A5087482372- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related Molecular Pathways
- Nuclear Receptors and Signaling
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Alcoholism and Thiamine Deficiency
- Intracerebral and Subarachnoid Hemorrhage Research
- Medicinal Plant Pharmacodynamics Research
- Evolutionary Algorithms and Applications
- Nerve injury and regeneration
- Cognitive Science and Mapping
- Lipid metabolism and disorders
- Zebrafish Biomedical Research Applications
Kumamoto University
2022-2025
Hokkaido University
2016-2024
Pharmac
2021-2023
Massachusetts Institute of Technology
2022
Hokkaido Pharmaceutical University
2021
The University of Tokyo
2010-2019
Fukuoka Dental College
2017
École Polytechnique Fédérale de Lausanne
2014-2016
Oncogenic mutant p53 is one of the targets for cancer therapy, and development anticancer drugs that reactivate a promising strategy. The extract fungus Pestalotiopsis sp. changed to wild-type-like in Saos-2 (p53R175H) cells, as shown by fluorescent immunostaining, bioassay-guided purification afforded new dimeric epoxyquinoids, pestones A B (1 2), known compound, rosnecatrone (3). relative absolute configurations 1 2 were determined based on spectroscopic data semisynthesis from 3....
Synaptic plasticity is a cellular mechanism putatively underlying learning and memory. However, it unclear whether induces synaptic modification globally or only in subset of neurons associated brain regions. In this study, we genetically identified activated during contextual fear separately recorded efficacy from recruited nonrecruited the mouse basolateral amygdala (BLA). We found that presynaptic potentiation, which was reflected by an increase miniature EPSC frequency decrease...
Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse spite successful fear reduction through extinction-based exposure therapy. By utilising contextual fear-conditioning task mice, we found that was accompanied by decreased c-Fos expression the infralimbic cortex (IL) with synaptic input and enhanced medial subdivision central nucleus amygdala (CeM). Moreover, IL dopamine plays key role reinstatement. A reinstatement-inducing...
Abstract Background Selecting an appropriate behavior is critical for survival in conflict situations during which animals face both appetitive and aversive stimuli. Animals exhibit several processes. First, they stay still a safe place (suspension); once decide to take action, assess risks at where danger may occur (risk assessment) finally reach the reward. However, most studies have not addressed these Aims & Objectives We developed new experimental paradigm– three-compartment task–...
The antidepressant effect of eicosapentaenoic acid-derived bioactive lipid, resolvin E1 (RvE1), was examined in a murine model chronic pain-induced depression using tail suspension test. Because RvE1 reportedly possesses agonistic activity on chemerin receptor ChemR23, we also the chemerin. Two weeks after surgery for unilateral spared nerve injury to prepare neuropathic pain mice, immobility time measured Chronic significantly increased time, and this depression-like behavior attenuated by...
Significance Cortical neurons exhibit spontaneous activity without explicit external stimuli. Sensory stimuli not only activate specific populations of those but can also silence other populations. However, it remains unclear whether neuronal silencing per se leads to memory formation and behavioral expression. Here, we used optogenetic a ensemble in the auditory cortex found that mice exhibited fear response had been previously paired with footshock, could find reward based on presence or...
Homer1a, an activity-dependent induced member of the scaffold protein family Homer, plays essential role in synaptic reorganization and is widely used as a neuronal activity marker. However, cell type transcribing Homer1a remains unidentified. Here, we investigated main types amygdala, hippocampus, primary somatosensory cortex, dorsal striatum that express Homer1a. expression relevant to baseline neural well exposure unfamiliar conditioned contexts was preferentially detected excitatory...
Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant has attracted attention for cancer therapy. We isolated colletofragarone A2 (CF) from fungus Colletotrichum sp. (13S020), which decreases levels in cells, and herein examine effect on p53. CF showed more potent cytotoxic activities cells with p53R175H structural mutants than those different statuses such as a DNA-contact...
The aim of this study was to investigate the effect three metal priming agents on bond strength adhesive resin cement Silver-Zinc-Tin-Indium (Ag-Zn-Sn-In) alloy and pure Ag, Zn, Sn, In. specimens were air-abraded with alumina then primed one agents: V-Primer, Estenia Opaque Primer, or Alloy Primer. disks bonded (Super-Bond Bulk-mix technique). Shear strengths (n=10/group) determined before after 50,000 thermocycles for Ag-Zn-Sn-In as well 5,000 Sn For alloy, post-thermocycling Primer group...
Conditioned fear is extinguished if a conditioned animal receives the stimulus without an unconditioned stimulus. The response can be reinstated after experiences mild Although extensive studies on neuronal circuitry and neurochemical mechanisms leading to acquisition extinction have been carried out, few focused reinstatement. In this study, we investigated effects of N-methyl-D-aspartic acid receptor (NMDAR) antagonists, protein synthesis inhibitors, cannabinoid type 1 (CB1R)...
There is a great deal of individual variability in the emotional outcomes potentially traumatic events, and underlying mechanisms are only beginning to be understood. In order further our understanding trajectories trauma, its vulnerability resilience, we adapted model fear expression ambiguous vs perfect cues adult male rats, examined long-term extinction, 2, 3, 50 days from acquisition. After final conditioned test, mitochondrial enzyme monoamine oxidase A (MAOA) function was examined....
Abstract Aim We previously demonstrated that intracerebroventricular injection of resolvin D2 (RvD2), a bioactive lipid mediator derived from docosahexaenoic acid, ameliorated depression‐like behavior in lipopolysaccharide‐induced and chronic mild stress–induced mouse models depression. In the present study, we examined antidepressant effect RvD2 on pain–induced behavior. Methods To prepare neuropathic pain model, mice were subjected to surgery for unilateral spared nerve injury. Two weeks...
Introduction: Aromatic (Ar)-turmerone is a bioactive component of turmeric oil obtained from Curcuma longa . We recently identified novel analog (A2) ar-turmerone that protects dopaminergic neurons toxic stimuli by activating nuclear factor erythroid 2-related 2 (Nrf2). D-cysteine increases Nrf2, leading to the activation chaperone-mediated autophagy (CMA), pathway in autophagy-lysosome protein degradation system, primary cultured cerebellar Purkinje cells. In this study, we attempted...