A5011133566- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal motility and disorders
- Cardiovascular Function and Risk Factors
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Cancer-related gene regulation
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microscopic Colitis
- Diverticular Disease and Complications
Fujita Health University
2015-2024
Fujita Health University Hospital
2014-2023
Weatherford College
2021
Niigata University
2012-2019
National Institute of Biotechnology
2001-2009
Czech Academy of Sciences, Institute of Biotechnology
2001-2009
University Gastroenterology
2009
Gifu University of Medical Science
2007
Institute of Applied Biochemistry
2000-2002
Osaka Medical and Pharmaceutical University
1999-2002
MicroRNAs (miRNAs) are endogenously expressed RNAs, 18—25 nucleotides in length, that repress protein translation through binding to target mRNAs. miRNAs have been implicated many cellular processes including cell proliferation, differentiation, and death. Recently, let-7 were found regulate human RAS oncogene expression be often down-regulated lung tumors. In this study, we examined the of colon cancer tumors lines, with result 2 6 cases 1 3 lines showed reduced let-7. When low-expressing...
<i>Objective:</i> Downregulation of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs tumor suppression. We investigated the role miR-143 and miR-145 gastric cancers. <i>Methods:</i> The expression levels samples from 43 patients with cancer were determined by real-time PCR using TaqMan assay. growth inhibitory effect was estimated transfection cells miRNA. <i>Results:</i> -145 decreased most cancers examined, as...
Recently, it has been found that inappropriate expression of microRNAs (miRNAs) is strongly associated with carcinogenesis. In this study, we demonstrated the miRNAs (miRs) ‐143 and ‐145, levels which were previously shown to be reduced in colon cancers various kinds established cancer cell lines, was also decreased most B‐cell malignancies examined, including chronic lymphocytic leukemias (CLL), lymphomas, Epstein‐Barr virus (EBV)‐transformed Burkitt lymphoma lines. All samples from 13 CLL...
Mangosteen, Garcinia mangostana Linn, is a tree found in South East Asia, and its pericarps have been used as traditional medicine. Phytochemical studies shown that they contain variety of secondary metabolites, such oxygenated prenylated xanthones. Recent revealed these xanthones exhibited biological activities containing anti-inflammatory, anti-bacterial, anti-cancer effects. We previously investigated the anti-proliferative effects four from pericarps; alpha-mangostin, beta-mangostin,...
Arsenic trioxide (As 2 O 3 ) induces clinical remission in acute promyelocytic leukemia, even all‐ trans retinoic acid‐refractory cases, with minimal toxicity at low (1–2 μM) concentration. We exposed various neuroblastoma cell lines to As a concentration of μM: as result, seven 10 underwent apoptosis characterized by morphological changes and nucleosomal DNA fragmentation. ‐induced cells was shown occur through the activation caspase 3, judged from Western blot analysis inhibition assay. It...
Abstract The role of mitochondrial permeability transition (PT) in apoptosis induced by an endogenous neurotoxin, N ‐methyl( R )salsolinol [ M( )Sal], was studied use dopaminergic neuroblastoma SH‐SY5Y cells. )Sal reduced membrane potential, ΔΨm, the early phase apoptosis, which not suppressed a pan‐caspase inhibitor, but antagonized Bcl‐2 and cyclosporin A, suggesting involvement PT )Sal‐induced loss ΔΨm. completely inhibited only also essential apoptosis. In mitochondria isolated from rat...
// Kohei Taniguchi 1, 2 , Miku Sakai 1 Nobuhiko Sugito Minami Kumazaki Haruka Shinohara Nami Yamada Tatsushi Nakayama Hiroshi Ueda Yoshihito Nakagawa 3 Yuko Ito 4 Manabu Futamura 5 Bunji Uno Yoshinori Otsuki Kazuhiro Yoshida Kazuhisa Uchiyama Yukihiro Akao United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 501-1193, Japan Department General Gastroenterological Surgery, Osaka College, Takatsuki, 569-8686, Gastroenterology, Fujita Health Medicine,...
In a variety of cancers, altered patterns microRNA (miRNA) expression are reported and may affect the cell cycle survival. Recent studies suggest that level miRNAs act as tumor suppressors is frequently reduced in cancers because chromosome deletions, epigenetical changes, aberrant transcription disturbances miRNA processing. miR-143 -145, which located approximately 1.3 kb from each other at 5q33, highly expressed several tissues, but down-regulated most cancers. However, mechanism this...
Colorectal cancer is one of the leading causes cancer-related death worldwide. Previous studies have shown that miR-92a has an oncogenic function in several cancers and its up-regulation correlated with malignant clinicopathologic behaviors colorectal cancer. It also been suggested circulating patients' plasma can be a potential biomarker for However, precise roles intracellular extracellular are not yet understood. In this study, we examined expression levels tumors (38 specimens 56 adenoma...
Abstract The Warburg effect is a well-known feature of cancer cells. However, its' functional significance hasn't been elucidated yet. Pyruvate kinase muscle (PKM), which rate-limiting glycolytic enzyme, has 2 isoforms, PKM1 and PKM2. It reported that PKM2 tumor-specific isoform promotes the effect. Also, it thought tumor cells switch their PKM from to during development. Here, we showed this switching machinery was induced only in limited cases, based on expression normal tissues...
The combination of atezolizumab plus bevacizumab (Atz/Bev) has become widely used as a first-line therapy for advanced hepatocellular carcinoma (HCC). However, post-Atz/Bev therapy, evidence on the outcomes molecular targeted agents, such lenvatinib, is limited. present study aimed to assess clinical effectiveness lenvatinib HCC in patients who had previously undergone Atz/Bev treatment.Twenty with HCC, received after treatment, were enrolled study. In particular, we examined impact adverse...