A5040308892- Pharmacy and Medical Practices
- Nausea and vomiting management
- Cancer Treatment and Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Colorectal Cancer Treatments and Studies
- Chemotherapy-induced organ toxicity mitigation
- Chemotherapy-related skin toxicity
- Pathogenesis and Treatment of Hiccups
- Lung Cancer Treatments and Mutations
- Anesthesia and Pain Management
- Safe Handling of Antineoplastic Drugs
- Cancer Immunotherapy and Biomarkers
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Sympathectomy and Hyperhidrosis Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Pharmaceutical studies and practices
- Hematopoietic Stem Cell Transplantation
- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- Pharmacovigilance and Adverse Drug Reactions
- Cancer, Stress, Anesthesia, and Immune Response
- Nephrotoxicity and Medicinal Plants
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pneumonia and Respiratory Infections
Keio University
2018-2025
Keio University Hospital
2025
Research Experiences for Undergraduates
2021-2024
National Cancer Center
2022
Tokyo Dental College Ichikawa General Hospital
2021
Ehime University Hospital
2009-2020
Nova Southeastern University
2020
Ibero American University
2018-2019
Shujitsu University
2013-2018
Ehime University
2009-2017
Background: Pembrolizumab is currently the standard treatment for patients with advanced non-small cell lung cancer (NSCLC).However, association between immune-related adverse events (irAEs) and peripheral blood counts remains unclear.We aimed at identifying that may predict development of pembrolizumab-induced irAEs.Methods: We retrospectively analyzed data on consecutive NSCLC who received pembrolizumab monotherapy as first-line or later-line therapy National Cancer Center Hospital Keio...
Abstract Background Proton pump inhibitors (PPIs) reduce the bioavailability of several anticancer drugs. The impact PPIs co-administered with cyclin-dependent kinase 4 and 6 is controversial. We aimed to clarify whether concomitant use impacts palbociclib abemaciclib effectiveness in breast cancer treatment. Patients Methods This multicenter, retrospective, observational study, conducted across medical institutions Japan, consecutively included patients endocrine-resistant metastatic...
The association between capecitabine efficacy and proton pump inhibitors (PPIs) is controversial. Here, we determined whether co-administration of PPIs affects the real-world effectiveness capecitabine. This retrospective observational study included consecutive patients with stage II-III colorectal cancer (CRC) who received adjuvant monotherapy or CapeOX (capecitabine oxaliplatin) January 2009 December 2014 at nine participating institutions. primary endpoint was difference in relapse-free...
Abstract Background: Potential novel strategies for adverse event (AE) management of osimertinib therapy, including therapeutic drug monitoring and the use biomarkers, have not yet been fully investigated. This study aimed to evaluate (1) relationship between exposure osimertinib, especially its active metabolites (AZ5104 AZ7550), AEs, (2) germline polymorphisms AEs. Methods: We conducted a prospective, longitudinal observational 53 patients with advanced non-small cell lung cancer receiving...
This study aimed to clarify the optimal value for unbound cefmetazole concentration remain above minimum inhibitory (MIC) (fT ≥ MIC) efficacy of de-escalation in patients with bacteremic urinary tract infection by extended-spectrum β-lactamase-producing Escherichia coli. double-center retrospective observational was conducted at Tokyo Bay Urayasu Ichikawa Medical Center and Keio University Hospital from January 2012 October 2022. Efficacy determined via clinical evaluation (mortality rate,...
Among patients with advanced non-small-cell lung cancer who were treated nivolumab monotherapy, the association of peripheral blood count data (at baseline and 2 weeks after treatment initiation) early onset immune-related adverse events (irAEs) efficacy has not been clearly established. This study aimed to identify that may be predictive development nivolumab-induced irAEs in a real-world clinical setting.This multicenter observational retrospectively evaluated consecutive undergoing...
We previously reported the results of a prospective study chemotherapy-induced nausea and vomiting (CINV) in cohort patients who received carboplatin-based chemotherapy were selected from nationwide registry those scheduled for moderately (MEC) or highly emetogenic (HEC) by CINV Study Group Japan. Of 1,910 registered (HEC: 1,195; MEC: 715), 400 chemotherapy. The frequency was determined, risk factors assessed.CINV data collected 7-day diaries. Risk identified using logistic regression...
Vonoprazan, a potassium-competitive acid blocker possessing new mechanism of action, was first approved in Japan 2015 for the treatment acid-related diseases. Vonoprazan inhibits secretion cells gastric wall. The inhibitory effect vonoprazan on H+,K+-ATPase is approximately 350 times greater than that lansoprazole, traditional proton pump inhibitor (PPI).1Echizen H. first-in-class blocker, fumarate: pharmacokinetic and pharmacodynamic considerations.Clin Pharmacokinet. 2016; 55:...
