A5036028114- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Lung Cancer Diagnosis and Treatment
- Microwave Imaging and Scattering Analysis
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Geophysical Methods and Applications
- MRI in cancer diagnosis
- HER2/EGFR in Cancer Research
- Medical Imaging and Pathology Studies
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Bone health and treatments
- Wnt/β-catenin signaling in development and cancer
- Inflammatory Biomarkers in Disease Prognosis
Hiroshima University
2016-2025
Hiroshima University Hospital
2014-2024
Higashihiroshima Medical Center
2018-2024
Weatherford College
2023
Wakayama Medical University
2023
Hiroshima City University
2016-2019
National Cancer Center
2015
Virginia Department of Environmental Quality
2014
Accreditation Council for Graduate Medical Education
2014
Pediatric Oncology Group
2014
In this report, a hand-held impulse-radar breast cancer detector is presented and the detectability of malignant tumors demonstrated in clinical test at Hiroshima University Hospital, Hiroshima, Japan. The core functional parts consist 65-nm technology complementary metal-oxide-semiconductor (CMOS) integrated circuits covering ultrawideband width from 3.1 to 10.6 GHz, which enable generation transmission Gaussian monocycle pulse (GMP) with 160 ps single port eight throw (SP8T) switching...
The Japanese Breast Cancer Society (JBCS) Clinical Practice Guidelines for systemic treatment of breast cancer were updated to the 2022 edition through a process started in 2018. guidelines consist 12 background questions (BQs), 33 clinical (CQs), and 20 future research (FRQs). Multiple outcomes including efficacy safety selected each CQ, then quantitative qualitative systematic reviews conducted determine strength evidence recommendation, which was finally determined voting among designated...
Emerging evidence indicates that small RNAs, including microRNAs (miRNAs) and their isoforms (isomiRs), transfer RNA fragments (tRFs), are differently expressed in breast cancer (BC) can be detected blood circulation. Circulating RNAs extracellular vesicles (EVs) have emerged as ideal markers RNA-based applications for detection. In this study, we first undertook sequencing to assess the expression of circulating serum BC patients cancer-free individuals (controls). Expression 3 namely...
FOXP3 + and CD8 are recognized markers of tumor-infiltrating lymphocytes (TILs) for breast cancer. TILs composed effector Tregs (eTregs) other subpopulations that classified by their differences in suppressive function. In this prospective study, we evaluated Treg cancer.84 patients with cancer were enrolled. Fresh extracted andTregs into eTregs (CD4+FOXP3highCD45RA-), FOXP3+ subsets (naïve non-Tregs), total CD8+CD4- using flow cytometry. The suppression strength each subpopulation was...
There is uncertainty as to which factors determine the aggressiveness of lung adenocarcinoma with a micropapillary pattern (MPP). The present study aimed clarify influence MPP on malignant clinical stage IA adenocarcinoma. We retrospectively examined 347 consecutive patients who underwent complete resection. defined MPP-positive accounting for ≥5% entire tumour. Forty-eight (14%) and 299 (86%) were negative, respectively. Lymphatic ( P = 0.003) vessel 0.029) invasion well lymph node...
Though there are no evidences that postoperative therapy improves overall survival (OS) in stage I-II endometrial carcinoma, many women receive radiation or chemotherapy. This study aimed to investigate the baseline risk of recurrence after complete resection without any adjuvant therapies and suppose validity for carcinoma.Charts patients with carcinoma who underwent operation between January 2005 December 2011 were retrospectively reviewed prognosis assessed. Risk classifications performed...
The objective of this paper is to investigate the detectability breast tumors having various histological types in excised tissues total mastectomy. tumor images measured by a portable impulse-radio-ultra-wideband (IR-UWB)-radar-based cancer detector are compared with both pathological and dedicated positron emission tomography. It found that can detect invasive-ductal-carcinomas extensive intraductal component dense breast. density has correlation effective permittivity derived from...
Abstract Background In breast cancer patients receiving neoadjuvant chemotherapy (NAC), immediate reconstruction (IBR) as a treatment option remains controversial. We assessed the impact of NAC on surgical and oncological outcomes undergoing IBR. Methods This was retrospective multicenter study 4726 cases The rate postoperative complications survival data were compared between IBR who received those did not receive NAC. Propensity score matching analysis performed to mitigate selection bias...
