A5100561949- Spondyloarthritis Studies and Treatments
- Electrochemical sensors and biosensors
- Bone and Joint Diseases
- Dye analysis and toxicity
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Advanced biosensing and bioanalysis techniques
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- Biochemical Analysis and Sensing Techniques
- Autophagy in Disease and Therapy
- Electrochemical Analysis and Applications
- Aquaculture disease management and microbiota
- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- Industrial Vision Systems and Defect Detection
- Pharmacological Effects and Assays
- Psoriasis: Treatment and Pathogenesis
- Neonatal and Maternal Infections
- Toxin Mechanisms and Immunotoxins
- Stoma care and complications
- Galectins and Cancer Biology
- Growth Hormone and Insulin-like Growth Factors
- Effects and risks of endocrine disrupting chemicals
- Hip disorders and treatments
Southeast University
2018-2025
Sun Yat-sen University
2024-2025
Jiangsu Food and Pharmaceutical Science College
2015-2025
Oxford Policy Management
2025
University of Oxford
2025
Nantong University
2024
Shanghai University
2023-2024
Structure Based Design (United States)
2024
Nantong Maternity and Child Health Hospital
2024
Air Force Medical University
2012-2023
BackgroundOral antiviral drugs with improved potency and safety are needed to address current challenges in clinical practice for treatment of COVID-19, including the risks rebound, drug-drug interactions, emerging resistance.MethodsOlgotrelvir (STI-1558) is designed as a next-generation targeting SARS-CoV-2 main protease (Mpro), an essential enzyme replication, human cathepsin L (CTSL), key entry into host cells.FindingsOlgotrelvir highly bioavailable oral prodrug that converted plasma its...
ABSTRACT Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease with severe symptoms in the axial skeleton. The cause of ankylosing unknown. TNFAIP3, also named A20, uses ubiquitin-related functions to regulate immune activation, deficiency which highly related disease. However, role TNFAIP3 human AS has not been reported. Our objective was study and mechanism spondylitis. expression on different types immunocytes from peripheral blood measured by flow cytometry. In vitro,...
Forkhead box P3 (FoxP3)-positive regulatory T cells (Tregs) play a pivotal role in the preservation of self-tolerance, and Treg dysfunction has been implicated many autoimmune diseases. Whether how Tregs participate pathogenesis ankylosing spondylitis (AS) not fully elucidated. Here, we investigated function found that peripheral blood (PB) from patients with active AS had lower FoxP3 mean fluorescence intensity (MFI) than those healthy controls could suppress naïve cell (Tn) proliferation....
BackgroundAnkylosing spondylitis (AS) is a chronic inflammatory disease with worldwide high prevalence. Although AS strongly associated HLA-B27 MHC-I antigen presentation, the role played by αβ T cells in remains elusive.MethodsUtilizing TCRβ repertoire sequencing and bioinformatics tools developed house, we analyzed overall TCR structures antigen-recognizing CDR3 motifs patients different activities.FindingsWe found that progression both CD4+ CD8+ cell oligo-clonal expansion, which suggests...
Background: This study aimed to investigate the effects of electroacupuncture (EA) on cognitive recovery and synaptic remodeling in a rat model middle cerebral artery occlusion (MCAO) followed by reperfusion explore possible mechanism. Method: Focal ischemia was modeled healthy adult Sprague-Dawley rats MCAO. The MCAO were classified into four groups: sham, MCAO, + GB20 (receiving EA at GB20) NA “non-acupoint” location not corresponding any traditional acupuncture point about 10 mm above...
Activated platelets exert a proinflammatory action that can be largely ascribed to their ability interact with monocytes. However, the mechanisms promote dynamic changes in monocyte subsets rheumatoid arthritis (RA) have not been clearly identified. The aim of this study was determine whether platelet activation and consequent formation monocyte-platelet aggregates (MPA) might induce phenotype circulating monocytes RA.The surface frequencies subpopulations peripheral blood RA patients were...
Abstract Mesenchymal stem cells (MSCs) are multi-potent that self-renewable and possess the potential to differentiate into multiple lineages. Several studies demonstrated MSCs could regulate a Th17/Treg balance be therapeutic target for Rheumatoid Arthritis (RA). A20 is highly expressed in many cell types after stimulation of TNF-α, where it may inhibit pro-inflammatory cytokine secretion. However, expression BM-MSCs RA not fully understood. In our study, we found was decreased patients’...
Abstract Background China has experienced a continuous decline in fertility rates, despite the end of one-child policy, further intensifying population ageing. Timely evidence on factors associated with childlessness among Chinese women is needed, alongside examining reproductive anxiety childless age. Methods This nationwide, cross-sectional study was based 2023 Psychology and Behavior Investigation Residents Survey. A total 10,802 across mainland who were (or had been) married included,...
Vitamin D plays a crucial role in skeletal metabolism and is implicated various diseases. Several studies have indicated that human vitamin status can be evaluated through urine hydroxyvitamin levels, addition to plasma concentrations. In this study, we developed novel method for the detection of trace amounts 25-hydroxyvitamin D3 [25(OH)D3] 24,25-dihydroxyvitamin [24,25(OH)2D3] urine. This based on high-performance liquid chromatography coupled with atmospheric pressure chemical ion...
Objectives: Hip inflammation is one of the most common complications in patients with spondyloarthritis (SpA). Herein, we employed use a deep learning-based magnetic resonance imaging (MRI) evaluation model to identify irregular and multiple inflammatory lesions hip. Methods: All SpA were enrolled at Xijing Hospital. The erythrocyte sediment rate (ESR), C-reactive protein (CRP), hip function Harris score, disease activity evaluated by clinicians. Manual MRI annotations including bone marrow...
A facile adsorbent, a nanocomposite of Fe3 O4 and reduced graphene oxide, was fabricated for the selective separation enrichment synthetic aromatic azo colorants by magnetic solid-phase dispersion extraction. The synthesized in one-step reduction reaction characterized atomic force microscopy, scanning electron Fourier transform infrared spectroscopy, Raman X-ray diffraction Brunauer-Emmett-Teller analysis. beverages were quickly adsorbed onto surface with strong π-π interactions between...