A5021591308- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Glycogen Storage Diseases and Myoclonus
- Neurological disorders and treatments
- Infectious Encephalopathies and Encephalitis
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Genetics and Neurodevelopmental Disorders
- Long-Term Effects of COVID-19
- Psychosomatic Disorders and Their Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Herpesvirus Infections and Treatments
- Cardiac Arrest and Resuscitation
- Viral Infections and Immunology Research
- Peripheral Artery Disease Management
Hiroshima University
2016-2025
Hiroshima University Hospital
2020-2025
Kyoto University
2016-2024
Fukushima Medical University
2019
Futaba (Japan)
2019
Fuji Heavy Industries Health Insurance Society Ota Memorial Hospital
2013-2017
Memorial Hospital of South Bend
2015
Journal Article Accepted manuscript Seizure clusters with typical "evolution" in EEG Get access Miharuka Yokosaki, MD, MD Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School Biomedical Health Sciences Search for other works by this author on: Oxford Academic PubMed Google Scholar Shuichiro Neshige, PhD, PhD SciencesEpilepsy center, Hospital Corresponding Author: 1-2-3 Minami-ku Kasumi, Hiroshima, 734-8551, Japan, TEL: (+81)-82-257-5201, email: [email...
Background: For effective epileptic seizure management, pharmacies need to provide physicians with information regarding drug-drug interactions, drugs that lower thresholds, and switching generic drugs. The aim of the study was clarify actual situation provision from investigate awareness epilepsy treatment in community pharmacies. Methods: A survey targeting all (1,512 pharmacies) belonging Hiroshima Prefectural Pharmacists Association conducted October 7, 2023, November 30, 2023....
Ventricular enlargement is commonly caused by brain atrophy or hydrocephalus; however, distinguishing between these conditions in elderly patients often challenging. This case report describes a patient whom secondary hydrocephalus was suspected based on characteristic findings of ventricular enlargement, leading to the final diagnosis. A 75-year-old man with nasal cavity malignant melanoma, treated nivolumab for six months, presented three weeks progressive lethargy and anorexia subsequent...
We herein report a 58-year-old female patient undergoing chimeric antigen receptor T-cell (CAR-T) therapy for refractory diffuse large B-cell lymphoma (DLBCL). Following the CAR-T infusion, experienced Cytokine Release Syndrome (CRS), which was subsequently remitted. However, aphasia observed five days post-infusion, and loss of consciousness occurred on sixth day. Brain MRI revealed possibly high signal intensity in mesial temporal region. The diagnosed with immune effector cell-associated...
Abstract Objective The impact of the coronavirus disease 2019 (COVID‐19) pandemic on epilepsy care across Japan was investigated by conducting a multicenter retrospective cohort study. Methods This study included monthly data frequency (1) visits outpatients with epilepsy, (2) outpatient electroencephalography (EEG) studies, (3) telemedicine for (4) admissions (5) EEG monitoring, and (6) surgery in centers clinics between January December 2020. We defined primary outcome as center‐specific...
Aim: Both the ankle brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are surrogates for atherosclerosis.In this study, we aimed to evaluate ability of ABI baPWV predict stroke outcome in patients with first-ever non-cardioembolic stroke.Methods: This study included consecutive admitted within 1 week after onset Ota Memorial Hospital between January 2011 December 2013.Baseline characteristics National Institutes Health scale scores at admission were noted.ABI evaluated 5...
To identify people with epilepsy (PWE) who required extensive care before the novel coronavirus disease 2019 (COVID-19) pandemic that had world-wide impacts on medical and socio-economic conditions.Consecutive PWE were treated at center of Hiroshima University Hospital, which was located in COVID-19 non-pandemic area, between March August 2020 enrolled. We evaluated clinical socioeconomic factors associated seizure exacerbation (an increase frequency) during first 6 months after started...
