A5111851718- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Stroke Rehabilitation and Recovery
- Viral gastroenteritis research and epidemiology
- Pulsars and Gravitational Waves Research
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Intracranial Aneurysms: Treatment and Complications
- Tactile and Sensory Interactions
- Microbial Natural Products and Biosynthesis
- Science Education and Perceptions
- Animal Virus Infections Studies
- Plant Pathogens and Fungal Diseases
- Moyamoya disease diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Gamma-ray bursts and supernovae
- Genomics and Phylogenetic Studies
- Enterobacteriaceae and Cronobacter Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Neurological Complications and Syndromes
Koriyama Institute of Health Sciences
2023-2025
Shizuoka Red Cross Hospital
2023-2025
Kanagawa Prefectural Institute of Public Health
2004-2024
Suzuki (Japan)
2011-2019
National Cerebral and Cardiovascular Center
2008-2019
Zenyaku Kogyo (Japan)
2019
Fukushima Medical University
2017-2018
Ochanomizu University
2009-2018
Kyorin University
2018
National Kyushu Medical Center
2017
MicroRNAs (miRNAs) belong to a class of the endogenously expressed non-coding small RNAs which primarily function as gene regulators. Growing evidence suggests that miRNAs have significant role in tumor development and may constitute robust biomarkers for cancer diagnosis prognosis. The miR-17-92 cluster especially is markedly overexpressed several cancers, associated with progression. In this study, we demonstrated miR-92a highly hepatocellular carcinoma (HCC). addition, proliferation...
The interannual Indian Ocean subtropical dipole (IOSD) event in the southern is discussed using a coupled general circulation model to derive scenario describing its complete life cycle for first time. positive (negative) IOSD characterized by an anomalous warm (cool) sea surface temperature (SST) southwestern region of and cool (warm) SST southeastern region. brings about enhanced precipitation Africa during peak phase. Composite pictures negative clarify that latent heat flux dominant...
New copper(II) intercalation compounds, {[Cu(CA)(H(2)O)(2)](G)}(n)() (H(2)CA = chloranilic acid; G 2,5-dimethylpyrazine (dmpyz) (1a and 1b) phenazine (phz) (2)) have been synthesized characterized. 1acrystallizes in the triclinic space group P&onemacr;, with a 8.028(2) Å, b 10.269(1) c 4.780(2) alpha 93.85(3) degrees, beta 101.01(2) gamma 90.04(3) Z 1. 1b crystallizes 8.010(1) 10.117(1) 5.162(1) 94.40(1) 97.49(1) 112.64(1) 2crystallizes 8.071(1) 11.266(1) 4.991(1) 97.80(1) 99.58(1) 83.02(1)...
Obesity and metabolic syndrome are important public concerns, there is increasing demand for effective therapeutic strategies. Flavonoids expected to improve the risk factors associated with syndrome. Anthocyanidins a kind of flavonoids; well known their anti-oxidative, anti-inflammatory anti-tumor properties. However, effects on adipocytes molecular systems not defined. In this study, we examined anthocyanidins-enriched bilberry extracts adipocyte differentiation.Utilizing 3T3-L1 cell line,...
The purpose of this study was to elucidate the factors that correlate with unfavorable outcomes and develop a simple validated model for assessing risk in patients minor ischemic stroke.The derivation cohort included 1,313 hospitalized within 72 hours after onset an initial NIH Stroke Scale score 0 3 enrolled prospective, multicenter, observational study. Unfavorable outcome defined as dependency (modified Rankin 3-5) or death at 90 days. predictive values related were evaluated. External...
ABSTRACT In Japan, more than 10% of streptococcal toxic shock-like syndrome (TSLS) cases have been caused by Streptococcus pyogenes M3/T3 isolates since the first reported TSLS case in 1992. Most from or severe invasive infection during 1992 to 2001 and those noninvasive this period are indistinguishable pulsed-field gel electropherograms. The longest fragments these recent were 300 kb size, whereas recovered before 1973 260 size. These 260- 300-kb hybridized each other, suggesting...
From November 2000 to July 2002, 112 fecal samples from pet reptiles, including 18 turtles, 71 lizards and 23 snakes, sold at a shop were examined for the prevalence of Salmonella spp. in Japan. isolated 83 (74.1%) samples, total isolates identified as subspecies I IV. The majority (62.5%) belonged 54 could be any 28 serovars. predominant serovars found S. Bardo, Newport Panama, which cause human salmonellosis. These results indicate that reptiles may potential infectious source salmonellosis
This study used ambulatory blood pressure (BP) monitoring to generate BP and heart rate (HR) profiles soon after stroke onset evaluated the association between determined values 3-month outcomes.We analyzed 24-hour records from 104 patients with acute ischemic stroke. Ambulatory was attached at second eighth hospitalization days (Days 1 7). Both HR were characterized using baseline, mean, maximum, minimum coefficient of variation during recording periods. Outcomes 3 months assessed as...
Sapovirus (SaV) infections are a public health problem because they cause acute gastroenteritis in humans of all ages both as outbreaks and sporadic cases. However, publicly-available SaV sequence information, especially whole genome sequences for the genotypes, is still limited. Therefore, this study, we determined full/near-full-length genomic 138 SaVs from 2001-2015 seasons 13 prefectures across Japan. The GI genogroup was predominant (67%, n = 92), followed by GII (18%, 25), GIV (9%,...
