A5100775324- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Physiological and biochemical adaptations
- Sports injuries and prevention
- Aquaculture Nutrition and Growth
- Silk-based biomaterials and applications
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Lower Extremity Biomechanics and Pathologies
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Aquaculture disease management and microbiota
- Orthopedic Surgery and Rehabilitation
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Adhesion, Friction, and Surface Interactions
- Molecular Sensors and Ion Detection
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Planarian Biology and Electrostimulation
Second Affiliated Hospital of Zhejiang University
2016-2025
Zhejiang University
2016-2025
China Medical University
2025
Zhejiang Lab
2022-2025
Blood Center of Zhejiang Province
2025
Chongqing Normal University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2017-2024
Ningbo Academy of Agricultural Sciences
2016-2024
Tropical Crops Genetic Resources Institute
2024
BackgroundOral antiviral drugs with improved potency and safety are needed to address current challenges in clinical practice for treatment of COVID-19, including the risks rebound, drug-drug interactions, emerging resistance.MethodsOlgotrelvir (STI-1558) is designed as a next-generation targeting SARS-CoV-2 main protease (Mpro), an essential enzyme replication, human cathepsin L (CTSL), key entry into host cells.FindingsOlgotrelvir highly bioavailable oral prodrug that converted plasma its...
The anterior cruciate ligament consists of 2 functional bundles, the anteromedial bundle and posterolateral bundle. Single-bundle reconstruction is current standard for treatment deficiency. However, a significant subset patients continues to report residual symptoms instability after such reconstruction.Anatomic double-bundle may more closely restore normal kinematics knee by reproducing native anatomy.Case series; Level evidence, 4.We clinical outcomes initial 100 consecutive who underwent...
Tendon stem/progenitor cells (TSPCs) were recently identified within tendon tissues. The aim of this study was to investigate TSPC-seeded knitted silk—collagen sponge scaffold for functional shoulder repair. multidifferentiation potential, proliferation, and immune properties TSPCs investigated in vitro, while the efficacy scaffolds promoting rotator cuff regeneration evaluated vivo a rabbit model. TSPCs, which exhibited universal stem cell characteristics (i.e., clonogenicity, high...
Nestin defines a novel tendon stem/progenitor cell subpopulation with high tenogenesis potential.
As tendon stem/progenitor cells were reported to be rare in tissues, tendons as vulnerable targets of sports injury possess poor self-repair capability. Human ESCs (hESCs) represent a promising approach regeneration. But their teno-lineage differentiation strategy has yet defined. Here, we report that force combined with the tendon-specific transcription factor scleraxis synergistically promoted commitment hESCs tenocyte for functional tissue Force and can independently induce...
Background: Chronic tendinopathy is a commonly occurring clinical problem that affects both athletes and inactive middle-aged patients. Although some studies have shown different platelet-rich plasma (PRP) preparations could exert various therapeutic effects in vitro, the role of leukocytes PRP has not yet been defined under conditions vivo. Purpose: This study compared intratendon delivery leukocyte-poor (Lp-PRP) versus leukocyte-rich (Lr-PRP) rabbit chronic model Study Design: Controlled...
Abstract Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain the short-term but often leads to osteoarthritis (OA) long-term. In this study, we report a new strategy of articular cartilage protection by intra-articular injection novel human meniscus stem/progenitor cells (hMeSPCs). We found that hMeSPCs displayed both mesenchymal stem cell characteristics and high expression levels collagen II. rat...
Heterotopic ossification (HO) in connective tissues like tendons and ligaments severely damages tissue structure. The pathogenesis of HO remains unclear but may involve mTOR. results presented here indicate that tendon stem/progenitor cells do not undergo osteochondrogenic differentiation when mTOR signaling is inactivated by gene knockout or rapamycin (RAPA) treatment. Meanwhile, it necessary to deliver RAPA the injured sites avoid disturbing normal tendon. A delivery system, developed...