A5023799318- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Bioactive Compounds and Antitumor Agents
- Colorectal Cancer Treatments and Studies
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Gastric Cancer Management and Outcomes
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
- Ferrocene Chemistry and Applications
Tokyo National Hospital
2020-2025
National Cancer Center Hospital East
2021-2024
Kitasato Institute Hospital
2024
Kitasato University
2017-2024
National Cancer Center
2023
Yamato Municipal Hospital
1998-2019
National Cancer Centre Japan
2019
St. Marianna University School of Medicine
2013-2019
Tokai University Hospital
2017
Yokosuka Kyosai Hospital
2013-2017
Estrogens are potent mammary tumor promoters influencing post-initiation events via epigenetic mechanisms. The upregulation (i.e., induction) of the C16 alpha-hydroxylation pathway during 17 beta-estradiol (E2) biotransformation has been associated with cell transformation. action E2 metabolites on tumorigenic transformation, however, is poorly understood.The newly established epithelial line C57/MG, derived from C57BL mouse strain, was used to examine whether or its metabolites,...
The incidence of breast cancer has progressively increased, making it the leading cause deaths in Japan. Breast accounts for 20.4% all new cancers with a reported age-standardized rate 63.6 per 100 000 women.The Japanese guidelines screening were developed based on previously established method. efficacies mammography and without clinical examination, examination ultrasonography evaluated. Based balance benefits harms, recommendations population-based opportunistic screenings formulated.Five...
Background A strategy for maintaining and/or improving cardiorespiratory fitness (CRF) in the growing population of cancer survivors is major clinical importance, especially COVID-19 era. The effect unsupervised high-intensity interval training (HIIT) on increasing CRF breast unknown. Purpose purpose this study was to determine whether newly developed habit-B programme, which involves home-based smartphone-supported HIIT using body weight exercises, improves early-stage survivors. Methods...
Abstract Ductal carcinoma in situ (DCIS) is a precursor to invasive breast cancer. The frequency of DCIS increasing because routine mammography; however, the biological features and intratumoral heterogeneity remain obscure. To address this deficiency, we performed single-cell transcriptomic profiling ductal (IDC). was found be composed several transcriptionally distinct subpopulations cancer cells with specific functions. Several transcripts, including long noncoding RNAs, were highly...
Triple-negative breast cancer (TNBC) is negative for hormone receptors and human epidermal growth factor receptor 2 (HER2). In stage I TNBC, adjuvant therapy or follow-up are performed according to risk factors, but clinical trial data scarce. recent years, it has been reported that HER2-low cases (1+/2+ in situ hybridization negative) have different prognoses than HER2-0 cases. However, the of recurrence factors this population TNBC not yet investigated.Herein, out 174 patients with who...
ABSTRACT Despite the importance of genetic testing for risk assessment and treatment in breast cancer, prognostic impact germline pathogenic variants (PVs), especially Asian populations, is unclear. We assessed PVs patients with early‐stage cancer. This study included 7278 Japanese multihospital registry patients. ATM , BRCA1 BRCA2 CDH1 CHEK2 NBN NF1 PALB2 PTEN STK11 TP53 were evaluated. PV non‐PV carriers matched by age, histology, stage. Associations between survival assessed. The primary...
The results of in vitro chemosensitivity testing using the MTT assay tumor cells from 140 patients were analyzed with reference to clinical antitumor effects chemotherapy. One hundred and twenty-four (88.6%) specimens successfully tested by method Mosmann (J Immunol Methods 65:55-63, 1983) some modifications. When compared chemotherapy 22 remaining measurable lesions, overall prediction rate was 86.4% (19/22). Among 31 stage III-V gastric colorectal carcinomas without survival nine treated...
Abstract Tumor cells from 40 patients were tested by MTT assay. Five thousand to sixteen tumor plated into 96‐well microplates with various concentrations of anticancer agents. After incubation for 48 h, the absorbance each well was detected an EIA reader and effects agents evaluated as positive when inhibition rate equal or more than 50%. Normal also processed under same conditions, normal lower that statistical significance ( P < .05). The efficacy rates MMC, 5‐FU, ADM, CDDP 16.7, 8.3,...
523 Background: The possibility of primary tumor resection (PTR) improving the survival de-novo Stage IV breast cancer (dn-StIV BC) patients has been evaluated by several prospective studies but remains controversial. We designed this phase 3 trial (JCOG1017) comparing with/without dissection after initial systemic therapy based on clinical subtype in dn-StIV BC patients. Methods: Dn-StIV were enrolled first registration. All received therapies according to subtypes. not showing refractory...
