A5078838016- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Tea Polyphenols and Effects
- Food Allergy and Anaphylaxis Research
- Antioxidant Activity and Oxidative Stress
- Nuts composition and effects
- Animal Genetics and Reproduction
- Diet and metabolism studies
- Virus-based gene therapy research
- Toxic Organic Pollutants Impact
- Genetically Modified Organisms Research
- Viral Infectious Diseases and Gene Expression in Insects
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Nutrition, Genetics, and Disease
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Viral gastroenteritis research and epidemiology
- CAR-T cell therapy research
- Cardiac Fibrosis and Remodeling
- Metabolomics and Mass Spectrometry Studies
China National Center for Food Safety Risk Assessment
2016-2025
Sun Yat-sen University
2021-2025
Qingdao University
2025
Affiliated Hospital of Qingdao University
2025
China Agricultural University
2025
National University of Defense Technology
2022-2025
Academy of Military Medical Sciences
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Wuyi University
2024
Hebei Medical University
2022
Environmental cadmium, with a high average dietary intake, is severe public health risk. However, the long-term implications of environmental exposure to cadmium in different life stages remain unclear.
Early stage exposure of foodborne substances, such as brightening agent titanium dioxide nanoparticles (TiO2 NPs), can cause long-term effects in adulthood. We aimed to explore the potential adverse effect dietary intake TiO2 NPs. After feeding for 2-3 months from weaning, NPs-exposed mice showed lower body weight and induced intestinal inflammation. However, this phenomenon was not observed gut microbiota-removed mice. NPs rarely affected diversity microbial communities, but significantly...
Macrophage polarization is mainly steered by metabolic reprogramming in the tissue microenvironment, thus leading to distinct outcomes of various diseases. However, role lipid metabolism regulation macrophage alternative activation incompletely understood. Using human THP-1 and mouse bone marrow derived models, we revealed a pivotal for arachidonic acid determining phenotype M2 macrophages. We demonstrated that was inhibited acid, but inversely facilitated its metabolite prostaglandin E2...
Abstract Over the last decade, oncolytic virus (OV) therapy has shown its promising potential in tumor treatment. The fact that not every patient can benefit from it highlights importance for defining biomarkers help predict patients’ responses. As particular self-amplifying biotherapeutics, anti-tumor effects of OVs are highly dependent on host factors viral infection and replication. By using weighted gene co-expression network analysis (WGCNA), we found matrix remodeling associated 8...
Mounting evidence has shown that ambient PM2.5 exposure is closely associated with the development of obesity, and adipose tissue represents an important endocrine target for PM2.5. In this study, 3T3-L1 preadipocyte differentiation model was employed to comprehensively explore adipogenic potential After 8 days exposure, adipocyte fatty acid uptake lipid accumulation were significantly increased, cells promoted in a concentration-dependent manner. Transcriptome lipidome analyses revealed...
Phthalic acid esters (PAEs), commonly used as plasticizers, are pervasive in the environment, leading to widespread human exposure. The association between phthalate exposure and metabolic disorders has been increasingly recognized, yet precise biological mechanisms not well-defined. In this study, we explored effects of monoethylhexyl (MEHP) monocyclohexyl (MCHP) on glucose lipid metabolism hepatocytes adipocytes. hepatocytes, MEHP MCHP were observed enhance uptake accumulation a...
trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim present study was investigate resveratrol hypertrophy vivo and potential underlying mechanisms involving endothelin (ET), angiotensin (Ang) II nitric oxide (NO) partially nephrectomized rats. Animal models bearing were replicated male Sprague-Dawley rats...
Abstract Abstract: The effects of almond consumption on DNA damage and oxidative stress among cigarette smokers were studied. Thirty healthy adult male regular randomly divided into three groups, 10 subjects per group. Group A (control group) did not receive any almonds. Subjects in Groups B C received 3 oz 6 (84 g 168 g) almonds each day respectively for 4 wk. Two known biomarkers damage, urinary 8-hydroxy-2'-deoxyguanosine (8-OH-dG) single strand breaks peripheral blood lymphocytes,...
Oncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the treatment cancer. However, attenuation virulence, which is generally required development OVs based on pathogenic viral backbones, frequently accompanied by compromised killing effect tumor cells. By exploiting property to evolve and adapt in cancer cells, we perform directed natural evolution refractory colorectal cell HCT-116 generate next-generation oncolytic virus M1 (NGOVM) with an increase up...
Objective Many adolescents with non suicidal self injury disorder have ideation. However, the specific characteristics of NSSI-D that contribute to high suicide risk remain unclear. This study observes association between depressive and anxiety symptoms among disorder, explores mechanism underlying in this population. Method Adolescents their parents from a psychiatric outpatient clinic were selected conduct paper questionnaires measure sociodemographic conditions. The Mini International...
ABSTRACT Since the eradication of smallpox, zoonotic poxviruses, such as mpox virus (MPXV), continue to pose a threat public health. Identifying drugs that reduce poxvirus infection and replication, well understanding their molecular mechanisms, is essential for epidemic control. Polo‐like kinase 1 (PLK1) has been shown facilitate vaccinia (VACV) replication. This study confirms effects PLK1 inhibitors HMN‐214 ON‐01910 on VACV replication in A549 cells. Both viral titers DNA loads were...
Palytoxin (PTX), a toxin naturally synthesized by marine organisms like Palythoa, Ostreopsis and Trichodesmium spp. in tropical temperate seas, bioaccumulates fish crustaceans, thereby exposing humans through the food chain. Although growing evidence highlights PTX's lethal hepatotoxicity, nephrotoxicity, cardiotoxicity, its neurotoxic effects underlying mechanisms remain elusive. In this study, we assessed cerebral neurotoxicity of PTX using HT22 neuronal cells chronic mouse model,...
Abstract Earlier in its history, the Earth used to spin faster than it does today. How ancient organisms adapted short day/night cycles during that time remains unclear. In this study we reconstruct and analyse circadian clock system KaiABC (anKaiABC) of cyanobacteria existed ~0.95 billion years ago, when daily light/dark cycle was ~18 h-long. Compared their contemporary counterparts, anKaiABC proteins had different structures interactions. The kinase, phosphatase, adenosine triphosphatase...
Neodymium, as a strategic rare earth element (REE), has demonstrated bioaccumulative potential and can permeate human systems through inhalation of airborne particulates, ingestion contaminated food/water, dermal absorption from soil matrices, ultimately eliciting multi-organ toxicological manifestations. However, the hepatotoxicological profile neodymium species their pathophysiological mechanisms remain inadequately characterized. Neodymium nitrate (Nd(NO3)3), predominant water-soluble...