The purpose of this study was to assess the impact by switching co-administered triazole antifungal agent from fluconazole (FCZ) voriconazole (VCZ) on blood concentration tacrolimus (FK506) in patients receiving allogeneic hematopoietic stem cell transplantation. We performed a retrospective presented as case reports. FK506 increased after switch FCZ VCZ, resulting increase concentration/dose (C/D) ratio FK506. Thus, mean C/D ratios with oral administration surprisingly over 4.5-fold switch....
Olanzapine is an inexpensive and durable agent for the treatment of chemotherapy-induced nausea vomiting also superior to neurokinin-1 receptor antagonists in control nausea. This study aimed investigate efficacy safety a low dose 5 mg olanzapine plus granisetron dexamethasone carboplatin (CBDCA)-induced patients with thoracic malignancies.We conducted prospective, open-label, single-arm, multicenter, phase II trial four centers Japan. Registered were scheduled receive area under curve (AUC)...
Abstract Background Female sex and younger age are reported risk factors for chemotherapy‐induced nausea vomiting (CINV) in highly emetogenic chemotherapy, but the underlying mechanism has not been elucidated. The purpose of this study was to clarify impact menopause on CINV. Methods This retrospective observational analyzed data from consecutive patients who received their first cycle perioperative anthracycline‐based chemotherapy breast cancer between January 2018 June 2020. endpoints were...
Purpose:The aim of this study was to clarify the risk factors for discontinuing tegafur/gimeracil/oteracil potassium (S-1) adjuvant chemotherapy following gastrectomy in patients with gastric cancer.Methods: We retrospectively investigated curatively-resected cancer who received S-1 chemotherapy.S-1 administered orally at 80-120 mg/day, depending on body surface area, days 1-28 every 6 weeks 1 year.The dose and treatment schedule were modified clinicians' discretion, according...
Purpose As the major toxicity induced by pemetrexed plus carboplatin is severe hematologic toxicities, aim of this study was to determine risk factors for toxicities in lung cancer patients. Methods We retrospectively investigated data from patients who had received carboplatin, with or without bevacizumab. This observational carried out at Ehime University Hospital using electronic medical records dating July 2009 March 2015. Severe were defined as grade 3 4, according Common Terminology...
Reports on the therapeutic drug monitoring (TDM) of second- and third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer patients are limited required to improve safety EGFR-TKI therapy. Some EGFR-TKIs have active metabolites with similar or higher potency compared parent compounds; thus, compound as well its is essential for truly effective TDM. In this study, we developed validated a method that simultaneously quantifies...
Abstract Background Dasatinib, nilotinib, and bosutinib, second‐generation tyrosine kinase inhibitors (TKIs), ponatinib, a third‐generation TKI, are approved pharmaceuticals used in the treatment of chronic myeloid leukemia (CML). Although liquid chromatography‐tandem mass spectrometry assays for simultaneous quantification four TKIs human serum have been reported literature, high‐performance chromatography (HPLC) assay that simultaneously quantifies these compounds has not yet developed....
Abstract This study aimed to compare the antiemetic efficacy and safety of a four-drug combination with those standard three-drug in Japanese patients breast cancer treated anthracycline. We retrospectively analyzed data from cancer, who had received their first cycle anthracycline were aprepitant, palonosetron, dexamethasone or without olanzapine. retrospective observational was performed at Ehime University Hospital using electronic medical records. Multivariable propensity score-adjusted...
Community pharmacies play a significant role in home healthcare. However, patient information from hospitals is not shared with community pharmacies. We attempted the bidirectional sharing of regarding chemotherapy between and developed “medicine message board,” which was modified prescription format. Hospital pharmacists recorded patients taking tegafur/gimeracil/oteracil (S-1) on board. In turn, monitored side effects S-1 returned by fax to our hospital also using A medical clerk entered...
Treatment with antipsychotic drugs has been associated hyperprolactinemia. The same have also side effects such as menstruation disorders. aim of this study was to evaluate the prevalence hyperprolactinemia and disorders in women undergoing treatment. We performed a retrospective chart review psychiatric patients who underwent laboratory testing for serum prolactin (PRL) level between March 2011 2015 Ehime University Hospital. Patients presenting without were evaluated determine if they...
Background Olaparib-induced anemia is a frequently occurring complication in patients with advanced ovarian cancer, fallopian tube or primary peritoneal cancer and associated marked deterioration patients’ health-related quality of life. This study aimed to clarify patient-specific risk factors for severe breast receiving olaparib monotherapy real-world setting. Methods multicenter, retrospective, observational enrolled consecutively presenting who received as maintenance palliative...
Objective: Platinum- and anthracycline-based chemotherapy regimens cause nausea vomiting in clinical practice, resulting the deterioration of patients' QoL, discontinuation chemotherapy, reduced therapeutic outcomes. Using pica behavior as an indicator, we aimed to clarify whether anamorelin, orally active ghrelin receptor agonist, exerts antiemetic effects against cisplatin-induced rats. Materials Methods: Sprague–Dawley rats were treated with cisplatin (5 mg/kg, i.p.), three-drug or...