A5072696115- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Ecology and Vegetation Dynamics Studies
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Pain Mechanisms and Treatments
- Plant Stress Responses and Tolerance
- Veterinary Oncology Research
- Light effects on plants
- Sphingolipid Metabolism and Signaling
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Cellular Mechanics and Interactions
- Wildlife Ecology and Conservation
- Ion Channels and Receptors
- Veterinary Orthopedics and Neurology
- Forest Ecology and Biodiversity Studies
- Hydrology and Sediment Transport Processes
- Wood Treatment and Properties
- Streptococcal Infections and Treatments
- Insect Pheromone Research and Control
- Pharmacovigilance and Adverse Drug Reactions
- Plasma Applications and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Advanced Breast Cancer Therapies
Kagoshima University Hospital
2025
Kagoshima University
2024-2025
Tohoku University
2018-2024
Keio University
2013-2024
Shinshu University
2006-2022
Hokkaido University
1985-2020
Daicel (Japan)
2019-2020
Otsu Municipal Hospital
2016
Asahi Kasei (Japan)
2014
Niigata University of Pharmacy and Medical and Life Sciences
2012
The light-harvesting chlorophyll-binding (LHC) proteins are major constituents of eukaryotic photosynthetic machinery. In plants, six different groups proteins, LHC-like share a conserved motif with LHC. Although the evolution LHC and is proposed to be key for diversification modern eukaryotes, our knowledge functions still limited. this study, we aimed understand specifically function one type LIL3 by analyzing Arabidopsis mutants lacking them. genome contains two gene copies LIL3, LIL3:1...
The cellular functions of two Arabidopsis (Arabidopsis thaliana) one-helix proteins, OHP1 and OHP2 (also named LIGHT-HARVESTING-LIKE2 [LIL2] LIL6, respectively, because they have sequence similarity to light-harvesting chlorophyll a/b-binding proteins), remain unclear. Tagged null mutants (ohp1 ohp2) showed stunted growth with pale-green leaves on agar plates, these were unable grow soil. Leaf fluorescence the composition thylakoid membrane proteins revealed that ohp1 deletion substantially...
Abstract Improving geothermal systems through hydraulic stimulation to create highly permeable fractured rocks can induce seismicity. Therefore, the technique must be applied at a moderate intensity; this has led concerns of insufficient permeability enhancement. Adding chemical mitigate these issues, but traditional methods using strong mineral acids have challenges in terms achieving dissolution over long distances and variable fluid chemistry. Here, we demonstrate novel method for...
Abstract Background Proton pump inhibitors (PPIs) reduce the bioavailability of several anticancer drugs. The impact PPIs co-administered with cyclin-dependent kinase 4 and 6 is controversial. We aimed to clarify whether concomitant use impacts palbociclib abemaciclib effectiveness in breast cancer treatment. Patients Methods This multicenter, retrospective, observational study, conducted across medical institutions Japan, consecutively included patients endocrine-resistant metastatic...
The light-harvesting complex (LHC) constitutes the major antenna of photosynthetic eukaryotes. LHC contains a characteristic sequence motif, termed consisting 25–30 mostly hydrophobic amino acids. This motif is shared by number transmembrane proteins from oxygenic photoautotrophs that are light-harvesting-like (LIL) proteins. To gain insights into functions LIL and their motifs, we functionally characterized plant protein, LIL3. protein has been shown previously to stabilize geranylgeranyl...
Abstract The accumulation of amyloid-β protein (Aβ) in brain is linked to the early pathogenesis Alzheimer’s disease (AD). We previously reported that neuron-derived exosomes promote Aβ clearance brains amyloid precursor transgenic mice and exosome production modulated by ceramide metabolism. Here, we demonstrate plant ceramides derived from Amorphophallus konjac , as well animal-derived ceramides, enhanced extracellular vesicles (EVs) neuronal cultures. Oral administration glucosylceramide...
This study sought to create a simple method for screening and detecting oral bacteria associated with periodontal disease as well identify the bacterial species that had strongest correlation severity in dogs. Fifty-two dogs from Kagoshima University Veterinary Teaching Hospital were included. The status, which included gingival recession, root surface exposure, redness, was determined through visual examination. Oral swab samples taken each dog's margin or tooth cervix using sterile cotton...
