A5101504338- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Hepatitis C virus research
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Viral Infections and Immunology Research
- Cancer Research and Treatments
- Diet and metabolism studies
- Traditional Chinese Medicine Studies
- Respiratory viral infections research
- Liver physiology and pathology
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer-related gene regulation
- Medical Research and Treatments
- Cancer Genomics and Diagnostics
- Foot and Ankle Surgery
- Cancer Immunotherapy and Biomarkers
- Spondyloarthritis Studies and Treatments
- Cytokine Signaling Pathways and Interactions
- Healthcare and Venom Research
- Brain Tumor Detection and Classification
XinHua Hospital
2007-2025
Physical Sciences (United States)
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Hefei Institutes of Physical Science
2025
Macau University of Science and Technology
2025
Baoji City Central Hospital
2025
Shanghai Jiao Tong University
2010-2025
Northeast Agricultural University
2022-2024
Liaoning University
2024
Chinese PLA General Hospital
2006-2024
Background: Accurate glioma grading before surgery is of the utmost importance in treatment planning and prognosis prediction. But previous studies on MRI images were not effective enough. According to remarkable performance convolutional neural network (CNN) medical domain, we hypothesized that a deep learning algorithm can achieve high accuracy distinguishing World Health Organization (WHO) low grade gliomas. Methods: One hundred thirteen patients retrospectively included. Tumor segmented...
High moisture extrusion of soy protein concentrate (SPC) and wheat gluten (WG) blends was conducted to investigate the potential use this mixture in production meat analogs. Extrusion samples collected at different zones from extruder barrel extrudates were analyzed determine their texture, microstructure, solubility, secondary structure, mode disulfide bonds present molecular structure. Results obtained study indicate that a blend SPC-WG 50/50 resulted best fibrous structures. In...
// Xin Zhang 1, * , Lin-Feng Yan Yu-Chuan Hu 1 Gang Li 2 Yang Yu Han Ying-Zhi Sun Zhi-Cheng Liu Qiang Tian Zi-Yang 3 Le-De Bin-Quan Zi-Yu Qiu Wen Wang and Guang-Bin Cui Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi, P.R. China Neurosurgery, Student Brigade, 710032, These authors have contributed equally to this work Correspondence to: Cui, email: cgbtd@126.com Wang, wangwen@fmmu.edu.cn Keywords: glioma grading, MRI, machine...
Atherosclerotic renal artery stenosis (ARAS) raises blood pressure and can reduce kidney function. Revascularization of the stenotic alone does not restore medullary structure This study tested hypothesis that addition mesenchymal stem cells (MSC) to percutaneous transluminal angioplasty (PTRA) stenotic-kidney tubular transport function attenuate its remodeling. Twenty-seven swine were divided into three ARAS (high-cholesterol diet stenosis) a normal control group. Six weeks after induction,...
Abstract Aging is an important risk factor for cardiovascular diseases, and aging‐related cardiac dysfunction serves as a major determinant of morbidity mortality in elderly populations. Our previous study has identified fibronectin type III domain‐containing 5 (FNDC5) its cleaved form, irisin, the cardioprotectant against doxorubicin‐induced cardiomyopathy. Herein, aging or matched young mice were overexpressed with FNDC5 by adeno‐associated virus serotype 9 (AAV9) vectors, subcutaneously...
Development of underwater adhesives with instant and robust adhesion to diverse substrates remains challenging. A strategy taking the structural advantage phenylalanine derivative, N-acryloyl (APA), is proposed facilely prepare a series polymeric glue-type (UPGAs) through one-pot radical polymerization commonly used hydrophilic vinyl monomers. The adjacent phenyl carboxyl groups in APA realize synergy between interfacial interactions cohesion strength, by which UPGAs could achieve (~5...
Background: In cancer immunotherapy, gene therapy has become a promising strategy through the introduction of immunostimulatory components into its formulation. However, ideal non-viral delivery platforms capable simultaneously maintaining high efficiency and immune activation are still in demand. As an intestinal probiotic, Lactobacillus reuteri potential correlation with progression. Its unique antigenicity also confers immunomodulatory activity. Method: We engineered new siRNA system,...
