A5067561532- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Axon Guidance and Neuronal Signaling
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Lesions and Carcinomas
Gifu University Hospital
2019-2025
Gifu University
2015-2024
National Cancer Center Hospital East
2019-2024
Akita Prefectural University
2023
National Hospital Organization
2019
Dokkyo Medical University
2019
Kohnan Hospital
2019
Kindai University
2019
Shikoku Cancer Center
2019
Chiba Cancer Center
2019
Abstract Tumor associated macrophages (TAMs) play a critical role in biology of various cancers, including breast cancer. In the current study, we defined “M1” macrophage and “M1”/“M2” ratio by transcriptomic signatures using xCell. We investigated association between high level or tumor immune microenvironment analyzing transcriptome publicly available cohorts, TCGA METABRIC. found that tumors were not with prolonged survival compared low tumors, response to neoadjuvant chemotherapy....
To analyze the clinical value of reverse transcriptase-polymerase chain reaction (RT-PCR) recognition mRNA coding for carcinoembryonic antigen (CEA) and cytokeratin 20 in blood obtained from patients with colorectal carcinoma.RT-PCR has been applied to identify very small numbers tumor cells. Molecular detection is thought provide useful information management perioperative prophylaxis cell implantation or postoperative adjuvant therapy regimens.From 52 cancer, peripheral specimens were...
Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) synergistically increased the effectiveness of antiprogrammed cell death protein-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibodies in preclinical studies. Methods This non-randomized, multicohort, phase II study evaluated efficacy safety anti-PD-1 antibody nivolumab 240 mg administered every...
Maintenance of healthy mitochondria prevents aging, cancer, and a variety degenerative diseases that are due to the result defective mitochondrial quality control (MQC). Recently, we discovered novel mechanism for MQC, in which Mieap induces intramitochondrial lysosome-like organella plays critical role elimination oxidized proteins (designated MALM Mieap-induced accumulation organelles within mitochondria). However, large part mechanisms MQC remains unknown. Here, report additional...
The metabolism in tumor cells shifts from oxidative phosphorylation to glycolysis even an aerobic environment. This phenomenon is known as the Warburg effect. effect regulated mainly by polypyrimidine tract‐binding protein 1 ( PTBP ), which a splicer of m RNA for rate‐limiting enzymes glycolysis, pyruvate kinase muscle and 2 PKM 2). In present study, we demonstrated that miR‐133b reduced expression at translational level levels were significantly downregulated gastric cancer clinical samples...
The accumulation of unhealthy mitochondria results in mitochondrial dysfunction, which has been implicated aging, cancer, and a variety degenerative diseases. However, the mechanism by quality is regulated remains unclear. Here, we show that Mieap, novel p53-inducible protein, induces intramitochondrial lysosome-like organella plays critical role control. Mieap expression directly p53 frequently lost human cancer as result DNA methylation. dramatically lysosomal proteins within acidic...
// Kohei Taniguchi 1, 2 , Miku Sakai 1 Nobuhiko Sugito Minami Kumazaki Haruka Shinohara Nami Yamada Tatsushi Nakayama Hiroshi Ueda Yoshihito Nakagawa 3 Yuko Ito 4 Manabu Futamura 5 Bunji Uno Yoshinori Otsuki Kazuhiro Yoshida Kazuhisa Uchiyama Yukihiro Akao United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 501-1193, Japan Department General Gastroenterological Surgery, Osaka College, Takatsuki, 569-8686, Gastroenterology, Fujita Health Medicine,...
Cancer-associated adipocytes are known to cause inflammation, leading cancer progression and metastasis. The clinicopathological transcriptomic data from 2256 patients with breast were obtained based on three cohorts: Cancer Genome Atlas (TCGA), GSE25066, a study by Yau et al. For the current study, we defined adipocyte, which is calculated utilizing computational algorithm, xCell, as “intratumoral adipocyte”. These intratumoral appropriately reflected mature in bulk tumor. amount of...
Members of the recently identified family Homo sapiens Aurora/Ipl1‐related kinases (HsAIRKs), homologous to chromosome segregation kinases, fly Aurora and yeast Ipl1 , are highly expressed during M phase, have been suggested regulate centrosome function, segregation, cytokinesis. In present study, immunohistochemical analyses were performed HsAIRK1 HsAIRK3 expression in 78 primary colorectal cancers 36 adenomas as well 15 normal specimens. colon mucosa, some crypt cells showed weak positive...
