A5103005815- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Estrogen and related hormone effects
- Cancer and Skin Lesions
- Electron Spin Resonance Studies
- Cancer survivorship and care
- Cancer-related molecular mechanisms research
- Bone health and treatments
- PARP inhibition in cancer therapy
- RNA modifications and cancer
- Lymphatic System and Diseases
- Medical Imaging Techniques and Applications
- Single-cell and spatial transcriptomics
- BRCA gene mutations in cancer
- Brain Metastases and Treatment
- Multiple and Secondary Primary Cancers
Tokyo National Hospital
2016-2025
National Cancer Center Hospital East
2021-2025
Japan Breast Cancer Research Group
2023
National Cancer Centre Japan
2019-2020
Tokyo Dental College Ichikawa General Hospital
2011-2012
Kansai Medical University
2009
Saitama Medical University
2009
Keio University
2005
Phorbol 12-myristate 13-acetate (PMA) was used to examine the role of insulin receptor phosphorylation in regulation internalization vascular endothelial cells. Association 125I-insulin rat capillary and bovine aortic cells preincubated with PMA increased by 80 64% over control, respectively. The increase due enhanced as opposed an effect on surface-bound hormone. had no significant degradation or release internalized from Internalization 125I-labeled determined resistance labeled...
Background A strategy for maintaining and/or improving cardiorespiratory fitness (CRF) in the growing population of cancer survivors is major clinical importance, especially COVID-19 era. The effect unsupervised high-intensity interval training (HIIT) on increasing CRF breast unknown. Purpose purpose this study was to determine whether newly developed habit-B programme, which involves home-based smartphone-supported HIIT using body weight exercises, improves early-stage survivors. Methods...
Abstract Ductal carcinoma in situ (DCIS) is a precursor to invasive breast cancer. The frequency of DCIS increasing because routine mammography; however, the biological features and intratumoral heterogeneity remain obscure. To address this deficiency, we performed single-cell transcriptomic profiling ductal (IDC). was found be composed several transcriptionally distinct subpopulations cancer cells with specific functions. Several transcripts, including long noncoding RNAs, were highly...
This prospective, multicenter, single-arm Phase II trial investigates the feasibility and safety of tailored axillary surgery (TAS) in patients with clinically node-positive breast cancer who are undergoing upfront surgery. The aims to establish criteria for safely omitting lymph node dissection (ALND) these cases, potentially shifting management by minimizing surgical complications preserving patients' quality life (QOL). study includes were diagnosed invasive cancer, particularly those...
<title>Abstract</title> Background In recent years, multigene assays have become indispensable tools for predicting the recurrence risk of estrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-negative early-stage breast cancer and guiding adjuvant chemotherapy decisions. Curebest™ 95GC Breast (95GC), developed in 2011 as a domestically produced assay postoperative prediction, has been commercially available since 2013. Since 2021, five validation studies evaluating...
Abstract Background For breast cancer patients, postoperative lymphedema and upper limb movement disorders are serious complications that absolutely reduce their quality of life (QOL). To evaluate this complication, we used “Quick Dash” or “FACT-B”, which can assess a patient's physical, social, emotional, functional health status. surgery-related dysfunction correctly, “FACT-B + 4” was created by adding four questions about “arm swelling'' “tenderness”. We have translated it into Japanese...
The impact of progesterone receptor (PR) status on the prognosis breast cancer after isolated locoregional recurrence (ILRR) remains unclear. This study evaluated clinicopathologic factors, including PR ILRR, distant metastasis (DM) ILRR.We retrospectively identified 306 patients with ILRR diagnosed at National Cancer Center Hospital between 1993 and 2021 from database. Cox proportional hazards analysis was performed to examine factors associated DM ILRR. We developed a risk prediction model...
Abstract Purpose Stromal tumor-infiltrating lymphocytes (TILs) are independent prognostic factors in systemically untreated early-stage triple-negative breast cancer (TNBC). Other immune biomarkers including CD8, CD20, programmed cell death-ligand 1 (PD-L1), and tertiary lymphoid structures (TLS) also reported to be associated with prognosis. However, whether combining other TILs would allow for further stratification is unknown. Methods We retrospectively analyzed 125 patients TNBC not...
The efficacy and safety of olaparib compared with placebo in the subset patients from Japan phase 3 OlympiA trial (NCT02032823) are reported here contextualized reference to global population.Patients germline BRCA1 and/or BRCA2 pathogenic variants HER2-negative, high-risk early breast cancer who had received neoadjuvant or adjuvant chemotherapy completed local treatment were eligible. Patients randomized 1:1 receive for 1 year.invasive disease-free survival (IDFS). Secondary endpoints:...
