, with higher incidence in East Asia compared to Western countries and tendency affect younger individuals. OCCC has poor prognosis due its low sensitivity chemotherapy, presenting significant unmet medical need. However, therapeutic development been limited rarity. Recently, advancements antibody-drug conjugates (ADCs) targeting Trophoblastic cell-surface marker (TROP2) have shown promise, but the...
Abstract Prognostic value of hematologic indices and their association with the tumor microenvironment (TME) remain unclear in advanced soft tissue sarcoma (STS). We aimed to evaluate prognostic correlation TME status STS treated first-line doxorubicin (DXR) therapy. Clinical data three hematological indices, including lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte were collected from 149 patients STS. The was pathologically examined by CD3, CD68,...
Introduction: Next-generation sequencing (NGS) is commonly used in clinical practice to decide treatment based on genomic information. This study was performed optimize the proportion of actionable gene profiling and genetic alterations breast cancer at one centers Japan. Methods: Patients with who reported NGS results Japan from August 2019 December 2023 were retrospectively investigated by reviewing their electronic medical records. examined using OncoGuideTM NCC Oncopanel System,...
ABSTRACT Background Adenoid cystic carcinoma (ACC) is the second most common and treatment‐resistant salivary gland (SGC). Although platinum‐based therapies are effective, efficacy of eribulin, a microtubule inhibitor with an 18% response rate in Phase II trial involving recurrent/metastatic SGC, patients advanced ACC after platinum therapy remains unclear. Methods We retrospectively analyzed 19 unresectable/metastatic treated between December 2015 January 2023 at National Cancer Center...
Recently, we reported that a pemafibrate extended-release (XR) formulation lowered low-density lipoprotein cholesterol (LDL-C) and synthesis absorption markers in phase 2 clinical pharmacology study. Here describe our post-hoc analysis of study, discuss the mechanism by which lowers LDL-C, suggest patients may respond favorably to treatment. In with hypertriglyceridemia received treatment immediate-release (IR) 0.2 mg/day or XR 0.4 0.8 mg/day. This subgroup examined percentage change...
Epicardial adipose tissue (EAT) is known to affect atherosclerosis and coronary artery disease (CAD) pathogenesis, persistently releasing pro-inflammatory adipokines that the myocardium arteries. Angiopoietin-like 4 (ANGPTL4) a protein secreted from plays critical role in progression of atherosclerosis. Here, expression ANGPTL4 EAT was investigated CAD subjects. Thirty-four consecutive patients (13 with significant CAD; 21 without CAD) undergoing elective open-heart surgery were recruited....
<h3>BACKGROUND AND PURPOSE:</h3> Preoperative identification of plaque vulnerability may allow improved risk stratification for patients considered carotid endarterectomy. The present study aimed to determine which imaging technique, cardiac-gated black-blood fast spin-echo, magnetization-prepared rapid acquisition gradient echo, source image 3D time-of-flight MR angiography, or noncardiac-gated most accurately predicts development microembolic signals during exposure arteries in...
The present preliminary study aimed to investigate the association between oral human papillomavirus type 16 (HPV16) DNA prevalence and periodontal inflammation in older women. HPV16 infection health status has not been fully elucidated Japanese investigated women aged ≥60 years who visited Hiroshima University Hospital. excluded subjects with clinical factors affecting HPV infection, such as current smoking, cancer pre‑malignant lesions, immunodeficiency. Finally, 46 female patients (mean...
Abstract Purpose Stromal tumor-infiltrating lymphocytes (TILs) are independent prognostic factors in systemically untreated early-stage triple-negative breast cancer (TNBC). Other immune biomarkers including CD8, CD20, programmed cell death-ligand 1 (PD-L1), and tertiary lymphoid structures (TLS) also reported to be associated with prognosis. However, whether combining other TILs would allow for further stratification is unknown. Methods We retrospectively analyzed 125 patients TNBC not...
Trabectedin is used as a treatment for advanced-stage soft tissue sarcomas (STSs), particularly liposarcoma and leiomyosarcoma. Aside from its direct effect on tumor cells, trabectedin can affect the immune system in microenvironment. This study aimed to evaluate whether inflammatory biomarkers predict efficacy STSs.
Abstract Introduction: Antibody-drug conjugates (ADCs) targeting trophoblast cell surface antigen 2 (TROP2), such as sacituzumab-govitecan and datopotamab-deruxtecan, have recently been developed. A preclinical study has reported the efficacy of anti-human epidermal growth factor receptor (HER2) TROP2 bispecific ADCs in treating HER2 co-expressing tumors, including HER2-low tumors various solid (Chengzhang Shang et al: AACR 2023). In this study, we aimed to evaluate expression by...