We report 10 cases with arterial ischemic stroke (AIS) nephrotic syndrome (NS), and clarified its incidence clinical characteristics. The patients having albumin less than 3.0 g/dl serum cholesterol greater 250 mg/dl at the same time were retrospectively screened from 11,161 of stroke. Furthermore, AIS showing heavy proteinuria selected. diagnosed as NS. Its was 0.09% all kinds 0.12% AIS. Their subtypes 6 large-artery atherosclerosis, 3 small-vessel occlusion, 1 cardioembolism. carried out a...
Abstract Objective Degree of indication for epilepsy surgery is determined by taking multiple factors into account. This study aimed to investigate the usefulness Specific Consistency Score (SCS), a proposed score focal rate resection. Methods retrospective cohort included patients considered resective in Kyoto University Hospital from 2011 2022. Plausible epileptic focus was tentatively defined. Cardinal findings were scored based on specificity and consistency with estimated laterality...
This retrospective review on patients with Parkinson's disease, focusing using mucuna beans (MB), its dosing, and administration methods. Two hundred taking 1–3 g of MP dissolved in hot water daily orally. Besides, MB via enema may be viable, especially when oral L-dopa efficacy is insufficient.
Giant somatosensory evoked potentials (SEPs) are observed in patients with cortical myoclonus. Short-latency components (SLC), regarded as epileptic activities or paroxysmal depolarization shifts (PDSs). This study aimed to reveal the electrophysiological significance of middle-latency component (MLC) P50 SEPs.
症例は66歳女性である.脳膿瘍で排膿術施行され,以後はメトロニダゾール2 g/日を投与された.30日目より嘔気出現し徐々に悪化,45日目に昏迷になった.意識変容,軽度の前庭障害と構音障害をみとめた.頭部MRIは脳梁膨大部,小脳歯状核,脳幹部下丘にDWIおよびFLAIRで高信号変化を両側対称性にみとめた.脳梁膨大部のapparent diffusion coefficient(ADC)は低下,MRSで乳酸のピーク上昇をみとめた.メトロニダゾール誘発性脳症と診断し,同薬剤を中止し,症状は改善し14日目に軽快退院した.小脳歯状核および脳幹病変は,血管障害性浮腫と思われ5~10日目には消失したが,脳梁膨大部病変は細胞毒性浮腫と思われ40日目まで残存した.
Abstract Background Benign adult familial myoclonus epilepsy (BAFME) is one of the diseases that cause cortical (CM) with giant somatosensory evoked potentials (SEPs). There are no useful diagnostic biomarkers differentiating BAFME from other CM diseases. Objective To establish reliable including high‐frequency oscillations (HFOs) SEPs for diagnosis BAFME. Methods This retrospective case study included 49 consecutive patients (16 and 33 patients) who exhibited P25 or N35 SEPs. were processed...
To explore the potential efficacy of early initiation intravenous cyclophosphamide (IVCPA), we reviewed consecutive four cases super-refractory cryptogenic-new onset refractory status epilepticus (C-NORSE) between 2015 and 2023. We compared functional outcomes at 3 months 1 year after patients who received IVCPA within 20 days (early-treated) those it later (late-treated). All (median age: 43 years) had a prodromal fever. Brain MRI revealed symmetrically increased FLAIR signals in medial...
硬膜下血腫患者連続1,009症例を対象とし,痙攣を併発した26例(2.6%)のうち血腫が痙攣を誘発した可能性のある20例をケース(痙攣群)として,性,年齢,手術の有無を1:2にマッチさせたコントロール群(非痙攣群)40例と比較した.痙攣群で認知症が多かったが,その他臨床項目で差異はみとめなかった.痙攣群で両側性血腫が多い傾向であり,MRIのFLAIR画像における脳溝の高信号(sulcal hyperintensity)を呈する症例が有意に多く,この所見を呈する症例はCT画像では混合性血腫内容を呈するものが多かった.血腫内容が脳実質へ浸潤して,刺激成分が痙攣を誘発する機序が推測された.