A5010074263- Helicobacter pylori-related gastroenterology studies
- Carcinogens and Genotoxicity Assessment
- Magnetic Properties and Synthesis of Ferrites
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- Iron oxide chemistry and applications
- Bladder and Urothelial Cancer Treatments
- Drug-Induced Hepatotoxicity and Protection
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Glutathione Transferases and Polymorphisms
- Photovoltaic System Optimization Techniques
- Advanced Thermoelectric Materials and Devices
- Silicon and Solar Cell Technologies
- solar cell performance optimization
- X-ray Diffraction in Crystallography
- Eosinophilic Esophagitis
- X-ray Spectroscopy and Fluorescence Analysis
- Veterinary medicine and infectious diseases
- Multiferroics and related materials
- Phytochemistry and Bioactive Compounds
- Neuroscience and Neuropharmacology Research
- Galectins and Cancer Biology
- Japanese History and Culture
- Polyamine Metabolism and Applications
National Institute of Health Sciences
2016-2025
Nippon Steel (Japan)
2024
National Institute of Health Sciences
2011-2023
Centre International de Recherche sur le Cancer
2023
Industrial Research Institute of Ishikawa
2008-2020
Aichi Cancer Center
2007-2015
National Institute of Infectious Diseases
2015
Tokyo Institute of Technology
1997-2014
The University of Tokyo
2007-2014
Fujita Health University
2013
Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection gastric epithelial cells are thought to contribute cancer risk. However, it is unclear whether this increased risk reflects an infection-associated inflammatory response or the itself. In study, we sought clarify mechanisms in a gerbil model where showed that HP causally involved induction aberrant methylation. By genome-wide screening, CpG islands were aberrantly methylated cell lines isolated, and 10...
Malignant mesothelioma (MM) is an incurable malignancy that caused by exposure to asbestos and accompanied severe fibrosis. Because MM usually diagnosed at advanced stage clinical identification of early lesions difficult, its molecular pathogenesis has not been completely elucidated. Nearly 75% cases have inactivating mutations in the NF2 (neurofibromatosis type 2; Merlin) gene or downstream signaling molecules Hippo cascade, which negatively regulates transcription factor Yes-associated...
In this study, we aimed to evaluate changes in the acute toxicity of intraperitoneally administered silver nanoparticles (AgNPs) varying sizes BALB/c mice. Seven-week-old female mice were AgNPs measuring 10, 60, or 100 nm diameter (0.2 mg/mouse) and then sacrificed 1, 3, 6 h after treatment. 10 AgNPs, reduced activity piloerection observed at 5 post administration, lowered body temperature was with histopathological congestion, vacuolation, single cell necrosis, focal necrosis liver;...
Effect of rare-earth elements (Y and Dy) on the mechanical properties Mg solid solution single crystal is investigated. Comparing with effect other reported by previous studies, strengthening Y Dy are much higher than that additives such as Zn for basal slip operation, while isotropic strain atoms those Dy. Strain-rate changing tests were conducted a further understanding dislocation motion it revealed activation volumes estimated alloys smaller Zn-added alloy, enthalpy almost same. It was...
Synaptic plasticity is a cellular mechanism putatively underlying learning and memory. However, it unclear whether induces synaptic modification globally or only in subset of neurons associated brain regions. In this study, we genetically identified activated during contextual fear separately recorded efficacy from recruited nonrecruited the mouse basolateral amygdala (BLA). We found that presynaptic potentiation, which was reflected by an increase miniature EPSC frequency decrease...
Abstract Suppression of aberrant DNA methylation is a novel approach to cancer prevention, but, so far, the efficacy strategy has not been evaluated in cancers associated with chronic inflammation. Gastric induced by Helicobacter pylori infection are known involve and severe inflammation their early stages. Here, we aimed clarify whether suppression can prevent H. pylori–induced gastric using Mongolian gerbil model. Administration demethylating agent, 5-aza-2′-deoxycytidine (5-aza-dC),...
Chronic inflammation is deeply involved in induction of aberrant DNA methylation, but it unclear whether any type persistent can induce methylation and how cell proliferation involved. In this study, Mongolian gerbils were treated with five kinds inducers [ Helicobacter pylori cytotoxin-associated gene A (CagA), H.pylori without CagA, Helicobacterfelis , 50% ethanol (EtOH) saturated sodium chloride (NaCl) solution]. Two control groups a mutagenic carcinogen that induces little (20 p.p.m. N...
