A5065059203- Temporomandibular Joint Disorders
- Laser Applications in Dentistry and Medicine
- Chemical Reaction Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Salivary Gland Disorders and Functions
- Craniofacial Disorders and Treatments
- Chemical Reactions and Isotopes
- Pain Mechanisms and Treatments
- Inorganic and Organometallic Chemistry
- Dental Erosion and Treatment
- Synthesis and Reactions of Organic Compounds
- Trigeminal Neuralgia and Treatments
- Myofascial pain diagnosis and treatment
- Chemical Synthesis and Reactions
- Adipokines, Inflammation, and Metabolic Diseases
- Coordination Chemistry and Organometallics
- Petroleum Processing and Analysis
- Fluorine in Organic Chemistry
- Orthodontics and Dentofacial Orthopedics
- Analytical Chemistry and Chromatography
- Oropharyngeal Anatomy and Pathologies
- Catalysis and Oxidation Reactions
- Advanced Chemical Sensor Technologies
Nihon University
2014-2025
Kumamoto University
2025
Matsudo City Hospital
2020-2025
Osaka University Hospital
2014
Nagashima Hospital
2009
Kishiwada Tokushukai Hospital
2007-2009
University of California, Los Angeles
2005
Mahidol University
2005
Saga University
1989-1994
Universidade Estadual de Campinas (UNICAMP)
1993
Oncogenic mutant p53 is one of the targets for cancer therapy, and development anticancer drugs that reactivate a promising strategy. The extract fungus Pestalotiopsis sp. changed to wild-type-like in Saos-2 (p53R175H) cells, as shown by fluorescent immunostaining, bioassay-guided purification afforded new dimeric epoxyquinoids, pestones A B (1 2), known compound, rosnecatrone (3). relative absolute configurations 1 2 were determined based on spectroscopic data semisynthesis from 3....
This study compared pain intensity and psychosocial characteristics between patients with burning mouth syndrome (BMS) those trigeminal neuralgia (TN). Data from 282 BMS 83 TN were analyzed. Patients reported duration of illness: ≤ 6 months was defined as acute illness > chronic illness. Present worst during the past using a 0-10 numeric rating scale (NRS). In addition, depression somatization scores evaluated on questionnaires. significantly higher had worse than did BMS. Pain in patients,...
We investigated the relationship between pain intensity and psychosocial characteristics in patients with temporomandibular disorder (TMD). Participants painful TMD, according to Research Diagnostic Criteria for TMD (RDC/TMD), were recruited from our clinic classified into six age groups: 15 24, 25 34, 35 44, 45 54, 55 64, 65 85 years (Groups A through F, respectively). Self-reported present worst during past 6 months ascertained using a numeric rating scale (0 10). Depression somatization...
We evaluated the mechanisms underlying oxytocin (OXT)-induced analgesic effect on orofacial neuropathic pain following infraorbital nerve injury (IONI). IONI was established through tight ligation of one-third thickness. Subsequently, head withdrawal threshold for mechanical stimulation (MHWT) whisker pad skin measured using a von Frey filament. Trigeminal ganglion (TG) neurons innervating were identified retrograde labeling technique. OXT receptor-immunoreactive (IR), transient receptor...
The aim of this study was to evaluate the relationship between pain intensities and psychosocial characteristics in middle-aged older patients with temporomandibular disorders (TMDs) burning mouth syndrome (BMS). Subjects were selected according Research Diagnostic Criteria for TMD (n = 705) International Association Study Pain criteria BMS 175). Patients then divided into two age groups: 45-64 years (middle-aged, Group A) 65-84 (older, B). intensity depression somatization scores evaluated...
Headaches are a common complaint in temporomandibular disorder (TMD) patients. However, few studies have compared the symptom characteristics between TMD patients with and without of headache. The aim this study was to compare subjective symptoms treatment outcomes myofascial who had chief headache those did not.
The purpose of this study was to compare learning need reports generated by students during their investigation a problem-based (PBL) case with the faculty-identified objectives established for it. Four PBL cases facilitated four group tutors were selected comparison. student-generated needs collected each and compared faculty-specified outcomes. results analyzed individual among student groups. Over 96 percent across all groups covered reports. Only one demonstrated statistically...
There is little evidence regarding the reliability of CPT and PT measurements to gauge mandibular perception. Thus, this study aimed evaluate test-retest values obtained from oral mucosa test bilateral differences in mental foramen region buccal shelf by a single operator.CPT were regions 20 volunteers (10 males 10 females; average age: 26.4 ± 2.6 years) using Neurometer CPT/C® device deliver electrical stimulation.Relative absolute reliabilities confirmed over two 7- 10-day measurement...
