A5040692564- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Inflammatory mediators and NSAID effects
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Health and Disease Prevention
- Medical Imaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Clinical practice guidelines implementation
- Neurological and metabolic disorders
- Nausea and vomiting management
- Cardiac Health and Mental Health
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Estrogen and related hormone effects
- Neurological Complications and Syndromes
- Adipokines, Inflammation, and Metabolic Diseases
- Botulinum Toxin and Related Neurological Disorders
National Cerebral and Cardiovascular Center
2016-2025
Nagasaki Kawatana Medical Center
2023-2024
Nagasaki Medical Center
2015-2022
Kumamoto Medical Center
2020
Keio University
2014
Shiga University of Medical Science
2014
Dokkyo Medical University
2014
Kyushu University
2002
Mitsui Chemicals (Japan)
1995
Osaka City General Hospital
1995
<b>Objective: </b> The NIH Stroke Scale (NIHSS) may not appropriately assess the spectrum of posterior circulation (PC)–related neurologic deficits. We determined cutoff baseline NIHSS score that predicts independent daily life activity during chronic stage in anterior (AC) vs PC ischemic strokes. <b>Methods: A total 310 consecutive patients hospitalized within 3 days after onset an stroke were prospectively enrolled study. Patients on thrombolytic therapy excluded. In all patients, infarcts...
BackgroundAlthough statin therapy is beneficial for the prevention of initial stroke, benefit recurrent stroke and its subtypes remains to be determined in Asian, whom profiles are different from Caucasian. This study examined whether treatment with low-dose pravastatin prevents recurrence ischemic patients.MethodsThis a multicenter, randomized, open-label, blinded-endpoint, parallel-group patients who experienced non-cardioembolic stroke. All had total cholesterol level between 4.65 6.21...
Fluid shear stress induces cyclooxygenase (COX)-2 gene expression in vascular endothelial cells. We investigated the underlying mechanism of this induction.Exposure human umbilical vein cells to laminar physiological range (1 30 dyne/cm2) upregulated COX-2 but not COX-1, a constitutive isozyme COX. The mRNA began increase within 0.5 hour after loading and reached maximal level at 4 hours. Roles promoter region 3'-untranslated were evaluated by transient transfection luciferase reporter...
Background and Purpose —It remains unclear whether hemodynamic insufficiency plays a major role in ischemic events. We performed prospective follow-up study stroke patients with occlusive large-artery diseases to determine recurrence is related reduced vasodilatory capacity, judged single-photon emission CT acetazolamide (ACZ) challenge. Methods —During the period from 1987 1995, we examined cerebral capacity an ACZ challenge 105 consecutive severe stenosis (>75% diameter) or occlusion of...
Aim: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is known to be a key molecule in the pathogenesis of atherosclerosis. Although high levels serum soluble LOX-1 (sLOX-1) were demonstrated patients with acute coronary syndrome, there are no reports about stroke patients. The aim present study was evaluate sLOX-1 according different subtypes.
<i>Background and Purpose:</i> The influence of stroke subtype on recurrence, determinants recurrence-free survival after a first-ever are not fully understood. We aimed to clarify the long-term prognosis by subtypes identify for recurrence death stroke. <i>Methods:</i> enrolled 1,732 consecutive patients (men/women = 1,134/598, mean age 65 years) with acute who were admitted our Stroke Care Unit during period 20 years. classified as atherothrombotic brain infarction,...
This study used ambulatory blood pressure (BP) monitoring to generate BP and heart rate (HR) profiles soon after stroke onset evaluated the association between determined values 3-month outcomes.We analyzed 24-hour records from 104 patients with acute ischemic stroke. Ambulatory was attached at second eighth hospitalization days (Days 1 7). Both HR were characterized using baseline, mean, maximum, minimum coefficient of variation during recording periods. Outcomes 3 months assessed as...
Robot-assisted gait training following acute stroke could allow patients with severe disability to receive a high dosage and intensity of compared conventional physical therapy (CP). However, given the limited data on gauging efficacy Hybrid Assistive Limb (HAL) in stroke, we aimed evaluate several outcome measures HAL. Patients first-ever who required walking aid were able start within 1 week onset included current study. assigned either CP or HAL group. Outcome collected at baseline, 2nd...
血栓止血誌 21 (4) ：371～377, 2010 1. はじめに 本稿のテーマである「脳梗塞・TIA の抗凝固， 抗血小板療法」に関する， 「脳卒中治療ガイドラ イン 2009」 1) での主な改訂点は，1)超急性期血 栓溶解療法(アルテプラーゼ静注療法)の国内承 認，2)新たな章立てとして「TIA の急性期治療 と脳梗塞発症防止」の追記，3) 「脳梗塞慢性期： 再発予防のための抗血小板療法」にクロピドグレ ルのエビデンスの追記，4) 「脳梗塞慢性期：再発 予防のための抗凝固療法」にワルファリン休薬時 の対処法の追記である．本項では，こうした改訂 点を含め，脳梗塞・TIA の急性期および慢性期 における抗凝固， 抗血小板療法につき， 推奨グレー ド A, B の事項を中心に解説する．なお，準拠し たエビデンスレベルと勧告・推奨レベルの分類を 表 1, 2 に示す． 2. 脳梗塞急性期 (1)血栓溶解療法(静脈内投与) 推奨 rt-PA(アルテプラーゼ)の静脈内投与は発症 から 3 時間以内に治療可能な虚血性脳血管障害 で慎重に適応判断された患者に対して強く推奨さ...
Educating the youth about stroke is a promising approach for spreading knowledge. The aim of this study was to verify communication knowledge parents by educating junior high school students stroke.We enrolled 1127 (age, 13-15 years) and their in Tochigi prefecture, Japan. All received lesson, watched an animated cartoon, read related Manga comic as educational aids. took back home discussed what they learned with parents. Questionnaires on were given all at baseline immediately after...
<b><i>Introduction:</i></b> Cisplatin (CDDP)-induced nephrotoxicity is a concern in CDDP-based chemotherapy. The goal of this multicenter retrospective study was to identify potential risk factors for CDDP nephrotoxicity. <b><i>Methods:</i></b> Clinical data were reviewed 762 patients who underwent chemotherapy including ≥60 mg/m<sup>2</sup> per day from Spring 2014 September 2016. defined according the National Cancer Institute...
ObjectivesTo investigate whether early gait training using Hybrid Assistive Limb (HAL) is feasible and improves walking independency compared with conventional physical therapy (CPT) in patients severe disability after stroke.MethodsWe conducted a single-center, randomized controlled study. Patients first-ever stroke who had were included. All started within 10 days post-stroke onset. Twenty-four randomly assigned into HAL or CPT groups. Outcome measures collected at three time points,...
The authors recently developed a primate thromboembolic stroke model. To characterize the model, determined serial changes in cerebral blood flow (CBF) and relation between CBF metabolic rate of glucose (CMRglc) using high-resolution positron emission tomography. Thromboembolic was produced male cynomolgus monkeys (n = 4). Acute obstruction left middle artery achieved by injecting an autologous clot into internal carotid artery. Cerebral measured with [ 15 O]H2 O before 1, 2, 4, 6, 24 hours...