A5054577013- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Oral microbiology and periodontitis research
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Herpesvirus Infections and Treatments
- Folate and B Vitamins Research
- Neurological and metabolic disorders
- Cerebral Venous Sinus Thrombosis
- Otolaryngology and Infectious Diseases
- Virology and Viral Diseases
- Neurological Complications and Syndromes
- Viral Infections and Immunology Research
- Peripheral Neuropathies and Disorders
- Migraine and Headache Studies
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Multiple Sclerosis Research Studies
- Blood Pressure and Hypertension Studies
- Moyamoya disease diagnosis and treatment
- Streptococcal Infections and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Nutrition and Health in Aging
- Peripheral Artery Disease Management
Hiroshima University
2017-2022
Asahikawa Kosei Hospital
2022
Hiroshima International University
2021
Nagoya University
2021
Kure Medical Center
2021
National Hospital Organization
2021
Aichi Medical University
2021
Shiga Medical Center
2016-2019
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2015-2018
Abstract Thus far, it is well known that increased blood pressure variability may exacerbate stroke outcomes. Blood in the acute phase would be influenced by both reactive hypertension to and intrinsic reactivity. Thus, we aimed evaluate association between outcomes at 3 months using ambulatory monitoring ischemic patients subacute after subsided. We retrospectively examined 626 consecutive with who underwent 24-hour during of (median, 9 days from onset). The was evaluated assessing standard...
大建中湯の消化管運動に対する作用およびイレウス治療に対する有用性について検討した. 方法: 意識下の雑種成犬4頭を用いて, 大建中湯投与前後の消化管運動をstrain gauge transducer法により測定した. さらに, xylocaineにより胃粘膜を麻酔した後に同量の大建中湯を投与した. 臨床的検討として, イレウスにて入院となった患者の在院日数を大建中湯投与群と非投与群で比較検討した. 結果: 大建中湯の投与後, 胃, 十二指腸, 空腸および回腸の運動亢進が観察された. 胃粘膜麻酔後には, これらの消化管運動亢進作用はまったく認められなかった. 臨床的検討では, 大建中湯投与群の在院日数は21.8±2.4日で非投与群は, 27.7±2.9日で両群間に有意の差を認めた. 結論: 大建中湯は, 粘膜刺激を介して, 強い上部消化管運動亢進作用を有する. この大建中湯の薬理作用および作用機序は, 臨床的にイレウス治療に対して十分応用価値があるものと考えられた.
The prediction of functional outcome is essential in the management acute ischemic stroke patients. We aimed to explore various prognostic factors with multivariate linear discriminant analysis or neural network and evaluate associations between candidate factors, baseline characteristics, outcome.Acute patients (n=1,916) premorbid modified Rankin Scale (mRS) scores 0-2 were analyzed. models (quantification theory type II) (log-linearized Gaussian mixture network) used predict poor (mRS 3-6...
Several cohort studies have shown that periodontal disease is associated with an increased risk for stroke. However, it remains unclear whether serum antibody titers a specific pathogen are outcome after ischemic stroke, and which kinds of pathogens We examined the relationship between IgG to in stroke patients. A total 445 patients acute (194 female [44.0%], mean age 71.9±12.3 years) were registered this study. Serum 9 (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans,...
Stroke can be a cause of death, while in non-fatal cases it is common various disabilities resulting from associated brain damage. However, whether specific periodontal pathogen with increased risk unfavorable outcome after stroke remains unknown. We examined factors for following occurrence, including serum antibody titers to pathogens. The enrolled cohort included 534 patients who had experienced an acute stroke, were divided into favorable (n = 337) and 197) groups according modified...
Oral health conditions and cerebral small vessel disease, such as white matter lesions or microbleeds (CMBs), are associated with the incidence of stroke. The purpose this study was to examine associations between oral (serum IgG titers periodontal pathogens) presence severity CMBs in acute stroke patients. From January 2013 April 2016, patients were registered two hospitals. Serum samples evaluated for antibody against 9 pathogens using ELISA method. cut-off points reactivity (the positive...
2004年~2016年で成人無菌性髄膜炎437例中,水痘・帯状疱疹ウイルス(varicella zoster virus; VZV)髄膜炎は11例(52.7 ± 14.9歳,すべて男性),頻度は2.5%であった.夏~秋に多く地区の水痘の流行と鏡像的であった.9例は髄液中VZV-DNA陽性,2例はVZV-IgG抗体価指数2以上で診断した.発症7日頃までは前者,以後は後者が有用であった.8例は帯状疱疹が先行,1例は髄膜炎が先行,2例は皮疹を認めなかった.2例はB型肝炎キャリアー,1例はインフルエンザワクチン注射後,1例がステロイド内服中であった.神経合併は三叉神経痛,顔面神経麻痺,舌咽神経痛,Elsberg症候群など認め重症化する症例もあった.
Neuronal intranuclear inclusion disease (NIID) is a slowly progressive neurodegenerative disorder with wide range of clinical manifestations, including dementia and peripheral neuropathy.1 NIID pathologically characterized by eosinophilic hyaline inclusions found in the central nervous systems various organs, skin,1,2 which enables confirmation diagnosis skin biopsy.2 High-intensity signals along corticomedullary junction on diffusion-weighted imaging (DWI) bilateral leukoencephalopathy are...
