Metformin has been used for the treatment of type 2 diabetes by suppressing hepatic gluconeogenesis. It shown that subclinical inflammatory responses play important roles in pathogenesis diabetes. In present study, we determined effects metformin on levels pro-inflammatory cytokines (i.e., IL-6, TNF-α, and MCP-1) anti-inflammatory mediator IL-10 blood urine patients with There were 210 diabetes, which randomized into (n = 112) non-metformin (gliclazide, acarbose, repaglinide, n 98) groups....

ABSTRACT The immune response induced by respiratory syncytial virus (RSV) infection is closely related to changes in the composition and function of gastrointestinal microorganisms. However, specific mechanism remains unknown pulmonary-intestinal axis deserves further study. In this study, mRNA levels ROR-γt Foxp3 lung intestine increased first then decreased. IL-17 IL-22 reached maximum on third day after lung, second small colon, respectively. RegⅢγ intestinal tissue RSV infection....

Abstract Background Thin endometrial thickness (EMT) has been suggested to be associated with reduced incidence of pregnancy rate after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment, but the effect thin endometrium on obstetric outcome is less investigated. This study aims determine whether EMT affects complications fresh IVF/ICSI-embryo transfer (ET) cycles. Methods We conducted a retrospective cohort collecting total 9266 women who had singleton livebirths...

Abstract Respiratory syncytial virus (RSV) infects neuronal cells in the central nervous system (CNS), resulting neurological symptoms. In present study, we intended to explore mechanism of RSV infection‐induced neuroinflammatory injury from perspective immune response and sought identify effective protective measures against injury. The findings showed that toll‐like receptor 4 (TLR4) was activated after infection human SY5Y cells. Furthermore, TLR4 activation induced autophagy apoptosis...

Diabetes mellitus is associated with prothrombotic states and thrombotic events. This study examined the association between preoperative glucose levels deep vein thrombosis (DVT) in trauma patients undergoing surgery for lower limb fracture. Data from 1,591 who underwent fracture January 2017 March 2022 at Affiliated Hospital of Qingdao University were queried institutional electronic medical records. A total population 1,086 was identified, comprising 138 experienced DVT 948 controls. The...

Type 2 diabetes is often associated with arterial atherosclerosis in large blood vessels. We set out to elucidate whether commonly used antidiabetic drugs metformin, sitagliptin, and pioglitazone will reduce T2DM patients. enrolled 176 individuals type diabetes, which were divided into four treatment groups according different oral drugs: metformin alone, sitagliptin or combination of sitagliptin. assessed changes glycometabolism, lipid metabolism, cytokine released, carotid artery...

Objectives Postoperative major bleeding is a common problem in patients undergoing cardiac surgery and associated with poor outcomes. We evaluated the performance of machine learning (ML) methods to predict postoperative bleeding. Methods A total 1,045 who underwent isolated coronary artery bypass graft (CABG) were enrolled. Their datasets assigned randomly training (70%) or testing set (30%). The primary outcome was defined as universal definition perioperative (UDPB) classes 3–4....

Window functions have been a part of the SQL standard since 2003 and studied extensively during past decade. They are widely used in data analysis; almost all current mainstream commercial databases support window functions. However, recent years size datasets is growing steeply; existing function implementations not efficient enough. Recently, some sampling-based algorithms (e.g., online aggregation) proposed to deal with large complex relational databases, which offer us flexible trade-off...

Since the performance of pyramid Lucas-Kanade (LK) based optical flow algorithm would be influenced by different environments, this paper evaluates simulation accuracy LK in cities, plains and mountains, respectively. The results show that can maintain high precision under large motion, flight strategy UAV environment is given according to algorithm's accuracy, In order ensure sensor environments. For example, urban environment, when UAV's velocity 12m/s-15m/s, best altitude 80m-150m....

Abstract To enhance the small cruise vehicle in complex environment under ice autonomous obstacle avoidance ability, artificial potential field algorithm was improved this paper. Firstly, idea and principle of traditional as well its existing defects such local minimum are analyzed. Then defect method is solved by optimizing repulsive function adjusting force component’s direction on coordinate axis. Then, simulated using MATLAB software. The experimental results show that can make cruiser...

Objective: The objective of this study was to provide a descriptive analysis the clinical outcomes achieved in oocyte vitrification cases where sperm unavailable on retrieval day, and identify predictors survival. Methods: This retrospective cohort used data from university-affiliated reproductive medical center. There were 321 cycles which some of, or all oocytes vitrified owing unavailability between March 2009 October 2017. A including both fresh embryo transfers cryopreserved provided....

Evolutionary circuit is an important part of electronic design automation. It a kind automatic system by intelligent algorithm, widely used in robot controller design, and other fields. Compared with algorithms, Particle Swarm Optimization (PSO) has better performance the process evolution, but it disadvantage falling into local optimum easily during resulting meaningless increase computing resources. This paper proposes hybrid algorithm based on Ising model PSO for optimizing combinational...

As the video detection technology has become a hot issue in Intelligent Transportation System (ITS), detecting moving vehicles accurately real-time is one of challenging problems. This paper describes method for segmenting dynamic scenes. An adaptive background update algorithm based on three-frame difference proposed. By this method, updated according to change surrounding light and external events. Meanwhile, acquiring an accurate whole segmentation result, threshold which could adapt...

Abstract Previous research results of our group showed that Toll‐like receptor 4 (TLR4) and nucleolin synergistically mediate respiratory syncytial virus (RSV) infection in human central neuron cells, but the specific mechanism remains unclear. Here we designed synthesized lentiviruses with TIR (674–815 aa), TLR4 (del 674–815 GAR (645–707 NCL 645–707 aa) domains, obtained stable overexpression cell lines by drug screening, subsequently infected RSV at different time points. Laser confocal...

In order to better suit the continuous development of medical environment and protect image security, a novel region interest (ROI) encryption scheme based on two-dimension discrete wavelet transform (2-D DWT) five-dimension hyperchaotic system is proposed. this paper, first separated into ROI background area, one low frequency three high components in horizontal(H), vertical(V) diagonal(D) directions are obtained via 2-D DWT. Next, only component which approximate original scrambled spread...

Background based coding is an effective scheme to improve the efficiency of surveillance videos. However, it takes a long time generate high quality background picture (BG-picture). And encoding BG-picture will increase bitrate abruptly. To solve these problems, progressive updating proposed in this paper. In scheme, updated block by block. overall efficiency, importance map designed select valid blocks (B-blocks) progressively which be encoded with quality. It worth noting that only...

Summary form only given. Motion compensation is the key technique to reduce temporal redundancy in video coding. Interpolation filters are adopted generate inter frame prediction for motion with fractional pixel accuracy. In existing coding standards such as H.264/AVC and HEVC, a set of predefined interpolation compensation. However, cannot adapt content, which may compromise efficiency. this paper, content adaptive scheme proposed scheme, derived each additional minimize difference....