The irritation and pain associated with oral blood sampling necessary to monitor glycemic control can alter sensation, but no studies have measured the reliability of sensation testing when performed concurrently sampling. primary secondary aims this study were verify measurement current perception threshold (CPT) (PT) tests before after investigate differences in CPTs/PTs obtained from cavity, hand, foot, respectively. CPT/PT measurements mucosa tips fingers toes 18 volunteers (10 males 8...
Background: The cognitive effects of wearing a denture are not well understood. This study was conducted to clarify the use on prefrontal and chewing muscle activities, occlusal state, subjective ability in partially edentulous elderly individuals. Methods: Sixteen patients were enrolled. Chewing-related cortex jaw activities simultaneously examined using an fNIRS device electromyography, under conditions unwearing denture. Occlusal state masticatory score also determined both conditions....
There is little evidence of sensation in individuals with diabetes mellitus (DM) the dental research field. We investigated whether pain thresholds (PTs) differ between and without DM (non-DM; NDM). To this end, we assessed PTs obtained from oral cavity, hands, feet differed each other across groups, for three current frequencies used testing (2000 Hz, 250 5 Hz). Pain threshold measurements were mucosa tips fingers toes 56 volunteers, including 21 (12 men 9 women, average age: 72.1 ± 4.7...
Jaw and neck muscles may be activated by chewing load using a hard food. However, it remains unclear how effects the gum hardness to coordinated features in jaw muscle activities during performance.This study was conducted quantitatively elucidate of on intermuscular EMG-EMG transfer function coherence analyses 18 healthy subjects.Jaw were aggregated into first peak frequency power spectrum, power, gain, phase, parameters between examined frequencies soft chewing.The not significantly...
カルボン酸トリウム塩(R(COO)4Th)の脱炭酸のおこり易さを14C-標識法と分解温度を測定する方法とで比較してみたが,二つの方法で得られた結果はギ酸塩を除けば一致した。脱炭酸のおこり易さの順序は,R-:C6H5CH2->CH3->CH3CH2CH2->C6H5->(CH3)3C-となり,これは同じカルボン酸のエチルエステルのアルカリ性加水分解速度の順序と並行することがわかった。
1虐パラ置換フェニル酢酸トリウム塩の脱炭酸反応における置換基効果を,分解温度を測定することによってしらべた。フェニル酢酸トリウムの分解澱をTH,置換体の場合のそれをTsとするとHammettのパラ置換基定数σpとの間に,TH/Ts=pTσ0の関係が成立することが見いだされた。反応定数mは+0.071であって,この反応が求核反応の性質をもつことを示唆している。
This study was performed to evaluate the association of jaw and neck muscle coordination with movement activity in order clarify relationships electromyogram（EMG）-EMG findings showing coherence between activities while chewing healthy individuals. Sixteen subjects gum chewing, EMG signals muscles movements were simultaneously recorded. Coherence as well first peak frequency power spectrum, analyzed left right side using EMG-EMG function analysis. Those results used relationship rhythmical...
This study investigated changes in chewing satisfaction from old to new dentures, exploring how perceived masticatory difficulty with the denture influenced food intake dentures. Additionally, factors influencing overall dentures were examined. Consecutive sampling involved edentulous individuals seeking replacements for both maxillary and mandibular complete A total of 103 individuals(49 males, 54 females; age range: 39-87 years; mean age: 71.6±8.6 years)participated. At baseline visit,...
This study explored the relationship between central sensitization symptoms, assessed using Central Sensitization Inventory (CSI), and psychophysical factors in patients with chronic masticatory myofascial pain (MMP) transitioning from acute to stages.
We describe a case of trigeminal neuralgia caused by compensatory enlargement the basilar artery in patient with bilateral agenesis internal carotid arteries. A 46-year-old man experienced sharp, stabbing pain left face when washing his face. In imaging examinations, magnetic resonance imaging(MRI)revealed displacement nerve due to and leftward deviation, but no brain tumors or other abnormalities. The was not visible on angiography(MRA), marked vertebral arteries seen, along considerable...
We elucidated the effects of orexin-A in dorsal root ganglion (DRG) neurons. Immunohistochemical staining was performed to compare changes N-methyl-daspartate receptors (NMDARs) and DRG between carrageenaninduced neuropathic pain rat model (CA) non-algetic rats (Control). also evaluated inhibitory by measuring [Ca2+] i. Using immunohistochemistry, expression observed both posterior anterior horns spinal cord. No major difference groups. neurons DRG, no NMDAR levels horn cord were not...
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