症例は69歳の男性である.入院10日前頃から左下肢に帯状疱疹(herpes zoster; HZ)が出現し,その後四肢痙性運動不全麻痺を発症した.皮疹は左腰髄L2~4領域と全身にも散在していた.脊髄MRIで延髄下端~胸髄Th2の長軸に長いT2強調像で高信号病巣を示した.髄液蛋白増加,リンパ球優位の細胞増加を示し,水痘・帯状疱疹ウイルス(varicella-zoster virus; VZV)DNAが陽性であった.血清抗myelin oligodendrocyte glycoprotein(MOG)抗体が陽性で抗aquaporin4抗体は陰性であった.肺炎と肝障害も認め,皮疹の状況から汎発性HZと思われた.HZが引き金となり,抗MOG抗体が産生されて,脊髄炎が発症した病態が推察された.
Serum 1,5-anhydroglucitol (1,5-AG) levels are a measure that provides information on daily glycemic variations. We evaluated whether 1,5-AG could be possible marker of acute ischemic stroke (AIS) or transient attacks (TIA) in patients with diabetes mellitus (DM).We retrospectively reviewed electronic medical records 5,294 AIS/TIA patients. Of the 5,294, 1,898 had and 1,246, serum were measured (group S). Group S was divided into 2 subgroups: hemoglobin A1c (HbA1c) <7% (S-low) >7% (S-high)....
2004年~2014年で,成人無菌性髄膜炎365例中,ムンプス髄膜炎は13例(3.6%,29.8 ± 7.0歳)であった.季節性はないが,地区のムンプス流行に一致した発症率であった.耳下腺腫脹は8例(61.5%),精巣炎は男性7例中2例(28.6%)に認めた.重症度,転機を含めエコーウイルス髄膜炎に類似するが,髄液の単核球比率が高かった.発症前にムンプス患者との接触は8例(61.5%),ワクチン接種は1例,非接種9例,3例は確認できなかった.抗ムンプス抗体価から判断して,6例は初感染,2例は再感染が疑われ,初感染の高齢化が認められた.ワクチン接種歴のある症例は二次性ワクチン不全と思われた.
症例は53歳の女性である．不眠とうつ病で発症し，進行性認知機能低下，具体的な幻視，パーキンソン症状，イオフルパンSPECTで線条体への著明な集積低下，IMP-SPECTで後頭葉の脳血流低下などを認め，レヴィ小体型認知症（dementia with Lewy bodies; DLB）と診断した．亜急性に舌突出と咬舌が出現し救急入院した．レボドパ，ロチゴチン，ロピニロールの高容量投与で，ドパミンD1受容体が長期に刺激状態で，急激な増量で生じた舌ジストニアと診断した．また声門閉鎖を伴う喉頭ジスキネジアによる呼吸困難も出現した．抗精神病薬による薬剤過敏性およびレボドパ過剰投与などが関連した病態と推定され，致死的にもいたる症例であった．
Wall shear stress (WSS) is the frictional force caused by viscous blood flowing along vessel wall. Decreased WSS associated with local vascular endothelial dysfunction and atherosclerosis. The vector flow mapping (VFM) technique detects direction of intracardiac on wall echocardiography. In this study, we examined carotid applying VFM to arteries evaluated its relationship cerebral small disease (SVD).This a single-center, prospective, observational study. We investigated association between...
To assess the influence of periodontal disease on cerebral hemorrhage and its clinical course, we examined association serum IgG titer pathogens with growth 3-month outcome. We consecutively enrolled 115 patients acute (44 females, aged 71.3 ± 13.1 years) used ELISA to evaluate titers 9 pathogens: Porphyromonas gingivalis, Aggregatibacter (A.) actinomycetemcomitans, Prevotella intermedia, nigrescens, Fusobacterium (F.) nucleatum, Treponema denticola, Tannerella forsythensis, Campylobacter...
症例は63歳の男性である.痙攣で発症した上矢状静脈洞の血栓症で,著明な高ホモシステイン血症(93.5 nmol/ml)を合併していた.葉酸とビタミンB12の複合欠乏が認められ,メチレンテトラヒドロ葉酸還元酵素遺伝子C677T変異はT/T型であった.葉酸の単独投与により増加部分の86%が低下し,ビタミンB12の追加投与により4ヶ月で正常値に改善した.高ホモシステイン血症の原因は葉酸欠乏が主である事が確認された.ビタミン欠乏など後天的要因でもホモシステインは3桁近くまで異常増加することが明らかになった.矯正可能な危険因子として,高ホモシステイン血症は重要であり,関連するビタミンの検査が必須である.
可逆性脳血管攣縮症候群(reversible cerebral vasoconstriction syndrome; RCVS)11例を報告する.男性2例,女性9例で平均年齢47.9 ± 14.1歳で若年者に多かった.雷鳴頭痛と言える強度の頭痛は64%,全身けいれん27%,運動麻痺36%であった.脳内病変の合併は,脳表限局のくも膜下出血63%,皮質下出血9%,可逆性後頭葉白質脳症45%で発症初期から認めた.脳梗塞は45%に,発症後1~3週間目頃に起った.脳血管攣縮は発症1ヶ月目頃から改善傾向を認めた.誘因は,産褥,片頭痛既往,輸血,急速な貧血改善,腎不全,入浴,脳血管解離の合併などが認められた.発症時の血圧異常高値を55%に認めたが,誘因なのかは確定的ではなかった.
Strains of Streptococcus mutans expressing the cell surface collagen-binding protein, Cnm, encoded by cnm (cnm-positive S. mutans), are associated with hypertensive intracerebral hemorrhage (ICH) and occurrence cerebral microbleeds (CMBs). Small diffusion-weighted imaging (DWI) hyperintensities in patients acute ICH also CMBs. However, association between cnm-positive DWI is unclear. Hence, this study aimed to investigate ICH.Patients were prospectively registered at three hospitals. Dental...