A5037439485- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Neutropenia and Cancer Infections
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Esophageal Cancer Research and Treatment
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Colorectal Cancer Surgical Treatments
Osaka City University Hospital
2016-2025
Kindai University
2022-2025
Kindai University Hospital
2023
Osaka City University
1992-2022
Kyoto Prefectural University
1996-2022
Juntendo University
2008-2014
Okayama University
2012-2014
Nihon University Itabashi Hospital
2003-2012
Kurashiki Central Hospital
2012
Tachikawa Hospital
2010
Both anabolism and catabolism of the amino acids released by starvation-induced autophagy are essential for cell survival, but their actual metabolic contributions in adult animals poorly understood. Herein, we report that, mice, liver makes a significant contribution to maintenance blood glucose converting via gluconeogenesis. Under synchronous fasting-initiation regimen, was induced concomitantly with fall plasma insulin presence stable glucagon levels, resulting robust acid release. In...
The lymphocyte-to-monocyte ratio (LMR) has been used as a parameter reflecting systemic inflammation in several tumors, and is reportedly associated with prognosis cancer patients. In this study, we evaluated the predictive value of LMR for progression chemosensitivity breast patients treated preoperative chemotherapy.LMR was 239 neoadjuvant chemotherapy (NAC) 5-fluorouracil, epirubicin, cyclophosphamide, followed by weekly paclitaxel or without trastuzumab, subsequent curative surgery....
Eribulin mesylate (eribulin) is currently indicated for treatment of locally advanced or metastatic breast cancer (MBC). It a cytotoxic agent with unique mechanisms that suppress epithelial-mesenchymal transition (EMT) cells. On the other hand, Tumor-infiltrating lymphocytes (TILs), which are considered indicators immune response monitoring, have been reported as prognostic factors and predictors therapeutic efficacy. We thought eribulin, has an EMT-inhibiting mechanism, may produce...
To evaluate the clinical effects of anti-tumor polysaccharide Schizophyllan (SPG), a randomized study was done on 220 patients with Stage II or III cervical cancer who had been given irradiation, concomitantly. The tumor-reducing effect SPG significant in either stage. time to recurrence longer SPG-dosed cancer, compared findings control group. There no difference between and groups. When comparing 48-month survival curve, group significantly than However, there rate SPG- dosed
Background/Aim: Recent interest has focused on the significance of tumor-infiltrating lymphocytes (TILs) efficacies and outcomes treatment in breast cancer (BC). Based recent international recommendation to standardize evaluation method, clinical validity utility TILs patients who underwent neoadjuvant chemotherapy (NAC) were investigated present study. Patients Methods: evaluated 177 with BC treated NAC subsequent curative surgery. The correlation between according standard method...
Eribulin mesylate (eribulin) is currently used for the treatment of locally advanced or metastatic breast cancer (MBC). It a cytotoxic agent with unique mechanisms that suppress epithelial-mesenchymal transition (EMT) cells and promote tumor vascular remodeling. In this study, we investigated expression markers EMT hypoxia in sets clinical specimens collected before after eribulin to verify its mechanisms.The cellular [E-cadherin, N-cadherin, vimentin, carbonic anhydrase 9 (CA9)] was...
Glutathione peroxidase (GSHPx) activity is an indicator of selenium status in selenium-deficient individuals. Utilizing polyclonal monospecific antibodies to purified erythrocyte GSHPx, we were able determine the relationship between enzymatic and protein content. In erythrocytes from a individual who was treated with selenium, HL-60 cells grown absence then returned selenium-containing medium, there direct Thus, deficiency results not only decrease GSHPx activity, but also protein.
The tumor immune environment not only modulates the effects of immunotherapy, but also other anticancer drugs and treatment outcomes. These responses can be evaluated with tumor-infiltrating lymphocytes (TILs), which has frequently been verified clinically. On hand, residual cancer burden (RCB) evaluation shown to a useful predictor survival after neoadjuvant chemotherapy (NAC). In this study, RCB TILs evaluations were combined produce an indicator that we have termed "RCB-TILs", its...
Tumour-infiltrating lymphocytes (TILs) can be used to monitor the immune tumour microenvironment (iTME) and predict treatment response outcome in breast cancer. We evaluated prognostic significance of levels CD8+ TILs forkhead box protein (FOXP3)-positive before after neoadjuvant chemotherapy (NAC).We examined 136 patients with cancer treated NAC. The number FOXP3+ biopsy specimens residual tumours was by immunohistochemistry.Patients a high rate change CD8/FOXP3 ratio (CFR) had...
During inflammation, lower molecular weight fragments of hyaluronan accumulate, and this is known to be inflammatory immune-stimulatory. In diseases such as bowel disease, cells bind hyaluronan; however, the cellular response mechanism hyaluronan–hyaluronan receptor interactions in mononuclear are not well understood. The expression receptors peripheral blood (PBMC) was examined. PBMC were stimulated with higher (molecular 100–150 kDa 2700 kDa) induction proinflammatory cytokines...
Triple-negative breast cancers (TNBCs) are defined as tumors that lack expression of estrogen receptor, progesterone receptor and human epidermal growth factor 2. Clinically, TNBC patients treated with cytotoxic drugs including 5-fluorouracil (5-FU). However, TNBCs develop resistance to such after a series treatments. To elucidate the mechanisms drug resistance, establishment drug-resistant cancer cell lines should be one most useful model systems. 5-FU-resistant have not been previously...