Due to the increase in number of early-stage breast cancer patients, there is growing interest minimally invasive local therapies for cancer. Radiofrequency ablation (RFA) therapy one most promising treatments. The Ablation Therapy Early Breast Cancer as Local (RAFAELO) study, a multicenter collaborative study that aims validate efficacy and safety RFA standardize its use cancer, was conducted under Advanced Medical Care B system 2013. This enrolled expected patients November 2017; moreover,...
578 Background: The RAFAELO study is designed to evaluate the safety and efficacy of breast radiofrequency ablation, enabling women between 20 79 years age with small cancers benefit from a nonsurgical treatment avoid associated surgical risks. Methods: prospective, multi-center, single-arm, confirmatory trial including unifocal, MRI ultrasound-visible invasive ductal carcinoma or in situ size 1.5 cm smaller diagnosed by preoperative core-needle biopsy, classified as any grade, hormone...
Background The one‐step nucleic acid amplification (OSNA) assay can quantify the cytokeratin 19 messenger RNA copy number as a proxy for sentinel lymph node (SN) metastasis in breast cancer. A large‐scale, multicenter cohort study was performed to determine prognostic value of SN tumor burden based on molecular readout and establish model prediction early systemic recurrence patients using OSNA assay. Methods biopsies from 4757 with cancer were analyzed randomly assigned training or...
The occurrence of iatrogenic tumor cell seeding (seeding) in needle tract scars formed by core biopsy (CNB) or vacuum-assisted (VAB) is well known. Some risk factors for have been reported, but the clinicopathological and its prognosis not fully investigated. We evaluated clinical features seeding.We included 4405 patients who had undergone surgery (lumpectomy mastectomy) with a diagnosis breast cancer preoperative CNB VAB at our hospital between January 2012 February 2021. Data confirmed...
Prospective randomized trials have demonstrated that postmastectomy radiotherapy (PMRT) improves not only locoregional recurrence-free survival, but also overall survival for node-positive breast cancer patients. Subset analyses in previous shown improvement of with PMRT is always patients 1-3 positive nodes. Indications are still marginal pathological invasion 5 cm diameter and The aim this study was to clarify poor prognostic factors size Participants comprised 428 T1-2 tumor axillary...
Spontaneous regression of a malignant tumor is defined as "the partial or complete disappearance in the absence any treatment." Herein, we report case occult breast cancer with axillary lymph node metastasis that showed spontaneous based on histopathological findings.A 67-year-old woman presented left armpit pain and lump. Previous examination by another doctor revealed swelling node, but it was difficult to identify primary lesion. Needle biopsy tissue extensive necrosis histological...
Chemotherapy and radiotherapy were postulated to induce an inflamed tumour microenvironment. We aimed evaluate the effects of adjuvant chemotherapy/radiotherapy on tumour-infiltrating lymphocytes (TILs) programmed death-ligand 1 (PD-L1) expression in metastatic breast cancer.We identified paired primary tumours 85 patients with cancer. Stromal TILs assessed according international guidelines. PD-L1 was evaluated using VENTANA SP142 assay.TILs significantly lower than (12.2 vs. 8.3%, p =...
/Objective: To evaluate the usefulness of combining radioisotopes (RI) and indocyanine green (ICG) investigate discordances in sentinel lymph node (SN) reactivity using each tracer cN0 breast cancer patients.In total, 338 primary patients who underwent SN biopsy with RI ICG axillary (ALN) dissection were included. positivity RI, ICG, a combination was denoted as SN(RI), SN(ICG), SN(RI+ICG), respectively. We retrospectively estimated metastatic detection rates, method's discordance rate,...
Abstract Adjuvant therapy for patients with hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative, node-positive, early breast cancer (EBC) remains challenging. The prognostic significance of HER2-low positivity in these is not fully understood. In our retrospective study, we analyzed 647 HR-positive, HER2-negative, node-positive EBC, stratifying them into three cohorts based on axillary lymph node involvement, tumor size, and characteristics. Cohort 1 included...
It has been determined that axillary lymph node dissection after the detection of limited metastasis does not improve prognosis patients with breast cancer. Thus, a need exists for less-invasive surgery. However, it remains unclear whether predictive model based on preoperative data would be sufficient to accurately predict probability pN2-N3 (> 3 metastases). We sought develop an easy-to-use scoring system distinguish between pN0-N1 (0-3 metastases) and using only validate its...
Clinical response predictions through image examinations after neoadjuvant chemotherapy (NAC) for breast cancer is important. The present study aimed to evaluate the utility of a novel imaging modality, positron-emission tomography/magnetic resonance (PET/MRI), in predicting pathological complete (pCR) NAC patients with early cancer. A total 74 underwent PET/MRI, mammography (MG), including tomosynthesis, and ultrasound (US) NAC. was predicted using each modality these outcomes were compared...