A5011937874- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- interferon and immune responses
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- Infective Endocarditis Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Pediatric health and respiratory diseases
- Peptidase Inhibition and Analysis
- Antimicrobial Resistance in Staphylococcus
- Chemokine receptors and signaling
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Salivary Gland Disorders and Functions
- Cardiomyopathy and Myosin Studies
- Pneumonia and Respiratory Infections
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial biofilms and quorum sensing
- Cardiac Valve Diseases and Treatments
Hiroshima University Hospital
2016-2025
Hiroshima University
2004-2025
Fukuoka Higashi Medical Center
2024
Hiroshima Minami High School
2022
Kurume University
1989-1999
Saitama Medical University
1980
An association between moenomycin resistance and vancomycin intermediate in Staphylococcus aureus was demonstrated previously. Thus, to elucidate the mechanism of resistance, we searched for factors contributing resistance. Random Tn551 insertional mutagenesis methicillin-resistant S. strain COL yielded three mutants with decreased susceptibilities moenomycin. Correspondingly, these also exhibited slightly vancomycin. Genetic analysis revealed that two had insertions fmtC (mprF) gene, which...
Summary Glucosamine‐6‐P occupies a central position between cell wall synthesis and glycolysis. In the initial steps leading to peptidoglycan precursor formation glucosamine‐6‐P is processed sequentially UDP‐ N ‐acetylglucosamine, while enter glycolysis pathway, isomerized by NagB fructose‐6‐P. Although we could not demonstrate activity, nagB inactivation significantly reduced growth. Mutational analysis showed that NagA was involved in from ‐acetylglucosamine‐6‐P, GlmS Inactivation of glmS...
ObjectivesThe susceptibility of clinical isolates Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), to host-derived cationic antimicrobial peptides was investigated.
The records of 70 patients with oral cancer who were treated at a single institution between 2008 and 2014 reviewed. body temperature, white blood cell count, C-reactive protein (CRP) levels compared those had received preoperative care (oral group) not any (non-oral group). When the divided into underwent minimally invasive surgery severely surgery, mean CRP level in early postoperative period was lower group as non-oral well surgery. However, most evidently reduced on days 1 3-5. no...
BACKGROUND: Recent studies have indicated an association between periodontitis and atrial fibrillation (AF), although the underlying mechanisms remain unclear. Porphyromonas gingivalis is a causative agent of periodontal disease highly pathogenic. This study focused on P aimed to investigate relationship among periodontitis, translocation , fibrosis AF. METHODS: An experiment was conducted using –infected C57BL/6J mice, in which inoculated into pulp molars. Immunohistochemistry used...
Th1 and Th2 cytokines such as interferon-γ (IFN-γ ) , tumor necrosis factor- α (TNF-α ), IL-4 are expressed in T-cell-mediated inflammation the oral cavity. We tested hypothesis that those may act on CXCR3-agonistic chemokines, T-cell recruiting factors, neighboring cells, including keratinocytes fibroblasts. Human immortalized (RT7) fibroblasts (GT1) after 24-hour stimulation with IFN-γ showed increased mRNA levels of CXCL9 (600- 700-fold), CXCL10 (10,000- 150-fold), CXCL11 (5000-...
Oral keratinocytes and fibroblasts may be the first line of host defense against oral microorganisms. Here, contention that recognize microbial components via Toll-like receptors (TLRs) participate in development inflammation was examined. It found immortalized (RT7), (GT1) primary cells express mRNA TLRs 1-10. Interleukin-8 (IL-8) production by RT7 induced treatment with 1-9 exception TLR7 agonist, whereas GT1 were to produce IL-8 all TLR agonists tested except for TLR9. showed increased...
Abstract Objective The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer. Subjects Methods This retrospective cohort analyzed data from 140 cancer who underwent surgery at Hiroshima University Hospital May 2019 2022. Periodontal inflamed surface area (PISA) scores were determined assess severity using modified Nesse's methods. Propensity score matching used compare high low PISA...
Oral care is crucial for the prevention of cardiovascular events and pneumonia. However, few studies have evaluated associations between multidimensional assessments oral status or functional outcomes hospital-acquired pneumonia (HAP).
