A5007364963- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Dental Health and Care Utilization
- Oral Health Pathology and Treatment
- Endodontics and Root Canal Treatments
- HIV/AIDS oral health manifestations
- Dental Research and COVID-19
- Advanced Chemical Sensor Technologies
- Dental materials and restorations
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Salivary Gland Disorders and Functions
- Immune Response and Inflammation
- Parvovirus B19 Infection Studies
- Dental Trauma and Treatments
- Oral health in cancer treatment
- Autophagy in Disease and Therapy
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Virology and Viral Diseases
- Rabies epidemiology and control
Hiroshima University
2004-2025
The associations between oral human herpesvirus-6 (HHV-6) and HHV-7, periodontal conditions, lifestyle-related diseases, such as hypertension, diabetes, dyslipidemia, have not been fully investigated in older adults.Seventy-four patients who visited Hiroshima University Hospital were enrolled. Tongue swab samples employed, a real-time polymerase chain reaction was performed to detect HHV-6 HHV-7 DNA. Dental plaque accumulation, probing pocket depth, bleeding on (BOP) (i.e., sign of...
Abstract Objectives For people, it is challenging to be conscious of the appropriate toothbrushing time maintain good oral health in daily life. The aim this study was preliminarily examine utility an application (app) that combines a timer and information on toothbrushes. Materials Methods We developed “Toothbrushing Timer with Information Toothbrushes” app help users ensure learn about beneficial characteristics A total 18 participants were registered for study. At baseline (T0) after 1...
Abstract Objective The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer. Subjects Methods This retrospective cohort analyzed data from 140 cancer who underwent surgery at Hiroshima University Hospital May 2019 2022. Periodontal inflamed surface area (PISA) scores were determined assess severity using modified Nesse's methods. Propensity score matching used compare high low PISA...
ABSTRACT Objective Cigarette smoking is associated with oral disease, whereas cigarette smoke extract (CSE) an aqueous solution containing most of the compounds and toxins inhaled by smokers. Although it has been reported that CSE directly affected dysfunctions in examinations various cell cultures, its effects on immune response to bacterial components keratinocytes remain largely unknown. The present study investigated chemokine expression induced Pam3CSK4 (Pam3), a mimic lipopeptide....
Background/Objectives: Nisin A, an antimicrobial peptide produced by Lactococcus lactis, primarily shows activity against Gram-positive bacteria, with efficacy increased when used in combination drug. On the other hand, oral candidiasis, caused Candida, occurs immunocompromised patients and requires antifungal therapy. However, drug-resistant Candida strains are increasing worldwide, leading to serious problems. Methods: To examine effects of nisin A species, we investigated combined drugs...
<em>Capnocytophaga</em> species are commonly found in human oral microbiome. The aim of the present study was to understand association prevalence with hygiene and periodontal inflammation. A total 136 patients (median age 72 years) who visited Hiroshima University Hospital (Hiroshima, Japan) between April 2021 June 2023 were enrolled. Swab samples obtained from tongue surface. DNA (<em>C. ochracea</em> <em>C. sputigena</em>) detected by real‑time PCR analysis. Dental plaque accumulation...
The present preliminary study aimed to investigate the association between oral human papillomavirus type 16 (HPV16) DNA prevalence and periodontal inflammation in older women. HPV16 infection health status has not been fully elucidated Japanese investigated women aged ≥60 years who visited Hiroshima University Hospital. excluded subjects with clinical factors affecting HPV infection, such as current smoking, cancer pre‑malignant lesions, immunodeficiency. Finally, 46 female patients (mean...
The aim of this study was to develop an objective method assess the degree bristle splaying used manual toothbrushes and investigate their plaque removal efficacy.A randomized controlled trial targeting Hiroshima University students performed efficacy polybutylene terephthalate (PBT) toothbrushes. Participants were randomly assigned soft toothbrush group (n = 40) or medium 40). A small number participants discontinued intervention for personal reasons in both 6) 2) groups. Toothbrushes...
The periodontal inflamed surface area (PISA) has been proposed for assessment of the total inflammatory status in people with periodontitis. This study was performed to investigate associations periodontopathic bacteria and candida PISA older people. We enrolled 100 patients aged ≥ 60 years who visited Hiroshima University Hospital. epithelial (PESA) were calculated each patient. Oral rinse samples collected DNA extraction. Periodontopathic detected by polymerase chain reaction. mean values...
Abstract Introduction Slightly acidic electrolyzed water (SAEW) is sterilizing agent produced by the electrolysis of hydrochloric acid. Because SAEW has been applied to various foods as disinfectant, expected be used in medical field. In this study, we evaluated bactericidal effect on oral bacteria. Methodology The activity against cariogenic bacteria, periodontopathogenic and antibiotic‐resistant bacteria was evaluated. Results We first examined Streptococcus mutans UA159 with different...
We previously reported that polybutylene terephthalate (PBT) toothbrushes become less effective for plaque removal after two months of use. However, it remains unknown how the bristle stiffness PBT changes several performed a single-center randomized controlled trial to evaluate and splaying soft medium manual among dental medical students Hiroshima University. Subjects were 80 participants who met criteria. Participants randomly assigned toothbrush group (n = 40) or 40). collected...
The aim of this study is to clarify the deflection, splaying, and abrasion single tufts polybutylene terephthalate (PBT) toothbrushes after use. A single-center randomized controlled trial performed. changes in bristle are investigated for middle tuft top line (top–middle tuft) bottom (bottom–middle PBT with medium stiffness 1 month, 2 months, 3 months use by 34 participants. soft-material bending-resistance tester used assess deflection tufts. value top–middle significantly increased month...
Abstract Aim The involvement of human papillomavirus (HPV) E6/E7 in autophagy has not been fully elucidated oral squamous cell carcinoma (OSCC) cells. objective this study was to clarify the association between HPV and cancer stem properties such as self‐renewal ability chemotherapy resistance HPV16‐positive OSCC Methods UM‐SCC‐104 cells were cultured on laminin 332‐coated silicone gel. impact HPV16 E6 or E7 siRNA transfection proliferation, spheroid formation, 5‐fluorouracil (5‐FU)‐induced...
Abstract Aim This study aimed to investigate the association between presence of oral herpes simplex virus type 1 (HSV‐1) DNA and hygiene condition in dependent older adults. Methods We focused on 45 individuals (11 males 34 females; median age 89 years) with certified needs for long‐term support or nursing care. Real‐time PCR analysis was performed identify HSV‐1 from samples collected tongue surface via swab brushes. Concurrently, detection 16S rRNA gene periodontopathic bacteria such as...
The cover image is based on the Original Article Measurement of bristle splaying toothbrushes using digital imaging and evaluation plaque removal efficacy over 3 months: A randomized controlled trial (RCT) by Hideo Shigeishi et al., https://doi.org/10.1111/idh.12427