Abstract Objective: Premature exposure of membranes used in guided bone regeneration (GBR) results decreased formation. The effect an expanded polytetrafluoroethylene (e‐PTFE) and two collagen membrane on healing buccal dehiscence defects around implants cases with without premature was clinically evaluated. Methods: Three groups were established: Group OS (Ossix™, n =73 implants, 41 patients), BG (Bio‐Gide®, =53 28 patients) GT (e‐PTFE, Gore‐Tex®, =34 17 patients). Defect height width...

Background: Acellular dermal matrix allograft (ADMA) has successfully been applied as a substitute for free connective tissue grafts (CTG) in various periodontal procedures, including root coverage. The purpose of this study was to clinically compare the efficiency ADMA and CTG treatment gingival recessions ≥4 mm. Methods: Seven patients with bilateral recession lesions participated. Fourteen teeth presenting mm were randomly treated or covered by coronally advanced flaps. Recession, probing...

The purpose of this article was to clinically evaluate the predictability a surgical procedure preserve alveolar ridge after extracting maxillary anterior teeth with advanced bone loss. This is indicated when tooth-supported fixed partial denture will rehabilitate area. Non-resorbable hydroxyapatite crystals are used as graft material and rotated pediculated split thickness palatal flap covers them. Twenty-three patients who were treated followed for 12 24 months. Results predictable minimal...

Abstract Objectives: Bone replacement substitutes are almost unavoidable in augmentation procedures such as sinus grafting. The objective of the present study was to evaluate osteoconductive capability two different scaffold fillers inducing newly formed bone this procedure. Material and Methods: Sinus floor implant placement were carried out bilaterally 12 patients. Bovine mineral (BBM) grafted on one side β ‐tricalcium phosphate ( ‐TCP) contralateral side. Both mixed (1:1 ratio) with...

The aim of this study was to evaluate histologically the bio-degradation two layers Bio-Gide((R)) (BG) membrane, as compared with that a single layer.Two circular calvarial bony defects, 5 mm in diameter, were made 24 Wistar rats. BG labeled biotin, cut into 5-mm-diameter disks, and placed defects either mono-layer membrane (MLM) or double-layer (DLM). Rats sacrificed after 4 9 weeks histology performed. Membranes stained horseradish peroxidase-conjugated streptavidin aminoethyl carbazole...

The evaluate the clinical outcome of bone augmentation with use particulate mineralized freeze-dried allograft (FDBA) or without addition autogeneous chips, applied in a bi-layered (BL) technique, covered by resorbable cross-linked collagen membrane.Fifty patients presenting vertical and/or lateral ridge deficiency at least 3 mm were included: Group FDBA, N=27 patients, FDBA was only graft; and BL, N=23 BL grafting procedure where autogenous chips inner layer outer. Bone graft ribose barrier...

Emdogain ® (EMD), a formulation of Enamel Matrix Proteins (EMP), is used clinically for periodontal regeneration, where it stimulates cementum formation and promotes gingival healing. In this study, we investigated the in vitro effects EMD on rat bone marrow stromal cells (BMSC) fibroblasts (GF). (at 25 μg/mL) increased osteogenic capacity marrow, as evidenced by ~ three-fold increase BMSC cell number two-fold alkaline phosphatase (ALP) activity mineralized nodule formation. The presence...

Abstract Background: Early barrier membrane degradation may result in decreased bone formation guided regeneration (GBR) procedures. The aim of this study was to evaluate the bio‐degradation cross‐linked (CLM) and non‐cross‐linked (NCLM) collagen membranes experimentally exposed oral environment animals. Methods: In eight cats, 48 surgical procedures were performed, three along each side palate: 24 full‐thickness soft tissue perforations made mini‐flaps raised. CLM or NCLM discs placed...

Abstract: Objective: This double‐blind study clinically and histologically evaluated long‐term barrier bio‐durability of cross‐linked non‐cross‐linked collagen membranes (CLM NCLM) in sites treated by guided bone regeneration procedures. Materials methods: In 52 patients, bony defects were randomly assigned to treatment with either a CLM or NCLM. Post‐surgical spontaneous membrane exposures recorded. Before implant placement, full‐thickness standard soft tissue discs retrieved wherever...

A lveolar ridge preservation following tooth extraction is important when implantsupported oral rehabilitation considered. The ability to maintain the allows implant placement in an ideal position, fulfilling both functional and esthetic demands. deproteinized bovine bone mineral (DBBM) was used as a socket site filler material configuration, without applying occlusive membrane. grafted packed onto sites immediately after extractions, subsequently primary soft tissue closure attempted....

Accurate implant placement in the anterior maxilla is essential achieving optimal prosthetic rehabilitation with proper function and acceptable esthetic phonetic demands. One of preferable solutions to restore a missing maxillary incisor young adults by an implant‐supported crown. Bone resorption together enlarged incisive foramen, challenge placement. A simultaneous procedure where osteotomy site penetrated canal presented. configurated cortico‐cancellous block graft core was adjusted fit...