Background/Objectives: Nisin A, an antimicrobial peptide produced by Lactococcus lactis, primarily shows activity against Gram-positive bacteria, with efficacy increased when used in combination drug. On the other hand, oral candidiasis, caused Candida, occurs immunocompromised patients and requires antifungal therapy. However, drug-resistant Candida strains are increasing worldwide, leading to serious problems. Methods: To examine effects of nisin A species, we investigated combined drugs...
Acute respiratory failure (ARF) is a severe condition requiring intensive care unit (ICU) admission. Periodontal disease chronic inflammatory disorder caused by periodontal bacteria, though it unknown whether specific bacteria are associated with ARF patients admitted to the ICU. The present study was conducted compare oral environmental factors and numbers of between without related ICU A cross-sectional investigation performed 64 patients, divided into (n=18) non-ARF (n=46) groups based on...
Abstract Objectives Medication-related osteonecrosis of the jaw (MRONJ) caused by bone resorption inhibitors is difficult to treat and reduces patient’s quality life. We aimed classify likelihood MRONJ development using panoramic radiographs taken prior inhibitor administration. Methods included patients who underwent radiographic evaluation at Hiroshima University Hospital Thirty-two with MRON mandible (16 men 16 women) 57 without (23 34 were selected. The was segmented from mental foramen...
Ameloblastoma (AM) shows locally invasive behaviour. However, biological investigations regarding regulation of gene expression associated with AM pathological features are difficult to perform, because cells can be passaged for a few generations due senescence. We report newly established immortalized cell line, AMB cells, by transfection human telomerase reverse transcriptase (hTERT). Furthermore, we examined whether TNF-α modulates bone resorption-related genes, IL-6 and MMP-9 in...
Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be important infection route, it unknown whether environment associated with FN. The present study examined relationship between using periodontal inflamed surface area (PISA), a new disease parameter, and FN in hematologic cancer patients undergoing In this retrospective cohort study, 157 were divided into onset chemotherapy (n = 75) negative groups 82). associations of...
Abstract Purpose Several studies have found associations between periodontitis and various types of cancer. Since the site head neck cancer (HNC) has contiguity or proximity to oral cavity, it may be particularly influenced by inflammation. This study aimed determine whether HNC patients poor health as compared those with other Methods retrospectively examined environmental factors including periodontal inflamed surface area (PISA), a new inflammatory parameter. A total 1030 were divided...
ABSTRACT Oral keratinocytes provide the first line of host defense against oral candidiasis. We speculated that interactions fungal cell wall components with regulate stress response Candida infection and examined expression genes induced by heat-killed albicans in immortalized using a cDNA microarray technique. Of 24,000 revealed analysis, we focused on HO-1, stress-inducible gene, as its was increased both live C. . In histological findings, HO-1 superficial layers epithelium following...
Background: Innate immune response by oral mucosal cells may be the first line of host defense against viral infection. Retinoic acid-inducible gene-I (RIG-I) recognizes dsRNA in cytoplasm, and RIG-I-mediated signaling regulates antiviral type I IFN, inflammatory chemokine production. Here, we tested hypothesis that cell participation infection via RIG-I. Methods: RIG-I expression was detected immortalized keratinocytes (RT7), fibroblasts (GT1) using RT-PCR immunohistochemistry. RT7 GT1 were...
Several cohort studies have shown that periodontal disease is associated with an increased risk for stroke. However, it remains unclear whether serum antibody titers a specific pathogen are outcome after ischemic stroke, and which kinds of pathogens We examined the relationship between IgG to in stroke patients. A total 445 patients acute (194 female [44.0%], mean age 71.9±12.3 years) were registered this study. Serum 9 (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans,...
Abstract Introduction Inflammation is one of the main causes atrial fibrillation (AF) recurrence after ablation. Porphyromonas gingivalis a key periodontal pathogen in oral–systemic disease connection and serum immunoglobulin G (IgG) antibody titers against P. reflect clinical status periodontitis. This study aimed to investigate relationship between late AF radiofrequency catheter ablation (RFCA) IgG . Methods A total 596 patients (mean age, 64.9 ± 10.0 years; 69% male; 61% paroxysmal AF)...