Background and Objectives: Lymph node metastasis is known as a significant predictor of prognosis in colorectal cancer patients. Recently, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detecting micrometastasis. To assess the risk recurrence accurately determine spread tumor cells, we examined lymph micrometastases series Methods We 202 nodes obtained from 13 patients who underwent curative operation were histologically diagnosed be node-negative, using RT-PCR...
Abstract Although the regulation of tumor angiogenesis is believed to be one core functions p53, mechanism still remains elucidated. Here, we report that semaphorin 3F (SEMA3F), an axon guidance molecule, involved in p53-regulated antiangiogenesis. The expression level SEMA3F mRNA was increased by both exogenous and endogenous p53. Chromatin immunoprecipitation assay indicated a potent p53-binding sequence intron 1 interacts with p53 it has p53-responsive transcriptional activity....
Abstract The Warburg effect is a well-known feature of cancer cells. However, its' functional significance hasn't been elucidated yet. Pyruvate kinase muscle (PKM), which rate-limiting glycolytic enzyme, has 2 isoforms, PKM1 and PKM2. It reported that PKM2 tumor-specific isoform promotes the effect. Also, it thought tumor cells switch their PKM from to during development. Here, we showed this switching machinery was induced only in limited cases, based on expression normal tissues...
microRNA-143 (miR-143) is a well-known tumor suppressive microRNA that exhibits anti-tumoral function by targeting KRAS signaling pathways in various malignancies. We hypothesized miR-143 suppresses breast cancer progression and its effector molecules. further high expression of associated with favorable immune microenvironment estrogen receptor (ER)-positive patients which result improved survival. Two major publicly available cohorts; The Cancer Genome Atlas (TCGA) Molecular Taxonomy...
Most breast cancer (BC) patients succumb to metastatic disease. MiR-34a is a well-known tumor suppressive microRNA which exerts its anti-cancer functions by playing role in p53, apoptosis induction, and epithelial-mesenchymal transition (EMT) suppression. Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) The Genome Atlas (TCGA) cohorts were used test our hypothesis that miR-34a high BCs translate less aggressive biology better survival large cohorts. There was no...
High infiltration of Th2 is linked to breast cancer progression and metastasis through the induction cytokine release T-cell anergy. The estrogen receptor (ER)-positive subtype, which accounts for 70% cancer, known respond less neoadjuvant chemotherapy (NAC) due its low potential proliferation. We hypothesized that high tumors are highly proliferative, thus more likely NAC in ER-positive cancer.We obtained clinicopathological data overall survival information on 1,069 patients from Cancer...
Abstract Background Proton pump inhibitors (PPIs) reduce the bioavailability of several anticancer drugs. The impact PPIs co-administered with cyclin-dependent kinase 4 and 6 is controversial. We aimed to clarify whether concomitant use impacts palbociclib abemaciclib effectiveness in breast cancer treatment. Patients Methods This multicenter, retrospective, observational study, conducted across medical institutions Japan, consecutively included patients endocrine-resistant metastatic...
Recent studies unraveled that AT-rich interactive domain-containing protein 1A (ARID1A), a subunit of the mammary SWI/SNF chromatin remodeling complex, acts as tumor suppressor in various cancers. In this study, we first evaluated ARID1A expression by immunohistochemistry invasive breast cancer tissue specimens and assessed correlation with prognosis patients cancer. Non-tumorous duct epithelial cells exhibited strong nuclear staining, whereas different degrees loss immunoreactivity were...
BackgroundPreclinical models revealed potential synergistic effects of programmed cell death-1 inhibitors and anti-vascular endothelial growth factor (VEGF) antibodies. Therefore, we investigated the use nivolumab, bevacizumab, paclitaxel triple therapy for metastatic breast cancer.MethodsThis phase 2, multicentre, single-arm study (NEWBEAT) safety efficacy first-line paclitaxel, bevacizumab in patients with human epidermal receptor 2-negative cancer, regardless death-ligand 1 expression....