Nuclear factor-kappaB (NF-kappaB) plays a major role in host inflammatory responses and carcinogenesis as such is an important drug target for adjuvant therapy. In this study, we examined the effect of caffeic acid phenethyl ester (CAPE), NF-kappaB inhibitor, on Helicobacter pylori (H. pylori)-induced activation cell culture chronic gastritis Mongolian gerbils. AGS gastric cancer cells, CAPE significantly inhibited H. pylori-stimulated mRNA expression several factors dose-dependent manner,...
Abstract Background Spices have been used for thousands of years, and recent studies suggest that certain spices confer beneficial effects on gastric disorders. The purpose this study was to evaluate possible chemopreventive spice‐derived compounds H elicobacter pylori ( . )‐induced gastritis. Methods We examined the inhibitory curcumin, capsaicin, piperine in vitro by determining colony‐forming units real‐time RT ‐ PCR H. stimulated AGS cancer cells. For vivo analysis, 6‐week‐old SPF male M...
Abstract Oxidative stress is linked to gastric carcinogenesis because of its ability damage DNA. Here we examined antioxidative and anti‐inflammatory effects 4‐vinyl‐2,6‐dimethoxyphenol (canolol), a recently identified potent compound obtained from crude canola oil, on Helicobacter (H .) pylori ‐induced gastritis using Mongolian gerbil model. The animals were allocated H. ‐infection alone (12 weeks) or H.pylori + N ‐methyl‐ ‐nitrosourea (MNU) administration (52 weeks). After oral inoculation...
Malignant mesothelioma (MM) is a neoplasm that arises from serosal surfaces of the pleural, peritoneal and pericardial cavities with worldwide incidence, much which caused by asbestos exposure. Patients suffer pain dyspnea due to direct invasion chest wall, lungs vertebral or intercostal nerves masses thick fibrotic tumors. Although there has been recent progress in clinical treatment, current therapeutic approaches do not provide satisfactory results. Therefore, development molecularly...
Abstract Background Though titanium dioxide (TiO 2 ) is generally considered to have a low impact in the human body, safety of TiO containing nanosized particles (NPs) has attracted attention. We found that toxicity silver NPs markedly varied depending on their particle size, as with diameter 10 nm exhibited fatal female BALB/c mice, unlike those diameters 60 and 100 nm. Therefore, toxicological effects smallest available crystallite size 6 were examined male F344/DuCrlCrlj rats by repeated...
3-Monochloropropane-1,2-diol (3-MCPD) is regarded as a rat renal and testicular carcinogen has been classified possible human (group 2B) by International Agency for Research on Cancer. This potentially of great importance given that esters this compound have recently found to be generated in many foods food ingredients result processing. There few reports about their toxicity, although we the toxicity profile 3-MCPD was similar 13-week repeated dose study, except acute seen 3-MCPD-treated...
Abstract Background Helicobacter pylori ( H. ) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two with gene expression profiles during gastric carcinogenesis remain unclear. In the present study, we investigated global associated prognosis human using a mouse model. Methods To find candidate genes involved carcinogenesis, firstly constructed carcinogen-induced tumor model combined high-salt diet. C57BL/6J...
DNA double-strand breaks (DSBs) induced by exposure to genotoxic agents are known cause genome instability and cancer development. To evaluate the applicability of γ-H2AX, a sensitive marker DSBs, in early detection genotoxicity carcinogenicity chemicals using animal models, we examined γ-H2AX expression urinary bladders rats. Six-week-old male F344 rats were orally treated for 4 weeks with total 12 divided into categories based on bladder. Animals sacrificed at end administration or after 2...
Diffuse alveolar damage (DAD) is a pathological hallmark of severe interstitial lung diseases, such as acute respiratory distress syndrome (ARDS), and linked to poor prognosis. Previously, we identified 14–3–3σ/stratifin (SFN) serum biomarker candidate for diagnosing DAD. To clarify the time-dependent relationship between SFN expression DAD, here investigated molecular changes in serum, bronchoalveolar lavage fluid (BALF), tissue an oleic acid (OA)-induced ARDS rat model. Acute edema was...
Although blood triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels are useful for detecting antithyroid compounds in rodent toxicity studies, there challenges with high variability due to sampling conditions. Here, we compared histopathological immunohistochemical findings rats treated promoters of thyroid metabolism explore markers hypothyroidism. Six-week-old male female Sprague-Dawley (5/group) were administered phenobarbital sodium salt (NaPB) or...