A5061573586- Metastasis and carcinoma case studies
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Advancements in Battery Materials
- Breast Lesions and Carcinomas
- Moyamoya disease diagnosis and treatment
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Breast Cancer Treatment Studies
- Tracheal and airway disorders
- HER2/EGFR in Cancer Research
- Salivary Gland Tumors Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Cancer and Skin Lesions
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
Hiroshima City Asa Citizens Hospital
2016-2025
Saitama Medical University
2024
North Medical Center
2022-2024
Citizens Specialty Hospitals
2024
Tokyo Metropolitan Institute of Gerontology
2023-2024
Samsung Medical Center
2023
Sungkyunkwan University
2023
Sapporo Kosei General Hospital
2022
Hokkaido University of Science
2022
Kaneka (United States)
2020
Background and Purpose- The clinical significance of vessel wall imaging (VWI) remains unclear in patients with unruptured intracranial aneurysms. This study was performed to investigate the correlations between aneurysm findings histopathologic architectures. Methods- A total 9 aneurysms evaluated by VWI subsequently characterized histopathology. We used visualize determine if there enhancement after gadolinium contrast administration. Results- Aneurysm structures were identified 6 native...
Abstract Regenerating islet‐derived family, member 4 (Reg IV) is a candidate marker for cancer and inflammatory bowel disease. In the present study, immunohistochemical analysis of Reg IV was performed in various human neoplastic ( n = 289) non‐neoplastic tissues. stomach, foveolar epithelium negative IV, whereas goblet cells intestinal metaplasia neuroendocrine at base expressed IV. Neuroendocrine small intestine colon showed strong expression weak or no Insulin‐producing beta endocrine...
Background and Purpose- Unruptured intracranial aneurysms (UIAs) have various scenarios of growth rupture. Magnetic resonance vessel wall imaging can detect aneurysmal thickening with inflammation neovascularization. This study was performed to explore the findings UIAs consecutive follow-up. Methods- A total 60 serial angiography over 2 years (mean period, 49 months, range, 24-192 months) were evaluated by imaging. morphologically categorized into 3 patterns: stable, whole sac expansion, or...
The migration of lithium (Li) ions in electrode materials is an important factor affecting the rate performance rechargeable Li ion batteries. We have examined spinels LiMn(2)O(4), LiCo(2)O(4), and LiCo(1/16)Mn(15/16)O(4) by means first-principles calculations based on density functional theory (DFT). results showed that trajectory jump was straight between two adjacent for all three spinel compounds. However, there were significant differences energy profiles path LiMn(2)O(4) LiCo(2)O(4)....
Posttranslational histone modifications are important for the regulation of many biological phenomena. Here, we show purification and characterization nucleosomal kinase-1 (NHK-1). NHK-1 has a high affinity chromatin phosphorylates novel site, Thr 119, at C terminus H2A. Notably, specifically H2A, but not free H2A in solution. In Drosophila embryos, phosphorylated 119 is found chromatin, soluble core pool. Immunostaining revealed that it goes to during mitosis excluded from S phase....
Aims: The differential diagnosis of pleural sarcomatoid mesothelioma (SM) from lung carcinoma (LSC) invading parietal pleura and chest wall is a challenging issue. aim this study was to identify useful antibodies that can be used for the SM LSC. Methods results: Forty‐five cases 27 LSC were immunohistochemically analysed by using 15 commercially available antibodies, including D2‐40 calretinin, thrombomodulin, Wilms’ Tumour 1, carcinoembryonic antigen (CEA), Napsin A, thyroid transcription...
There are a number of reports indicating that <i>CYP2B6</i>*<i>6</i> (c.516G>T and c.785A>G) is responsible for decreased clearance efavirenz (EFV), although increased disposition cyclophosphamide (CPA) in individuals with this polymorphism was observed. Thus, we hypothesized the effects two single nucleotide polymorphisms (SNPs) on metabolism drugs might be considerably different between these agents. To clarify possibility, expressed major variants enzyme, CYP2B6.6 (Q172H K262R)...
To determine the clinical outcomes of endoscopic submucosal dissection (ESD) for colorectal tumors in older patients and predictors mortality. We retrospectively evaluated 207 lesions 195 consecutive aged ≥ 75 years who underwent ESD between January 2007 December 2018. Outcomes were evaluated, prognosis was assessed terms both curability patient's baseline physical condition as determined by several indices. Cox regression analyses performed to identify factors associated with reduced...
The objective of the present study was to 4 recently encountered ovarian large-cell neuroendocrine carcinoma (LCNEC) cases, and evaluate their clinicopathological features in context previously reported 29 LCNEC cases. First, we described clinical Routine H&E staining immunohistochemistry for CD56, synaptophysin chromogranin A were performed on sections both epithelial components. Clinical data total 33 cases summarized, Kaplan-Meier survival curve estimated. Our observed women aged 42-81...
Most cancer cells have mutations in genes at the G1 checkpoint and repair DNA only G2 phase; therefore, is a potential target to develop novel therapy. In course of screening, known compound, pycnidione, was isolated from fungal culture broth Gloeotinia sp. FKI-3416. Pycnidione irreversibly abrogated bleomycin-induced arrest Jurkat synergically potentiated cytotoxicity bleomycin. To elucidate mechanism action, effect pycnidione on signal transduction analyzed, showing that increased...
Abstract Aim This study aimed to evaluate the risk classification system using detailed positive surgical margin (PSM) status predict biochemical recurrence (BCR) after robot‐assisted radical prostatectomy (RARP). Methods We retrospectively analyzed 427 patients who underwent RARP between January 2016 and March 2020. investigated factors for BCR univariate multivariate Cox proportional hazard regression models. The recurrence‐free survival (BRFS) rate was assessed Kaplan‐Meier method....
Carcinosarcoma of the esophagus is a rare tumor with distinct pathological entity having squamous cell carcinoma as most described carcinomatous component. This paper reports first case carcinosarcoma that showed predominant basaloid component in addition to and poorly differentiated sarcoma A 64‐year‐old male patient consulted for dysphasia chest pain was examined found have gastrointestinal fiber‐endoscope polypoid growth lower third esophagus. Partial esophagectomy performed excised...
Invasion to lymphatic vessels and metastasis lymph nodes are frequent complications in invasive micropapillary carcinoma (IMPC) of human breast cancer. Vascular endothelial growth factor‐C (VEGF‐C) its receptor, VEGFR‐3 have been implicated as the important factors formation recent experimental evidence strongly suggests that lymphangiogenesis tumor promotes metastasis. To clarify mechanism occurrence, expression VEGF‐C, vessel density (LVD) was examined 40 cases IMPC (pure mixed type)...
Objectives The objective of this study was to compare the sensitivity detection lung nodules on low-dose screening CT images between radiologists and technologists. Methods 11 10 technologists read 78 subjects. On with a slice thickness 5 mm, there were 60 that ≥5 mm in diameter: 26 pure ground-glass opacity (GGO), 7 mixed (GGO solid component) 27 nodules. 2 69 35 GGOs, GGOs 21 observers 5-mm at first; then, 6 months later, they 2-mm from Results differences mean sensitivities not...