Hepatocytes are critical for the maintenance of liver homeostasis, but its involvement in hepatic fibrogenesis remains elusive. Hepatocyte nuclear factor 1α (HNF1α) is a liver-enriched transcription that plays key role hepatocyte function. Our previous study revealed significant inhibitory effect HNF1α on hepatocellular carcinoma. In this study, we report expression significantly repressed both human and rat fibrotic liver. Knockdown aggravates either dimethylnitrosamine (DMN) or bile duct...
Abstract Background Local ischemia and defective osteogenesis are implicated in the progression of glucocorticoid (GC)-induced osteonecrosis femoral head (ONFH). Recent studies have revealed that exosomes released from adipose-derived stem cells (ASCs) play important roles ONFH therapy. The present study aimed to investigate whether derived miR-378-overexpressing ASCs (miR-378-ASCs-Exos) could promote angiogenesis GC-induced ONFH. Methods In vitro, we investigated osteogenic potential...
Background: To evaluate the feasibility of predicting tumor recurrence hepatocellular carcinoma (HCC) patients after curative hepatectomy by detection circulating DNA (ctDNA) through droplet digital PCR (ddPCR). Methods: HCC receiving surgical treatment were enrolled and peripheral blood samples before collected. Four hotspot mutants, TP53-rs28934571 (c.747G>T), TRET-rs1242535815 (c.1-124C>T), CTNNB1-rs121913412 (c.121A>G) CTNNB1-rs121913407 (c.133T>C) selected to detect ctDNA mutant allele...
Summary M etarhizium robertsii has been used as a model to study fungal pathogenesis in insects, and its pathogenicity many parallels with plant mammal pathogenic fungi. MAPK (Mitogen‐activated protein kinase) cascades play pivotal roles cellular regulation fungi, but their functions have not characterized . In this study, we identified the full complement of cascade components dissected regulatory pathogenesis, conidiation stress tolerance. The nine Fus3, Hog1 Slt2‐ are all involved...
Increasing evidence shows that static magnetic fields (SMFs) can affect cell proliferation but mixed results have been reported. Here we systematically examined the effects of 1 T (Tesla) SMF, which is close to SMF intensity patients are exposed MRI (magnetic resonance imaging) scanners in hospitals, for its effect on 15 different lines, including 12 human and 3 rodent lines. Our show does not apparent impact cycle or death. However, at higher density, it reduced numbers six out seven solid...
Aims: To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) resting-state magnetic resonance (rs-fMRI), respectively. Methods: Twelve T2DM MCI twenty-four age, sex, education matched healthy controls (HC) were recruited. DTI rs-fMRI data subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining...
Due to the wide application of engineered aluminum oxide nanoparticles and increased containing particulate matter suspending in air, exposure human nano-scale (Al2O3 NPs) is becoming inevitable.In present study, RNA microarray coupled with metabolomics analysis were used uncover mechanisms underlying cellular responses Al2O3 NPs imply potential rescue.We found that significantly triggered down-regulation mitochondria-related genes located complex I, IV V, which involved oxidative...
Though current pathological methods are greatly improved, they provide rather limited functional information. Cell-in-cell structures (CICs), arising from active cell-cell interaction, surrogates of complicated cell behaviors within heterogeneous cancers. In light this, we performed the subtype-based CIC profiling in human breast cancers by "EML" multiplex staining method, and accessed their values as prognostic factors Cox univariate, multivariate, nomogram analysis. CICs were detected...
Inflammation is typically related to dysfunction of the blood-brain barrier (BBB) that leads early brain injury (EBI) after subarachnoid hemorrhage (SAH). Resolvin D1 (RVD1), a lipid mediator derived from docosahexaenoic acid, possesses anti-inflammatory and neuroprotective properties. This study investigated effects mechanisms RVD1 in SAH. A Sprague-Dawley rat model SAH was established through endovascular perforation. RVD1was injected femoral vein at 1 12 h induction. To further explore...
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of proprotein family, functions as a classic regulator low-density lipoprotein (LDL) by interacting with receptor (LDLR). Recent studies have shown that PCSK9 can affect occurrence and development tumors be used novel therapeutic target. However, comprehensive pan-cancer analysis has yet to conducted. Methods The potential oncogenic effects in 33 types were explored based on datasets Cancer Genome...
trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim present study was investigate resveratrol hypertrophy vivo and potential underlying mechanisms involving endothelin (ET), angiotensin (Ang) II nitric oxide (NO) partially nephrectomized rats. Animal models bearing were replicated male Sprague-Dawley rats...