A5022933221- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Oral microbiology and periodontitis research
- X-ray Diffraction in Crystallography
- Atrial Fibrillation Management and Outcomes
- Crystallization and Solubility Studies
- Lipoproteins and Cardiovascular Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
- Climate Change and Health Impacts
- Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Neurosurgical Procedures and Complications
- Botulinum Toxin and Related Neurological Disorders
- Thermoregulation and physiological responses
- Parkinson's Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vagus Nerve Stimulation Research
Hiroshima University
2016-2025
Psychiatric Rehabilitation Association
2024
Japan Society for the Promotion of Science
2024
Hiroshima University Hospital
2017-2023
National Cerebral and Cardiovascular Center
2010-2022
National Hospital Organization
2011-2021
Aichi Medical University
2021
Nagoya University
2021
Kure Medical Center
2021
Hiroshima International University
2021
BackgroundAlthough statin therapy is beneficial for the prevention of initial stroke, benefit recurrent stroke and its subtypes remains to be determined in Asian, whom profiles are different from Caucasian. This study examined whether treatment with low-dose pravastatin prevents recurrence ischemic patients.MethodsThis a multicenter, randomized, open-label, blinded-endpoint, parallel-group patients who experienced non-cardioembolic stroke. All had total cholesterol level between 4.65 6.21...
Synthetic magnetic resonance imaging (MRI) is an innovative MRI technology that enables the acquisition of multiple quantitative values, including T1 and T2 proton density, myelin volume, in a single scan. Although usefulness measurement with synthetic has been reported for assessing several diseases, investigations patients stroke have not reported. We aimed to explore utility quantification using predicting outcomes acute ischemic stroke. Patients (n=101) premorbid modified Rankin Scale...
Background and Purpose— Alberta Stroke Programme Early CT Score (ASPECTS) is a quantitative topographical score to evaluate early ischemic change in the middle cerebral arterial territory on as well diffusion-weighted imaging (DWI). The aim of present study was elucidate relationship between CT-ASPECTS DWI-ASPECTS for patients with hyperacute stroke their associations outcomes after recombinant tissue-type plasminogen activator therapy based multicenter registry. Methods— ASPECTS assessed...
<b>Objective:</b> To evaluate whether the pretreatment Alberta Stroke Programme Early CT Score (ASPECTS) assessed using diffusion-weighted imaging (DWI) predicts stroke outcomes at 3 months following IV recombinant tissue-type plasminogen activator (rt-PA) therapy. <b>Methods:</b> patients treated with rt-PA (0.6 mg/kg alteplase) in 10 centers Japan were retrospectively studied. ASPECTS was on DWI just prior to injection. The primary outcome a modified Rankin Scale (mRS) score of 0–2 months....
<b><i>Background:</i></b> Periodontitis increases the risk of atherosclerotic cardiovascular disease and ischemic stroke. In this study, we evaluated whether serum antibody levels against individual periodontal pathogens are significantly associated with stroke subtypes their factors. <b><i>Methods:</i></b> Patients acute (n = 132; 74 male 58 female, 71.3 ± 10.7 years) patients no previous 77; 38 39 70.7 9.5 were consecutively enrolled in...
Dysphagia occurs in acute stroke patients at high rates, and many of them develop aspiration pneumonia. Team approaches with the cooperation various professionals have power to improve quality medical care, utilizing specialized knowledge skills each professional. In our hospital, a multidisciplinary participatory swallowing team was organized. The aim this study clarify influence approach on dysphagia by comparing rates pneumonia prior post organization. All consecutive who were admitted...
The magnitude of the CHA2DS2-VASc score is associated with not only stroke incidence but also long-term outcomes. association between sex and initial severity in AF-related cardioembolic patients has been clarified. present study aimed to elucidate risk factors for among enrolled a multicenter registry.We selected 12,701 (age, 77±10 years; 5,653 women) from Japan Standard Stroke Registry Study January 2000 July 2013. Indicators National Institutes Health Scale (NIHSS) scores at admission...
Oral care is crucial for the prevention of cardiovascular events and pneumonia. However, few studies have evaluated associations between multidimensional assessments oral status or functional outcomes hospital-acquired pneumonia (HAP).
There may be ethnic differences in carotid atherosclerosis and its contributing factors between Asian other populations. The purpose of this study was to examine intima-media complex thickness (IMT) the artery associated clinical Japanese stroke patients with hyperlipidemia from a cohort Japan Statin Treatment Against Recurrent Stroke Echo Study.Patients hyperlipidemia, not on statins, who developed noncardioembolic ischemic were included study. Mean IMT maximum distal wall common centrally...
Abstract Thus far, it is well known that increased blood pressure variability may exacerbate stroke outcomes. Blood in the acute phase would be influenced by both reactive hypertension to and intrinsic reactivity. Thus, we aimed evaluate association between outcomes at 3 months using ambulatory monitoring ischemic patients subacute after subsided. We retrospectively examined 626 consecutive with who underwent 24-hour during of (median, 9 days from onset). The was evaluated assessing standard...
Background and purpose The present study clarifies associations between stroke outcomes after intravenous tissue plasminogen activator (tPA) blood pressure (BP) as well heart rate (HR) profiles. Methods We assessed 125 patients with who received tPA within 3 h of onset. obtained baseline, mean, maximum, minimum, coefficient variation values for BP HR during the initial 24 h. primary outcome was independence at months corresponding to a modified Rankin Scale score 2 or less. secondary were...
Limited evidence exists on the relationships between severity of white-matter lesions (WMLs) and cerebral hemodynamics in patients without major artery disease. To examine changes blood flow (CBF), oxygen metabolism, vascular reserve capacity associated with WML lacunar stroke, we used a positron emission tomography (PET). Eighteen were divided into two groups according to WMLs, assessed by Fazekas classification; grades 0 1 as mild group 2 3 severe group. Rapid dual autoradiography was...
Alpha-2-macroglobulin (α2MG) is thought to be associated with inflammatory reactions and procoagulant properties that might cause ischemic stroke. Endothelial dysfunction plays an important role in atherosclerosis development the occurrence of cardiovascular events. In this study, we investigated whether serum α2MG levels, endothelial function, progenitor cell (EPC) number were patients chronic stroke or risk factors.Patients a history any established factors enrolled study (n=102; 69 men,...
Background and Purpose— To define desirable target low-density lipoprotein (LDL) cholesterol levels for the prevention of stroke recurrence, a post hoc analysis was performed in J-STARS study (Japan Statin Treatment Against Recurrent Stroke). Methods— Subjects (n=1578) were divided into groups based on mean value postrandomized LDL until last observation 20 mg/dL increments. Adjusted hazard ratios (HRs) 95% confidence intervals analyzed each group, with adjustments baseline cholesterol, body...
Brain infarct patterns that are observed via diffusion-weighted imaging useful for classifying stroke subtypes. However, it is unclear whether can predict long-term outcomes in cryptogenic patients. Herein, we investigated the association between acute brain and patients.Acute patients were consecutively enrolled April 2008 March 2012. Diffusion-weighted ischemic lesion classified as single lesions, scattered lesions one vascular territory, or multiple territories. Survivors (at discharge)...
We hypothesized that meteorological conditions on the onset day and former days may play important roles in modulation of physical conditions. Associations factors their changes with stroke are interest. conducted a multicenter retrospective study to evaluate frequency events interaction daily changes. Acute patients (n = 3935, 73.5±12.4 years, 1610 females) who were admitted 7 hospitals three restricted areas enrolled this study. Poisson regression models involving time-lag variables was...