Background: Xenografts to augment the maxillary sinus have been used extensively. The aim of present study was evaluate, qualitatively and quantitatively, two different HA derivatives natural synthetic sources on newly formed bone in augmented sinus. Methods: A bilateral augmentation procedure with simultaneous (16 out 20 sites) or subsequent implant placement performed 10 patients. antrum randomly filled a deproteinized, bovine hydroxyapatite mineral (B‐HA) one side non‐ceramic resorbable...

Abstract: The purpose of this study was to evaluate the clinical healing buccal marginal defects around implants placed in fresh extraction sockets or after several weeks together with barrier membranes and bone graft. Two implant placement protocols were compared: delayed‐immediate sites primarily closed by a rotated (full thickness) palatal flap (RPF) at time tooth implantation 4–6 (Group 1, 24 patients, n = 31 implants) immediate procedures (into sockets) split (RSPF) 2, 19 23 implants)....

Background: Free grafts, pedicle flaps, and barrier membranes have been used to cover exposed root surfaces. The aim of the present study was evaluate clinical efficacy a coronally advanced flap procedure with additional use enamel matrix protein derivative (EMD) treat gingival recession compare it subpedicle connective tissue graft (CTG). Methods: conducted in six different periodontal clinics. Miller Class I or II buccal type defects anterior premolar teeth were treated 70 consecutive...

Background: Collagen barrier membranes are commonly applied in periodontal and bone‐regenerative procedures. Membranes differ their resorption pattern following implantation, thus influencing clinical outcome. The purpose of this study was to quantitatively evaluate the biodegradation three different commercially available collagen membranes. Methods: were cut into 5‐mm‐diameter disks labeled with aminohexanoyl‐biotin‐N‐hydroxy‐succinimide ester. One membrane disk each type (non‐cross‐linked...

The aim of this study was to examine the efficacy a new biphasic hydroxyapatite/tricalcium phosphate (HA/TCP) bone substitute in combination with particulate autogenous sinus floor augmentation procedures.A simultaneous or two-stage and implant placement were conducted 28 patients. A mixture HA/TCP chips 1 : ratio used as grafting biomaterial. Cylindrical specimen retrieval performed all patients except one. Specimens harvested either at 6 (n=14) 9 (n=13) months post-augmentation. For...

Emdogain ® , a formulation of Enamel Matrix Proteins, is used clinically for periodontal regeneration to stimulate PDL (periodontal ligament), cementum, and bone formation. Its effects on gingival fibroblasts tissue have not been thoroughly studied. Therefore, we investigated the mechanisms by which affects cell cycle human fibroblasts. Without serum, (50 μg/mL) induced fibroblast entry into S phase DNA synthesis, but completion cycle. With low serum concentrations (0.2–0.5%),...

To evaluate the 4-year results following regenerative periodontal surgery at intra-bony defects with either a combination of an enamel matrix protein derivative (EMD) and bioactive glass (BG) or EMD alone.Twenty-five patients one deep defect each were randomly treated EMD+BG (test) alone (control). Measurements recorded baseline, 1 4 years therapy. The primary outcome variable was clinical attachment level (CAL).The test group demonstrated mean CAL change from 10.3+/-1.6 to 6.7+/-1.2 mm...

Immediate implant placement after tooth extraction is becoming a common procedure in implant‐supported oral rehabilitation. However, lack of primary full flap closure can jeopardize final results. A surgical approach that would enable predictable soft tissue over implants placed into fresh sockets described and evaluated. This technique based on rotated deep split thickness palatal (RSPF) containing periosteum connective tissue, covering the and/or barrier membrane. In 29 patients, 33...

Background: Implants can be placed at the time of tooth extraction (immediate), after several weeks (delayed), or complete healing (late). The purpose this study was to evaluate clinical bone buccal dehiscence‐type defects around maxillary implants together with bioabsorbable collagen barrier membranes and graft 3 points. Methods: Three implant placement protocols were compared: immediate procedures primarily closed by a rotated split palatal flap (19 patients, 23 implants; group 1); delayed...

Gingival esthetics has become an important factor in the overall success of most maxillary implant-supported restorations. Periodontal plastic surgery procedures may be used to enhance anterior region. The purpose present study was evaluate a new surgical approach, performed at implant exposure, reconstruct interdental papillae around restorations.The procedure on 32 patients, which 36 consecutive single tooth osseointegrated implants were exposed and premolar Previous exposure 6 months...

Bovine mineral spongiosa block (B-SB) was used as a bone substitute in sinus augmentation procedures 10 consecutive patients. Implants were placed during the same session. The purpose of this study to histopathologically examine healing grafted site around implants at 12 months. Radiographic follow-up showed apparent apposition augmented area implants. Clinically, all 36 stable and integrated with surrounding tissue. Histopathologically, new formation evident specimen hard tissue cores....