Plant roots exert hydrotropism in response to moisture gradients avoid drought stress. The regulatory mechanism underlying involves novel regulators such as MIZ1 and GNOM/MIZ2 well abscisic acid (ABA), reactive oxygen species (ROS), Ca2+ signaling. ABA, ROS, signaling are also involved plant responses Although the of gradient perception remains largely unknown, sensory apparatus has been reported reside root elongation zone rather than cap. In Arabidopsis roots, is mediated by action ABA...
Lymphadenomegaly is well described in dogs with neoplastic diseases but can also reflect inflammation. However, its role assessments of inflammation little reported the veterinary literature. Lymph nodes are most easily assessed superficially through palpation, computed tomography (CT) enables evaluation deep lymph nodes. Accordingly, we investigated associations between maximal node diameter and plasma concentrations C-reactive protein (CRP) white blood cell (WBC) count, as inflammatory...
Ceramides, a type of sphingolipid, are cell membrane components and lipid mediators that modulate variety functions. In plants, ceramides mostly present in glucosylated glucosylceramide (GlcCer) form. We previously showed oral administration konjac-derived GlcCer to mouse model Alzheimer's disease reduced brain amyloid-β amyloid plaques. Dietary plant compounds absorbed as ceramides, but it is unclear whether they can cross the blood-brain barrier (BBB). Herein, we evaluated BBB permeability...
A highly potent repellent, sideroxylonal A, was isolated from the benzene extract of leaves Eucalyptus grandis. An attaching attractant identified as 16, 18-tritriacontandione leaf wax E. globulus. Grandinol and analogues were tested for repellent activity in order to establish structure relationships.
Hepatocellular adenoma (HCA) and hepatocellular carcinoma (HCC) can be difficult to differentiate but must diagnosed correctly as treatment prognosis for these tumors differ markedly. Relevant diagnostic biomarkers are thus needed, those identified in dogs may have utility human medicine because of the similarities between canine HCA HCC. A tRNA-derived fragment (tRF), tRNA-Val, is a promising potential biomarker mammary gland has not previously been investigated hepatic tumors. Accordingly,...
Effects of relative shoot height and irradiance on leaf properties Quercus serrata Thunb. saplings growing in the understory gaps were investigated. Photosynthetic photon flux (PPF) at location to that open (relative PPF; rPPF) base tree height; rHeight) measured for all current-year shoots each sapling. Current-year (length, area, number daughter shoots) mortality, (mass per area (LMA) nitrogen content (Narea)) examined relation rPPF rHeight. Narea was used as a proxy area-based...
The peripheral sensory nerve must be maintained to perceive environmental changes. Daily physiological mechanical stimulations, like gravity, floor reaction force, and occlusal influence the homeostasis directly or indirectly. Although direct axonal membrane stretch enhances axon outgrowth via mechanosensitive channel activation, indirect mechanisms remain elucidated. In this study, we identified pathways where Wnt5a was a molecular cue released by mechanically stimulated rat periodontal...
Japanese black bears, a large-bodied omnivore, frequently create small gaps in the tree crown during fruit foraging. However, there are no previous reports of bear-created canopy gaps. To characterize physical disturbance by we examined number parameters, including species trees which were created, gap size, horizontal and vertical distribution gaps, size branches broken to The was estimated using data from that had been dropped on ground. regime characterized highly biased ridges, large...
Hepatocellular adenoma (HCA) and hepatocellular carcinoma (HCC) can be difficult to differentiate but must diagnosed correctly as treatment prognosis for these tumors differ markedly. Relevant diagnostic biomarkers are thus needed, those identified in dogs may have utility human medicine because of the similarities between canine HCA HCC. A tRNA-derived fragment (tRF), tRNA-Val, is a promising potential biomarker mammary gland has not previously been investigated hepatic tumors. Accordingly,...
Lymphadenomegaly is well described in dogs with neoplastic diseases, but it can also reflect in-flammation. However, its role assessments of inflammation little reported the veterinary literature. Lymph nodes are most easily assessed superficially through palpation, computed tomography (CT) enables evaluation deep lymph nodes. Accordingly, we investigated associ-ations between maximal node diameter and plasma concentrations C-reactive protein (CRP), a sensitive inflammatory marker, targeting...
The transient receptor potential vanilloid type 1 (TRPV1) channel is a non-selective cation expressed with ankyrin (TRPA1) in small and medial size neurons of the dorsal root ganglions trigeminal ganglions. TRPV1 activated by capsaicin, thermal stimuli higher than 43°C, mechanical stress, protons (H + ). Although does not have positively charged residues at regular intervals on its transmembrane segments, alterations membrane also affect state channel. In presence voltage-dependent...