Abstract Objectives The aim of this randomized controlled clinical trial was to compare the outcomes obtained in intrabony defects following regenerative periodontal surgery using single-flap approach (SFA) conjunction with either hyaluronic acid (HA) or enamel matrix derivative (EMD). Materials and methods Thirty-two 32 healthy subjects were randomly assigned: HA (test group) EMD (control group). Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), bleeding on...

Abstract Bone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone should be slowly resorbed replaced with native over time, accumulating evidence has in fact suggested the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage properties/features various indications, such as contour augmentation, sinus grafting, guided...

In-vitro data have shown that cross-linked hyaluronic acid (HA) enhances the proliferative and migratory properties of cells involved in periodontal wound healing/regeneration, stabilizes blood clot, reduces inflammatory response, facilitates angiogenesis. The aim this study was to histologically evaluate effects HA alone or combined with a collagen matrix (CM) on healing/regeneration intrabony defects.Two-wall defects (5 mm wide, 5 deep) were surgically created at distal mesial aspects...

To investigate the microbiological outcomes obtained with either subgingival debridement (SD) in conjunction a gel containing sodium hypochlorite and amino acids followed by subsequent application of cross-linked hyaluronic acid (xHyA) gel, or SD alone.

The aim of the present study was to evaluate effect a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects dogs.Two-wall (5 x 5 mm) were created surgically distal and mesial sides bilateral mandibular second fourth premolars four Beagle dogs. bFGF, enamel matrix derivative (EMD) platelet-derived with beta-tricalcium phosphate (PDGF/beta-TCP) treatments, sham-surgery (OFD) rotated among each animal, EMD PDGF/beta-TCP serving as...

Abstract Aim To clinically and histologically evaluate in dogs the healing of gingival recessions treated with coronally advanced flap (CAF) or without cross‐linked hyaluronic acid (HA). Materials methods Gingival recession defects were surgically created on vestibular side both maxillary canines 8 dogs. After weeks plaque accumulation, 16 chronic randomly either CAF alone HA‐gel (CAF/HA). Clinical histological outcomes evaluated at 10 post‐surgically. Results Compared to baseline, clinical...

To histologically evaluate the effects of cross-linked hyaluronic acid (xHyA) with or without a collagen matrix (CM) on periodontal wound healing/regeneration in class III furcation defects dogs.Class were surgically created mandibular premolars six beagle dogs. The randomly treated as follows: open flap debridement (OFD) + CM (CM), OFD xHyA (xHyA), (xHyA/CM) and alone (OFD). At 10 weeks, animals euthanized for histological evaluation.The newly formed bone areas (4.04 ± 1.51 mm2 ) xHyA/CM...

Abstract Objectives To compare the clinical outcomes obtained with either mechanical subgingival debridement in conjunction a sodium hypochlorite and amino acids containing gel followed by subsequent application of cross-linked hyaluronic acid (xHyA) gel, or alone. Materials Methods Fourty-eight patients diagnosed stages II-III (Grades A/B) generalised periodontitis were randomly treated scaling root planing (SRP) (control) SRP plus adjunctive hypochlorite/amino xHyA gels (test). The primary...

Background: A novel injectable, fast setting calcium phosphate cement (CPC) is currently used in orthopedic therapy for bone fractures. This study evaluated the possibility of applying this to healing periodontal defects. Methods: Fenestrations and 3‐walled defects were surgically created on bilateral first molars canines 5 beagle dogs. CPC was applied one side mandible. Untreated contralateral served as controls. all maxilla. Twelve weeks after surgery, animals sacrificed decalcified...

Background: Regeneration of lost periodontium is the ultimate goal periodontal therapy. Bone grafts, guided tissue regeneration, and application growth factors are used for regeneration. This study aimed to evaluate clinical efficacy a new, injectable calcium phosphate bone cement (CPC) in human intrabony defects. Methods: Thirty subjects (mean age, 53.4 ± 9.1 years) with periodontitis narrow defects were enrolled study. Subjects classified randomly into CPC graft group (N = 15) or open flap...

Abstract Objectives To evaluate periodontal wound healing following scaling and root planing (SRP) in conjunction with the application of sodium hypochlorite/amino acids cross-linked hyaluronic acid (xHyA) gels dogs. Materials Methods In four beagle dogs, 2-wall intrabony defects were created metal strips placed around teeth. Clinical parameters measured 4 weeks after plaque accumulation. The experimental surfaces subjected to SRP either subgingival a gel xHyA (test group) or alone (control...

This study sought to create a simple method for screening and detecting oral bacteria associated with periodontal disease as well identify the bacterial species that had strongest correlation severity in dogs. Fifty-two dogs from Kagoshima University Veterinary Teaching Hospital were included. The status, which included gingival recession, root surface exposure, redness, was determined through visual examination. Oral swab samples taken each dog's margin or tooth cervix using sterile cotton...

Background: An earlier study showed that an injectable calcium phosphate cement (CPC) served as a stable scaffold for bone formation and promoted histocompatible healing of periodontal tissue in dogs. In this study, we evaluated the influence CPC on regeneration defects with experimental periodontitis Methods: Experimental was induced by placing stainless‐steel mesh mesial side maxillary canines six adult, healthy beagle Subsequently, intrabony were resized so to be standard, injected...

Epidemiologic and clinical studies have indicated that diabetes is a risk factor for periodontal disease progression healing. The aim of the present study was to evaluate short-term healing after enamel matrix derivative (EMD) application in combined supra/infrabony defects diabetic rats.Thirty male Wistar rats were initially divided into two groups, one with streptozotocin-induced another healthy (non-diabetic) animals. Bony surgically created on mesial root first maxillary molars. After...

To evaluate periodontal wound healing/regeneration of one-wall intra-bony defects treated with recombinant human fibroblast growth factor-2 (rhFGF-2) and beta-tricalcium phosphate (β-TCP), carbonate apatite (CO3 Ap), or deproteinized bovine bone mineral (DBBM) in dogs.The stability rhFGF-2 adsorbed onto the substitutes was evaluated by Enzyme-Linked Immunosorbent Assay (ELISA). One-wall (5 × 5 mm) created five adult male beagle dogs were alone (rhFGF-2), β-TCP (rhFGF-2/β-TCP), CO3 Ap...

Abstract Objectives To histologically assess the effectiveness of a porcine‐derived collagen matrix ( CM ) and subepithelial connective tissue graft CTG for coverage single mucosal recessions at osseointegrated dental implants. Materials methods Chronic‐type M iller C lass I ‐like (mean clinical defect height: 0.67 ± 0.33–1.16 0.19 mm) were established buccal aspect titanium implants with platform switch in six beagle dogs. The defects randomly allocated to either (1) coronally advanced flap...

To evaluate the effect of a novel liquid carrier system enamel matrix derivative (Osteogain) soaked on an absorbable collagen sponge (ACS) upon periodontal wound healing/regeneration in furcation defects monkeys.The stability conventional (Emdogain) and Osteogain adsorbed onto ACS was evaluated by ELISA. Chronic class III were created at teeth 36, 37, 46, 47 three monkeys (Macaca fascicularis). The 12 assigned to one following treatments: (1) open flap debridement (OFD) + ACS, (2)...