A5008892432- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Toxic Organic Pollutants Impact
- Electrocatalysts for Energy Conversion
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Genetic and phenotypic traits in livestock
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Bioactive Compounds and Antitumor Agents
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Immune cells in cancer
- Catalysis and Hydrodesulfurization Studies
- Air Quality and Health Impacts
- Neuroendocrine Tumor Research Advances
- Plant Molecular Biology Research
- Pediatric health and respiratory diseases
- Thyroid Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Peking Union Medical College Hospital
2024-2025
Peking University
2021-2025
Beijing University of Chemical Technology
2025
University of Amsterdam
2023-2024
Nanjing University of Chinese Medicine
2023-2024
Jiangsu Province Hospital
2023-2024
Anhui Medical University
2022-2024
UNSW Sydney
2024
Materials Science & Engineering
2024
Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO
Genome-wide association studies (GWAS) have been extensively used to identify genomic regions associated with a variety of phenotypic traits in pigs. Until now, most GWAS explored single-trait models. Here, we conducted both single- and multi-trait meta-analysis for nine fatness growth on 2004 pigs from four diverse populations, including White Duroc × Erhualian F2 intercross population Chinese Sutai, Laiwu populations. We identified 44 chromosomal that were the traits, genome-wide...
It's challenging work to identify disease-causing genes from the next-generation sequencing (NGS) data of patients with Mendelian disorders. To improve this situation, researchers have developed many phenotype-driven gene prioritization methods using a patient's genotype and phenotype information, or information only as input rank candidate's pathogenic genes. Evaluations these ranking provide practitioners convenience for choosing an appropriate tool their workflows, but retrospective...
Head and neck squamous cell carcinoma (HNSCC) is one of the most heavily immune infiltrated human tumors, having distinct subtypes associated with different molecular characteristics clinical outcomes. The tumor microenvironment (TME) HNSCC which was dominated by tumor-associated macrophages (TAMs) had a relatively inferior prognosis. High levels oxidized low-density lipoprotein receptor 1 (OLR1) expression are more aggressive metastatic in multiple cancers. However, link between OLR1...
Mounting evidence has shown that ambient PM2.5 exposure is closely associated with the development of obesity, and adipose tissue represents an important endocrine target for PM2.5. In this study, 3T3-L1 preadipocyte differentiation model was employed to comprehensively explore adipogenic potential After 8 days exposure, adipocyte fatty acid uptake lipid accumulation were significantly increased, cells promoted in a concentration-dependent manner. Transcriptome lipidome analyses revealed...
Reliable and comprehensive multi-omics analysis is essential for researchers to understand explore complex biological systems more completely. Bacillus subtilis (B. subtilis) a model organism Gram-positive spore-forming bacteria, in-depth insight into the physiology molecular basis of spore formation germination in this requires advanced multilayer data sets generated from same sample. In study, we evaluated two monophasic methods polar nonpolar compound extraction...
Abstract Immune checkpoint therapy (ICT) can produce durable antitumor responses in various cancer types; however, the are not universal, and predictive biomarkers urgently needed. Growing evidence points to a link between epigenetic regulation anti-tumor immunity, while clinical data on association of genomic alterations transcriptional dysregulation-related genes ICT benefit lacking. Histone–lysine N -methyltransferase 2 (KMT2) family proteins methylate lysine 4 histone H3 tail at...
Accumulating evidence has recognized that cancer-associated fibroblasts (CAFs) are major players in the desmoplastic stroma of ovarian cancer, modulating tumor progression and therapeutic response. However, it is unclear regarding signatures CAFs could be utilized to predict clinical outcomes cancer patients. To fill this gap, we explored intratumoral compartment by analyzing single-cell RNA-sequencing (scRNA-seq) datasets carcinoma samples, identified two distinct (tumor-promoting CAF_c1...
It is generally recognized that phenol-containing molecules mainly undergo phase II metabolic reactions, whereas glucuronide and sulfate are conjugated to form water-soluble products. Here, we report direct reactions of phenolic pollutants (triclosan, alkylphenol, bisphenol A [BPA], its analogues) some endogenous metabolites (vitamin E [VE] estradiol) generate new lipophilic ether products (e.g., BPA-O-VEs alkylphenol-O-estradiol). nontargeted screening strategy was used identify the in...
ABSTRACT The immune response induced by respiratory syncytial virus (RSV) infection is closely related to changes in the composition and function of gastrointestinal microorganisms. However, specific mechanism remains unknown pulmonary-intestinal axis deserves further study. In this study, mRNA levels ROR-γt Foxp3 lung intestine increased first then decreased. IL-17 IL-22 reached maximum on third day after lung, second small colon, respectively. RegⅢγ intestinal tissue RSV infection....
Chlorinated paraffins (CPs) are manufactured and used in high quantities have diverse structural analogues. It is generally recognized that sulfur-containing analogues of CPs mainly derived from sulfate-conjugated phase II metabolism. In this study, we non-targeted identified three classes CP (CPs–S) human serum, including 44 sulfates (CPs–SO4H/CPs–SO4H–OH), 14 chlorinated benzene (CBs–SO4H), 19 sulfite esters (CPs–SO3/CPs–S2O6), which were generated during the production commercial mixtures...
The energy demand has increased significantly in recent years and it is urgent to develop a renewable system that highly efficient non-noble metal-based. Hydrogen an environmentally friendly source with abundant resources, which can be used solve the problem of high without greenhouse gas emissions. However, development catalysts for hydrogen production technology by electrolysis water slow, mainly due complexity generation process, low efficiency, weak electrode material activity cost....
Abstract Exploring low‐iridium (Ir) electrocatalysts for oxygen evolution reaction (OER) is exigent to promote the commercialization of proton electrolyte membrane water electrolyzers (PEMWEs). Herein, study presents a scalable and facile strategy in situ construct an IrO x nanofilm continuously coated on TiO support as efficient durable OER catalyst through one‐step annealing Ir‐salt‐adsorbed titanium‐based metal–organic frameworks (MOFs) precursor. The unique structure forms continuous p‐n...
Estrogen, being an essential class of sex hormone, is important target endocrine disruption chemicals. It well known that environmental disruptors could activate or inhibit estrogen receptors, acting as agonists antagonists, and thus affect the circulating concentrations. Here, we report enzyme-mediated diradical cross-coupling reactions between alkylphenols (e.g., 2,4-di-tert-butylphenol [DBP], 4-nonylphenol [4-NP], 4-tert-octylphenol [4-t-OP]) estrogens estradiol [E2]) generate coupling...
Abstract Respiratory syncytial virus (RSV) infects neuronal cells in the central nervous system (CNS), resulting neurological symptoms. In present study, we intended to explore mechanism of RSV infection‐induced neuroinflammatory injury from perspective immune response and sought identify effective protective measures against injury. The findings showed that toll‐like receptor 4 (TLR4) was activated after infection human SY5Y cells. Furthermore, TLR4 activation induced autophagy apoptosis...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common worldwide, and increasing evidence suggests that exposure to environmental pollutants associated with increased incidence of MASLD. The farnesoid X receptor (FXR) plays an important role in development MASLD by regulating bile acids (BAs) lipid metabolism. However, whether FXR-active are drivers remains unclear. This study aimed determine exist environment evaluate their ability trigger mice. An FXR protein...