Radar-based microwave imaging is a promising technique for multiple medical applications, such as breast health monitoring, cancer detection, ablation and chemotherapy monitoring. In our previous work, hand-held multistatic CMOS impulse-radar detector was developed. It designed to be placed directly on the patient in supine position without coupling medium. radar-based imaging, surface clutters, which are generated from skin reflection, imperfect contacts, antenna coupling, deteriorate...
Mammography screening has increased the detection of subcentimeter breast cancers. The prognosis for estrogen receptor (ER)-positive and human epidermal growth factor 2 (HER2)-negative T1a/bN0M0 cancers is excellent; however, necessity adjuvant endocrine therapy (ET) uncertain. We evaluated effectiveness ET in patients with ER-positive HER2-negative cancer who underwent surgery from 2008 to 2012. Standard was administrated after surgery. primary endpoint cumulative incidence distant...
Abstract Background Immediate breast reconstruction (IBR) is a common oncoplastic procedure used in cancer surgery. This study aims to investigate compliance with prosthetic guidelines and its impact on perioperative treatment. Methods We reviewed data from the National Clinical Database-Breast Cancer Registry between January 2019 December 2020. compared treatment implementation IBR non-IBR groups by subtype matching for age, menopausal status, T stage, N histology. Results A total of 8,860...
Abstract This is an annual report by the Japanese Breast Cancer Society, which provides statistics on clinical data breast cancer in Japan, extracted from National Clinical Database-Breast Registry (NCD-BCR). includes update of 102,453 cases at 1339 institutions registered NCD-BCR 2022. Among 101,793 female patients, median age diagnosis was 62 years (interquartile range, 50–73 years), and 29.4% patients were premenopausal. Of these 15,437 (15.2%) 42,936 (42.2%) diagnosed with stage 0 I...
Radiofrequency ablation (RFA) is considered a promising alternative to surgical excision for patients with small, unifocal early-stage breast cancer. A significant concern the application of RFA in diagnosed ductal carcinoma situ (DCIS) via needle biopsy underdiagnosis invasive The extent this DCIS eligible has not been clearly defined. This retrospective study assessed lesions as and at our institution from April 2009 March 2024. eligibility criteria included lesion size ≤ 1.5 cm,...
Breast cancer stem cells are a promising therapeutic target in cancer. We explored breast cell diversity and establish methodology for selectively culturing cells. collected tissues from surgical samples of treatment-naïve patients with estrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-negative Following isolation, were subjected to spheroid culture on non-adherent plates. Of the 57 cases, successful was achieved 48 among which average ratio CD44+/CD24− increased 13.8%...
Axillary staging is commonly performed in patients with clinically node-positive (cN+) breast cancer undergoing neoadjuvant chemotherapy (NACT), regardless of pathological complete response (pCR). Recent evidence has suggested that ypT0 correlates ypN0 and favorable prognosis, potentially supporting the omission axillary such cases. This study aimed to evaluate as a predictive factor for ypN status its prognostic significance cN+ treated NACT. retrospective included 302 NACT at Hiroshima...
Metabolomics has developed as an important new tool in cancer research. It is expected to lead the discovery of biomarker candidates for diagnosis and treatment. The current study aimed perform a comprehensive metabolomic analysis intracellular dynamic responses human gastric cells 5-fluorouracil (5-FU), referencing mechanisms drug action resistance. Small metabolites 5-FU-resistant were measured by liquid chromatography-mass spectrometry. Candidates targets selected according presence or...
To develop and validate a 3-year recurrence prediction score (RPS) system for predicting the baseline risk of stage I-II endometrial carcinoma.We reviewed 427 patients with International Federation Gynecology Obstetrics staging carcinoma underwent surgery without any adjuvant therapy from 2005 to 2013. The were divided into 2 groups: test cohort (n=251) comprising those who in odd-numbered years, validation (n=176) even-numbered years. Multivariate analysis was performed using 7 candidate...
The purpose of this study is to develop an image artifact removal method for radar-based microwave breast imaging and demonstrates the detectability on excised tissues total mastectomy.