"Avoiding immune destruction" has recently been established as one of the hallmarks cancer. The programmed cell death (PD)-1/programmed death-ligand (PD-L) 1 pathway is an important immunosuppression mechanism that allows cancer cells to escape host immunity. present study investigated how expressions these checkpoint proteins affected responses neo-adjuvant chemotherapy (NAC) in breast A total 177 patients with resectable early-stage were treated NAC. Estrogen receptor, progesteron human...
The trastuzumab, pertuzumab, and docetaxel (TPD) regimen is strongly recommended as a treatment option for first-line therapy advanced human epidermal growth factor receptor (HER) 2-positive breast cancer. Monitoring the host microenvironments in cancer plays significant role predicting prognoses curative effects. It important to clarify of immune related gene expression tumor-infiltrating lymphocytes tumor microenvironment. In this study, we evaluated impact chemotherapy with TPD regimen,...
The association between capecitabine efficacy and proton pump inhibitors (PPIs) is controversial. Here, we determined whether co-administration of PPIs affects the real-world effectiveness capecitabine. This retrospective observational study included consecutive patients with stage II-III colorectal cancer (CRC) who received adjuvant monotherapy or CapeOX (capecitabine oxaliplatin) January 2009 December 2014 at nine participating institutions. primary endpoint was difference in relapse-free...
Heat shock cognate protein 70 (Hsc70) acts as a molecular chaperone for the maintenance of intracellular proteins, which allows cancer cells to survive under proteotoxic stress. We attempted use Hsc70 identify key molecules in cell survival. Here, we performed mass-spectrometry-based proteomics analysis utilizing affinity purification with anti-Hsc70 antibodies; result, 83 differentially expressed proteins were identified stress conditions. This result implies that there was change...
We hypothesized that there is reduced efficacy of fluorinated pyrimidines, such as capecitabine, caused by low active folic acid levels induced vitamin B12 deficiency, due to proton pump inhibitors (PPIs), and this can be recovered the administration leucovorin (LV). Thus, we retrospectively analyzed effects PPIs on adjuvant tegafur–uracil (UFT) plus LV for stage II/III colorectal cancer (CRC). Patients newly diagnosed with CRC who underwent curative surgery received UFT/LV therapy between...
Angiogenesis plays an important role in tumor progression. Several reports have demonstrated that a disintegrin and metalloproteinase with thrombospondin motifs1 (ADAMTS1) inhibited angiogenesis via multiple mechanisms. The aim of this study was to investigate the effect ADAMTS1 on endothelial cells vitro growth regard vivo. We examined effects transfection using two constructs, full-length (full ADAMTS1) catalytic domain-deleted (delta ADAMTS1). Transfection both full delta gene constructs...
Circulating tumor cells (CTCs) are linked to metastatic relapse and regarded as a prognostic marker for human cancer. High expression of plakoglobin, cell adhesion protein, within the primary is positively associated with CTC clusters in breast In this study, we investigated correlation between plakoglobin survival We evaluated 121 cancer patients treated neoadjuvant chemotherapy. Expression was identified by immunohistochemical staining membrane. also examined relation E-cadherin, an...
We screened a series of new epoxysuccinyl peptides for the development lysosomal cathepsin L-specific inhibitor. Among compounds tested, (2S,3S)-oxirane-2,3-dicarboxylic acid 2-[((S)-1-benzylcarbamoyl-2-phenyl-ethyl)-amide] 3-{[2-(4-hydroxy-phenyl)-ethyl]-amide} (compound CAA0225) was most potent inhibitor L. CAA0225 inhibited rat liver L with IC50 values 1.9 nM, but not B (IC50, >1000—5000 nM). To assess contribution to proteolysis, we evaluated autophagy, which is process self-degradation...
The prognosis of breast cancer and the treatment response to neoadjuvant chemotherapy (NAC) differ depending on intrinsic molecular subtypes. We evaluated prognostic significance immunohistological subtypes in patients with recurrent after NAC surgery.A total 237 treated subsequent curative surgery between 2007 2015 were analyzed. correlation clinicopathological features, prognosis, pathological complete (pCR) rate investigated retrospectively.There 55 (23.2%) recurrence surgery. No...
Background: Studies have found that patients with cancer exhibit abnormal leukocyte fractions, such as elevated neutrophil count and diminished lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR) provides a surrogate marker for prognosis response to treatment of after radical surgery several different types cancer. However, few reports addressed association between NLR endocrine therapy. In this study, we carried out clinical investigation confirm whether or not predicted therapy...
To determine whether the cyst fluid characteristics of endometrioma can be evaluated by magnetic resonance imaging (MRI), 36 endometriomas obtained from 24 patients (age range 21-43 years; mean 34 years) were studied. MRI was performed < 2 weeks before laparoscopy or laparotomy. Comparative studies density and concentration iron in signal intensity (SI) [calculated relaxation time T1 value, calculated T2 on a T1-weighted image (T1SI) T2-weighted (T2SI) cyst; T1SI/signal gluteus maximus...