Mammography screening has increased the detection of subcentimeter breast cancers. The prognosis for estrogen receptor (ER)-positive and human epidermal growth factor 2 (HER2)-negative T1a/bN0M0 cancers is excellent; however, necessity adjuvant endocrine therapy (ET) uncertain. We evaluated effectiveness ET in patients with ER-positive HER2-negative cancer who underwent surgery from 2008 to 2012. Standard was administrated after surgery. primary endpoint cumulative incidence distant...
// Kazuhiro Kitajima 1 , Yasuo Miyoshi 2 Tetsuro Sekine 3 Hiroyuki Takei 4 Kimiteru Ito 5 Akihiko Suto 6 Hayato Kaida 7 Kazunari Ishii Hiromitsu Daisaki 8 and Koichiro Yamakado Department of Radiology, Hyogo College Medicine, Hyogo, Japan Breast Endocrine Surgery, Nippon Medical School Hospital, Tokyo, Surgery Oncology, Diagnostic National Cancer Center Kinki University Faculty Osaka, Radiological Technology, Gunma Prefectural Health Sciences, Maebashi, Correspondence to: Kitajima, email:...
The impact of progesterone receptor (PR) status on the prognosis breast cancer after isolated locoregional recurrence (ILRR) remains unclear. This study evaluated clinicopathologic factors, including PR ILRR, distant metastasis (DM) ILRR.We retrospectively identified 306 patients with ILRR diagnosed at National Cancer Center Hospital between 1993 and 2021 from database. Cox proportional hazards analysis was performed to examine factors associated DM ILRR. We developed a risk prediction model...
Abstract Purpose Stromal tumor-infiltrating lymphocytes (TILs) are independent prognostic factors in systemically untreated early-stage triple-negative breast cancer (TNBC). Other immune biomarkers including CD8, CD20, programmed cell death-ligand 1 (PD-L1), and tertiary lymphoid structures (TLS) also reported to be associated with prognosis. However, whether combining other TILs would allow for further stratification is unknown. Methods We retrospectively analyzed 125 patients TNBC not...
Curebest™ 95GC breast (95GC) is a multigene classifier we developed for the prognostic prediction of patients with estrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-negative and node-negative (ER+/HER2-/n0) invasive cancer treated adjuvant endocrine therapy alone. The aim preset study was to evaluate clinical utility in multiinstitutional registry study. Patients (n=215) ER+/HER2-/n0 who had undergone assay seven hospitals were consecutively recruited at various...
Due to the increase in number of early-stage breast cancer patients, there is growing interest minimally invasive local therapies for cancer. Radiofrequency ablation (RFA) therapy one most promising treatments. The Ablation Therapy Early Breast Cancer as Local (RAFAELO) study, a multicenter collaborative study that aims validate efficacy and safety RFA standardize its use cancer, was conducted under Advanced Medical Care B system 2013. This enrolled expected patients November 2017; moreover,...
Experimental chemotherapy with 5‐fluorouracil (5‐FU; 60 mg/kg), l‐hexylcarbamoyl‐5‐fluorouracil (HCFU; 70 3‐(3‐(6‐benzoyloxy‐3‐cyano‐2‐pyridyloxycarbonyI)benzoyl)‐l‐ethoxymethyl‐5‐fluorouracil (BOF‐A2; 30 mg/kg) and UFT (20 mg/kg as tegafur uracil at a molar ratio of 1:4) was performed using human gastric (H‐111) colon (Co‐4) carcinoma strains in nude mice. 5‐FU administered ip q4d × 3 schedule the other agents were given po daily for three weeks. Concentrations serum tumor assessed by gas...
Although the categorization of ultrasound using Breast Imaging Reporting and Data System (BI-RADS) has become widespread worldwide, problem inter-observer variability remains. To maintain uniformity in diagnostic accuracy, we have developed a system which artificial intelligence (AI) can distinguish whether static image obtained breast represents BI-RADS3 or lower BI-RADS4a higher to determine medical management that should be performed on patient whose shows abnormalities. establish...
The occurrence of iatrogenic tumor cell seeding (seeding) in needle tract scars formed by core biopsy (CNB) or vacuum-assisted (VAB) is well known. Some risk factors for have been reported, but the clinicopathological and its prognosis not fully investigated. We evaluated clinical features seeding.We included 4405 patients who had undergone surgery (lumpectomy mastectomy) with a diagnosis breast cancer preoperative CNB VAB at our hospital between January 2012 February 2021. Data confirmed...
One hundred and forty-eight patients with gastric cancer admitted to Keio University Hospital between July 1988 October 1992 underwent resection of the primary lesion, as well single-cell suspension assay fresh surgical materials 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) for chemosensitivity evaluation. Fifty histologically stage III or IV were enrolled in this study, among whom 10 received no chemotherapy after surgery while 40 at equivalent dose levels...