A5103069601- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- IL-33, ST2, and ILC Pathways
- Chemotherapy-related skin toxicity
- Neutropenia and Cancer Infections
- Cancer Cells and Metastasis
- Cancer Risks and Factors
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- MRI in cancer diagnosis
- Fungal Infections and Studies
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Maternal and Perinatal Health Interventions
- Advanced Radiotherapy Techniques
- Anesthesia and Sedative Agents
- Metastasis and carcinoma case studies
- Congenital Diaphragmatic Hernia Studies
Hiroshima City Asa Citizens Hospital
2022-2023
North Medical Center
2022-2023
Hiroshima University
2018-2022
Hiroshima Kyoritsu Hospital
2022
Hiroshima University Hospital
2017-2019
Hiroshima City University
2019
Hiroshima General Hospital
2015
FOXP3 + and CD8 are recognized markers of tumor-infiltrating lymphocytes (TILs) for breast cancer. TILs composed effector Tregs (eTregs) other subpopulations that classified by their differences in suppressive function. In this prospective study, we evaluated Treg cancer.84 patients with cancer were enrolled. Fresh extracted andTregs into eTregs (CD4+FOXP3highCD45RA-), FOXP3+ subsets (naïve non-Tregs), total CD8+CD4- using flow cytometry. The suppression strength each subpopulation was...
Triple-negative breast cancer (TNBC) is characterized by an active immune response. We evaluated intratumoral interrelation between FOXP3+ tumor-infiltrating lymphocytes and other cytokines in TNBC. Network analysis refined significantly correlate with FOPX3 Information on the treatment response prognosis of patients, survival data from TGCA METABRIC databases were analyzed according to cytokines. Interleukin (IL)-33 was expressed TNBC cell lines compared luminal (log2 fold change: 5.31, p <...
Triple-negative breast cancer (TNBC) is characterized by an active immune response. We evalu-ated intratumoral interrelation between FOXP3+ tumor-infiltrating lymphocytes and other cy-tokines in TNBC. Network analysis refined cytokines significantly correlate with FOPX3 Treatment response prognosis imformation of patients survival data from the TGCA METABRIC databases were analyzed according to cytokines. Interleukin (IL)-33 was sig-nificantly expressed TNBC cell lines than luminal (log2...
Background/Aim: The characteristics of different breast cancers imaged using dual-energy computed tomography (DECT) are unknown. Furthermore, the differences between DECT and magnetic resonance imaging (MRI) in ability to assess tumor extent have not been clarified. Therefore, this study aimed evaluate effectiveness iodine maps compared contrast-enhanced MRI patients with operable cancer. Patients Methods: Clinicopathological data from 858 cancer who underwent resection after (100/140 kv)...
Abstract Purpose: FOXP3+ tumor-infiltrating lymphocytes (TILs) are prototypical immunosuppressive TILs in breast cancer. However, the TIL subset of effector regulatory T cells (eTregs) cannot be detected with conventional immunohistochemical staining. Therefore, we evaluate potential eTregs and role immunostimulatory CD8+ invasive Methods: Fresh were extracted from 84 patients cancer divided into CD4 + FOXP3 (Tregs) cytotoxic (CTLs) by flow cytometry. Tregs further classified (CD4 high...
Morgagni hernia is a rare form of diaphragmatic hernia. It located at the anterior edge diaphragm and does not have an rim. difficult to achieve secure closure maintain tension with laparoscopic surgery. We performed resection colorectal cancer repair simultaneously. An 89-year-old woman underwent ileocecal Regarding repair, we considered that it would be use mesh from viewpoint infection due colectomy. Therefore, done extra-abdominal suture method. After resection, small incision was made...
Abstract Background: Dedicated breast positron emission tomography (DbPET)provides detailed high resolution images of the and enables quantitative assessment using standard uptake values (SUVs). We aimed to determine whether DbPET can predict pathological malignancy grade neoplastic progress cancer compared with whole body (WB) PET. Methods: investigated 196 consecutive patients invasive cancerwho underwent concurrent Db- WB-PET from January 2016 March 2017. All were quantified based on...
Abstract Background: Whole body (WB) 18F-fluorodeoxyglucose positron emission tomography (PET) has a relatively poor spatial resolution (&gt;1 cm), which limits the capability to detect small lesions. Therefore, small-sized breast cancers (≤1 cm) may not be visible on WBPET. To overcome these limitations, dedicated PET (DbPET) been developed improve resolution. DbPET enables detailed high-resolution images within breast. We aimed determine whether can cancer compared Methods:...
Background: FDG uptake on PET is related to biological parameters and prognosis in breast cancer. The predominance of stromal tumor-infiltrating lymphocytes (TILs) cancer a biomarker for pathological complete response after neoadjuvant chemotherapy. However, whether whole-body (WBPET) dedicated (DbPET) can reflect the amount TILs unclear. This study investigated relationship between maximum standardized value (SUVmax) WBPET ring-type DbPET. Methods: A total 125 invasive cancers underwent...
Abstract Background: Microwave breast imaging, which using the difference in dielectric properties between cancer and normal tissue, is a painless non-radiation method. We have created novel hand-held prototype of detector impulse-radar based imaging system, conducted pilot clinical study. Methods: The consists complementary metal-oxide-semiconductor (CMOS) integrated circuits covering ultrawideband width from 3.1 to 10.6 GHz, enable generation transmission Gaussian monocycle pulse (GMP)...
Abstract Background: Neoadjuvant chemotherapy (NAC) is a standard treatment for operable breast cancer. However, imaging methods evaluating response have not been established. Previous studies reported that ring-type dedicated positron emission tomography (DbPET) detected residual tumors following NAC more accurately than whole-body PET/CT. This study assessed DbPET parameters predicting pathological complete (pCR) in patients with Patients and Methods: Among cancer who underwent surgery...
わが国における検診受診率はまだ低い。また，生理的な症状を主訴とする人や検診対象ではない若年受診者が多く，‘乳房の発達に伴う症状’や‘乳がんの正しい知識’について，第二次性徴が遂げられる時期に正しい知識を身につけるべきと考えた。当科を中心とした「広島乳腺女性医師の会」で企画し，乳腺専門の女性医師たちが市内の女子高校生を対象とした『乳房と乳がんに関する出張講義』を提案，２０１６年１０月～２０１８年１０月までに６校の女子高校，２校の女子大学で延べ１１回，約２，８００人に講義，聴講した生徒を対象に授業後のアンケート調査を実施し，内容に関する理解度や関心度，身近な人の検診受診状況について調査した。アンケート解析の結果，講義内容の理解度は良好で多くの生徒が『自己チェックや検診の必要性を感じ周囲の人にも勧めたい』と回答した。われわれが行っている講義は『がん教育』と『性教育』の二面性を有しており，性教育の一環として第二次性徴を経て獲得する成熟した乳房について正しく理解するとともに，女性で最も罹患率の高い乳がんと検診について関心を持ち，正しい知識を獲得することを目標とする。高校生へのこうした講義は...
Abstract Background Tumor-infiltrating lymphocytes (TILs) in breast cancer comprise immunostimulating and immunosuppressive components. Although FOXP3+ TILs are prototypical TILs, only effector regulatory T cells (eTreg), a subset of undetectable on immunohistochemical staining. This study aimed to evaluate the potential eTregs role immunostimulatory CD8+ invasive cancer. Methods Fresh extracted from 84 patients were analyzed via flow cytometry. We evaluated (CD4+FOXP3highCD45RA−), other...