A5064334733- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Neuroendocrine Tumor Research Advances
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
- Renal cell carcinoma treatment
- Glycogen Storage Diseases and Myoclonus
- Soft tissue tumor case studies
- Neuroblastoma Research and Treatments
- IgG4-Related and Inflammatory Diseases
- Functional Brain Connectivity Studies
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Infectious Encephalopathies and Encephalitis
- Connective tissue disorders research
- Oral and Maxillofacial Pathology
- Neural dynamics and brain function
- Ear and Head Tumors
- COVID-19 and Mental Health
- Neurological and metabolic disorders
- Neurofibromatosis and Schwannoma Cases
- Neurological disorders and treatments
Tohoku University
2020-2025
Children's Hospital of Michigan
2020-2025
Wayne State University
2020-2025
Detroit Medical Center
2021-2025
International League Against Epilepsy
2025
Japanese Red Cross Kochi Hospital
2010-2024
Scientific Research WorkS Peer Support Group
2022-2024
Seirei Hamamatsu General Hospital
2017-2022
Michigan United
2022
National Hospital Organization Mito Medical Center
2021
Abstract Researchers have looked for rapidly- and objectively-measurable electrophysiology biomarkers that accurately localize the epileptogenic zone. Promising candidates include interictal high-frequency oscillation phase-amplitude coupling. Investigators independently created toolboxes compute rate severity of This study 135 patients determined what analytic approaches would optimally classify achieving post-operative seizure control. Four different detector computed at ≥80 Hz...
We investigated the developmental changes in high-frequency oscillation (HFO) and Modulation Index (MI) - coupling measure between HFO slow-wave phase. generated normative brain atlases, using subdural EEG signals from 8251 nonepileptic electrode sites 114 patients (ages 1.0-41.5 years) who achieved seizure control following resective epilepsy surgery. observed a higher MI occipital lobe across all ages, increased notably during early childhood. The cortical areas exhibiting co-growth were...
Progressively transformed germinal centers is a benign condition of unknown pathogenesis characterized by distinctive variant form reactive follicular hyperplasia in lymph nodes. We recently reported Ig G4-related disease progressively centers. However, no large case series has been and clinicopathologic findings remain unclear. Here, we report 40 Japanese patients (28 men, 12 women; median age, 56 years) with the nodes who fulfilled histological diagnostic criteria for IgG4-related (IgG4+...
The authors report a small case series of hybrid nerve sheath tumors occurring in the setting type 1 neurofibromatosis. Four lesions were benign and consisted plexiform neurofibromas with considerable areas perineuriomatous differentiation patients In these lesions, biphasic (Schwannian perineuriomatous) was apparent on immunohistochemistry, staining for epithelial membrane antigen, glut-1, claudin-1 being negative S-100 protein. Three members single family, history various malignant...
Objective: To investigate the clinical utility of deep convolutional neural network (DCNN) tract classification as a new imaging tool in preoperative evaluation children with focal epilepsy (FE). Methods: A DCNN deeply learned spatial trajectories DWI white matter pathways linking electrical stimulation mapping (ESM) findings from 89 FE, and then automatically identified associated eloquent functions (i.e., primary motor, language, vision). Clinical was examined by 1) measuring nearest...
OPINION article Front. Neurol., 26 June 2020Sec. Epilepsy Volume 11 - 2020 | https://doi.org/10.3389/fneur.2020.00722
ABSTRACT Epilepsy affects 1% of the population, with up to one-third patients being medication-resistant. Surgery is only curative treatment, yet over surgical fail achieve seizure freedom due lack a reliable epileptogenic zone (EZ) biomarker. We introduced and validated mini-seizures, frequent hypersynchronization events at EZ hubs that mirror network dynamics, as novel interictal EEG Using dynamical networks-based model, we analyzed short intracranial from 159 across two institutions. Our...
Objective: We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions. Methods: investigated 40 Japanese-speaking patients with focal epilepsy estimated measures using cortical high-gamma dynamics MRI tractography. Results: Hearing a wh-interrogative at question onset enhanced inter-hemispheric connectivity, left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by diminution...
Resective surgery for pediatric drug-resistant focal epilepsy often requires extraoperative intracranial electroencephalography recording to accurately localize the epileptogenic zone. This procedure entails multiple neurosurgeries, electrode implantation and explantation, days of invasive inpatient evaluation. There is a need methods reduce diagnostic burden introduce objective biomarkers. Our preliminary studies aimed address these issues by using sevoflurane anesthesia rapidly reversibly...
In the conventional neuropsychological model, nonverbal visuospatial processing is predominantly handled by right hemisphere, whereas verbal occurs in left, with right-hand responses governed left motor cortex. Using intracranial EEG and MRI tractography, we investigated timing white matter networks involved stimuli, forming response decisions, generating outputs. Within 200 ms of stimulus onset, observed widespread increases functional connectivity bidirectional neural flows from visual to...