Abstract To evaluate DNA fingerprinting as an epidemiologic tool, pulsed‐field gel electrophoresis (PFGE) was performed on isolates of Salmonella , including S. typhimurium, thompson and enteritidis . Chromosomal digested with the restriction endonucleases Bln I Xba I. The patterns typhimurium from various sources were different one another. There no correlation between phage type digestion pattern isolates. Some strains belonging to distinguished by their PFGE in this study. These results...
Real-world data on the long-term adherence to- and efficacy of fremanezumab 675 mg quarterly dosing remain scarce. Our study evaluated of- patient to for episodic migraine (EM) chronic (CM) over 2 years analyzed reasons discontinuation. Among patients attending our headache outpatient clinic, those aged ≥ 15 who commenced dose schedule from November 2021 June 2022 were enrolled in this single-center observational study. The frequency severity headaches recorded using a diary. observation...
Treatment interruption and resumption are common among people with type 2 diabetes mellitus (T2D), but the triggers of resumption, according to reasons for interruption, remain underexplored. This study examined patterns treatment resumption. Narratives from 13 T2D patients a history were analysed through semi-structured interviews. Four identified: 1) "Economic rationality", where financial barriers caused interruptions, was facilitated by low-cost check-ups updated patient mindsets manage...
A facile method for the synthesis of 1- and 2-pyridylazulenes, 1,3-dipyridylazulenes, is described. Color spectral changes these pyridylazulenes upon addition either acid or metal ions were investigated in detail. The color changed from blue to red trifluoroacetic soft ions, depending on substitution patterns pyridyl group azulene skeleton. structures protonated coordinated products examined basis data. It was found that protonation coordination occurred nitrogen atom pyridine ring, but not...
Abstract A detailed investigation of the helical part resin‐supported peptide catalyst possessing a turn motif and unit was conducted to clarify structure‐activity relationship. The with an α‐ or 3 10 ‐helical tether effective for enantioselective Friedel–Crafts‐type alkylation in water. From spectral analysis optimum sequence, it demonstrated that moiety played role stabilizing terminal structure.
Porous carbons with high surface area were successfully prepared from thermoplastic precursors, such as poly (vinyl alcohol) (PVA), hydroxyl propyl cellulose (HPC) and (ethylene terephthalate) (PET), mixing MgO by the carbonization at 900°C in inert atmosphere. products was dissolved out using a diluted sulfuric or acetic acid. The pore structure of obtained characterized different analysis methods adsorption/desorption isotherms nitrogen 77K.The PVA had relatively micropore volume large...
There may be ethnic differences in carotid atherosclerosis and its contributing factors between Asian other populations. The purpose of this study was to examine intima-media complex thickness (IMT) the artery associated clinical Japanese stroke patients with hyperlipidemia from a cohort Japan Statin Treatment Against Recurrent Stroke Echo Study.Patients hyperlipidemia, not on statins, who developed noncardioembolic ischemic were included study. Mean IMT maximum distal wall common centrally...
The gene responsible for multiple endocrine neoplasia type 1 (MEN1) has recently been identified. Wide expression of the MEN1 in and non-endocrine organs examined by northern blotting reported, but detailed cellular distribution transcript each tissue not yet any species. In this report, adult human tissues was studied situ hybridization. widely observed all examined, an enhanced relation to cell proliferation seen some organs. Cell cycle arrest at G1-S border reduced mRNA level less than...
We assessed antimicrobial susceptibility against 211 Streptococcus pyogenes strains isolated from patients with severe invasive group A streptococcal infections. Overall, 3.8, 1.4, and 0.5% of the isolates were resistant to erythromycin, clindamycin, telithromycin, ciprofloxacin, respectively, 10.4% had intermediate resistance ciprofloxacin. All susceptible ampicillin cefotaxime.
Porous carbons with high surface area were successfully prepared from thermoplastic precursors, such as poly (vinyl alcohol) (PVA), by the carbonization of mixtures MgO precursor at 900°C in inert atmosphere. products was dissolved out using a diluted acid, either sulfuric or acetic acid. The carbon precursors (reagent grade magnesium acetate and citrate) mixed powder (powder mixing) aqueous solution (solution mixing). Pore structure resultant depended strongly on mixing method. BET obtained...
Abstract We studied the molecular evolution of capsid gene in all genotypes (genotypes 1–9) human norovirus (NoV) genogroup I. The evolutionary time scale and rate were estimated by Bayesian Markov chain Monte Carlo (MCMC) method. also performed selective pressure analysis B-cell linear epitope prediction deduced NoV GI protein. Furthermore, we analysed effective population size virus using skyline plot (BSP) analysis. A phylogenetic tree MCMC showed that diverged from common ancestor GII,...
Four isolates tentatively identified as Pseudaegerita matsushimae on the basis of morphology bulbil-like propagules were collected from substrates submerged in water Thailand and Japan. In culture studies two Thai found to produce phialoconidia conidiogenous cells phialoconidiophores whose was similar that Trichoderma. Phylogenetic analysis based D1/D2 regions LSU rDNA sequences showed four nested Hypocrea/Trichoderma (Hypocreales) while P. corticalis, type species Pseudaegerita, belongs...
Abstract A resin‐supported peptide with an N‐terminal primary amino group was developed as a aminocatalyst and used in the asymmetric Michael addition of nitromethane to α,β‐unsaturated ketones. These peptides helical motifs, that is, polyleucine repeated Leu‐Leu‐Aib (Aib=2‐aminoisobutyric acid) sequence, efficiently catalyzed reaction. The introduction two tryptophan residues at N‐terminus improved enantioselectivity reaction, using catalysts aqueous media enhanced reaction rate....