A5056322048- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- MicroRNA in disease regulation
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Telomeres, Telomerase, and Senescence
- Management of metastatic bone disease
- Advances in Oncology and Radiotherapy
- Brain Metastases and Treatment
- Circular RNAs in diseases
- Cancer and Skin Lesions
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Photodynamic Therapy Research Studies
National Hospital Organization Kyushu Cancer Center
2013-2025
Hiroshima General Hospital
2020-2022
University Malaya Medical Centre
2022
Hiroshima University
2018-2020
Emerging evidence indicates that small RNAs, including microRNAs (miRNAs) and their isoforms (isomiRs), transfer RNA fragments (tRFs), are differently expressed in breast cancer (BC) can be detected blood circulation. Circulating RNAs extracellular vesicles (EVs) have emerged as ideal markers RNA-based applications for detection. In this study, we first undertook sequencing to assess the expression of circulating serum BC patients cancer-free individuals (controls). Expression 3 namely...
e12517 Background: Lymphovascular invasion (LVI) has historically been considered a poor prognostic factor in breast cancer. However, the clinical impact of LVI on cancer prognosis not fully investigated recent era, when concept tumor subtypes and application multigene assays determining adjuvant therapy are well established. Methods: A total 1340 patients with pT1-2N0M0 (pStage I-IIA) were included, who underwent surgery without neoadjuvant systemic between 2010 2020. The relationships Ly...
We present a unique case of metastatic metaplastic breast carcinoma responding dramatically to immunochemotherapy. A 46-year-old Japanese woman with primary the breast, which was immunohistochemically confirmed be triple-negative cancer, underwent radical surgery, followed by adjuvant chemotherapy an anthracycline and taxane. Since multiple lung metastases were detected two months post-chemotherapy site shown PD-L1-positive, immune checkpoint inhibitor (ICI) pembrolizumab plus...
Several studies have recently reported that the relationships between serum vitamin D and prognosis or pathological response to neoadjuvant chemotherapy (NAC) in breast cancer. However, there are no data regarding clinical impacts of Japanese cancer patients so far.In present study, a total 250 with Stage I-III primary who were treated NAC subsequently underwent definitive surgery included. Serum 25-hydroxvitamin (25(OH)D) levels evaluated using blood samples obtained before NAC.The 25(OH)D...
Distant metastases from lung cancer are commonly found in the brain, bone, and liver. Metastases to breast non-mammary malignancies extremely rare, their clinical presentations remain unclear. We herein report a case of bilateral anaplastic lymphoma kinase-positive advanced 51-year-old Japanese male patient. During course systemic treatment for cancer, computed tomography revealed enlargement without contrast enhancement, finding consistent with gynecomastia. While other metastatic lesions...
Abstract Background Clinical Treatment Score post-5 years (CTS5) is a promising prognostic tool to evaluate late distant recurrence (DR) risk for breast cancer after 5-year adjuvant endocrine therapy. Patients and methods Among 560 postmenopausal women with pathological stage I–III estrogen receptor-positive (ER+) primary cancer, 383 who had received therapy without any at 5 surgery were included in this study. The CTS5 was calculated each patient using previously published formula, the...
Abstract Background Spontaneous regression (SR) is a rare phenomenon in which cancer disappears or remits without treatment. We report case of breast that showed spontaneous tumor the surgical specimen after core needle biopsy. Case presentation A 59-year-old woman came to our hospital complaining painful lump right breast. In upper-outer quadrant breast, with an unclear boundary, 30 mm diameter, was palpable. pathological findings from biopsy, diagnosed as solid-type invasive ductal...
The telomere G-tail (G-tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte length of breast cancer (BC) patients and cancer-free individuals evaluated association between presence BC. A significant shortening median was observed BC compared with found early phase Our study indicated that might be a potential biomarker for detection.
Background: Previous studies have suggested that the presence of visceral metastasis is a parameter useful in predicting treatment efficacy fulvestrant patients with advanced breast cancer. Patients and Methods: We retrospectively examined association between 75 hormone receptor-positive recurrent cancer who were treated or no more than five lines other endocrine monotherapy after recurrence. Results: Nineteen received fulvestrant, 10 whom had metastasis. The median time to progression was 4...
Distant metastases from breast cancer are frequently found in bones, lungs and the liver. Metastasis to stomach is rare, its clinical presentation remains unclear. The present report describes a case of isolated gastric metastasis identified by contrast-enhanced computed tomography (CT). A 45-year-old female patient underwent right mastectomy axillary lymph node dissection after preoperative chemotherapy for invasive lobular carcinoma T4bN2M0, stage IIIB. Postoperative radiotherapy endocrine...
Carbohydrate antigen 15-3 (CA 15-3) is known as a specific tumor marker for breast cancer, the main use of which monitoring therapy in patients with advanced cancer. Either systemic sclerosis (SSc)-interstitial lung disease (ILD) or pulmonary arterial hypertension currently leading cause disease-related morbidity and mortality scleroderma. Although CA has been investigated biomarker SSc-ILD, its role remains unclear. The current report presented case recurrent cancer diagnosed SSc-ILD during...
Annotating genomic sequence alterations is sometimes a difficult decision, particularly in missense variants with uncertain pathogenic significance and also those presumed as germline variants. We here suggest that mutation spectrum may be useful for judging them. From the public databases, 982 BRCA1/1861 BRCA2 294 BRCA1/420 somatic were obtained. then compared their spectra, i.e., frequencies of two transition- four transversion-type mutations, each category. Intriguingly, BRCA1 variants,...
Microsatellite instability (MSI) is now widely used as an indispensable biomarker. However, the relationship between MSI-H (high) and defective DNA mismatch repair (MMR) not straightforward has been expected. Genome-edited cells carrying Lynch syndrome mutations do exhibit drastic MSI typical in (i.e. Type B) but more subtle A). In this study, we explored a connection A 5-fluorouracil (5-FU) resistance colorectal cancer patients. Using our precision high-resolution assay technique, tumour...
Oncocytic carcinoma of the breast is rare and its molecular profiles remain poorly understood. MicroRNAs (miRNAs/miRs) have been identified as contributors to carcinogenesis at post-transcriptional level; thus, an aberrant expression miRNAs has attracted attention a potential biomarker numerous diseases, including cancer. The present study reports case 76-year-old woman diagnosed with oncocytic breast. Considering distinctive feature breast, which presence granular eosinophilic cytoplasm...
Abstract Background A non-luminal disease score (NOLUS) is pathology-based predictive model to identify PAM50 within HR+/HER2-negative breast cancer. NOLUS a new model, therefore, its clinical utility not sufficiently elucidated. In this study, the impact of was investigated in unresectable/metastatic estrogen receptor (ER) positive (ER+)/HER2-negative Patients and Methods The total 61 patients, who were diagnosed ER+/HER2-negative cancer between 2010 Apr 2023, included study. status...
Abstract Background Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare malignancy. Many cases of BIA-ALCL are identified based on the presence late-onset effusion and/or masses. Importantly, United States Food and Drug Administration noted that in all diagnosed patients with textured implants, either had history mixed implantation smooth devices or no clinical was supplied for review. In Japan, first case reported 2019, we encountered third Japan December 2021....