A5101556159- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Hearing Loss and Rehabilitation
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Ginseng Biological Effects and Applications
- Hearing Impairment and Communication
- Lymphatic System and Diseases
- Hearing, Cochlea, Tinnitus, Genetics
- Liver physiology and pathology
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Alkaloids: synthesis and pharmacology
- Click Chemistry and Applications
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Calcium signaling and nucleotide metabolism
- Speech and Audio Processing
- Hepatocellular Carcinoma Treatment and Prognosis
- Cyclopropane Reaction Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- MRI in cancer diagnosis
Yale University
2020-2025
China Pharmaceutical University
2017-2025
Shanghai Normal University
2025
Sun Yat-sen University
2010-2025
Hubei University of Chinese Medicine
2024
Southeast University
2024
Nanjing Agricultural University
2023
Tianjin University
2023
Huazhong Agricultural University
2022
First Affiliated Hospital of Guangzhou Medical University
2021-2022
Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression fibrosis and cirrhosis responsible its clinical complications. Here, we have mapped spatial distribution heterogeneous ECs in normal vs cirrhotic mouse livers identified zone-specific transcriptomic changes LSECs associated with using scRNA-seq technology.
Rationale: Glucagon is involved in hepatic gluconeogenesis, playing a key role type 2 diabetes.Ginsenosides are reported to have antidiabetic activities.Ginsenoside Rg1 major propanaxatriol-type saponin ginseng.This study aims investigate the regulatory effects of on glucagon-induced glucose production.Methods: The were investigated high-fat-diet (HFD)-fed mice and glucagon-challenged C57BL/6J mice.Glucose metabolism was evaluated by oral tolerance test pyruvate test.The regulation Akt-FoxO1...
Abstract Hexokinase-II (HK-II) and dynamin-related protein 1 (Drp1) regulate mitochondrial function differently. This study was designed to investigate the cardioprotective effect of ginsenoside Rg5 (Rg5) with emphasis on regulation HK-II Drp1. Saturated acid palmitate (PA) stimulation increased lactate accumulation induced cellular acidification by impairing activity pyruvate dehydrogenase (PDH) in cardiomyocytes, leading dissociation from mitochondria. improved PDH prevented combating...
Abstract Altered mitochondrial metabolism acts as an initial cause for cardiovascular diseases and metabolic intermediate succinate emerges a mediator of dysfunction. This work aims to investigate whether or not extracellular accumulation its targeted G protein-coupled receptor-91 (GPR91) activation induce cardiac injury through impairment. The results showed that promoted the translocation dynamin-related protein 1 (Drp1) mitochondria via kinase Cδ (PKCδ) activation, induced fission factor...
Aims: Pulmonary fibrosis (PF) is characterized by myofibroblast activation through oxidative stress. However, the precise regulation of transdifferentiation remains largely uncharacterized. Results: In this study, we found that tanshinone IIA (Tan-IIA), an active component in root Salvia miltiorrhiza Bunge, can suppress reactive oxygen species (ROS)-mediated and reduce extracellular matrix deposition bleomycin (BLM)-challenged mice nuclear factor-erythroid 2-related factor 2 (Nrf2)....
Abstract Background Exploration of adaptive evolutionary changes at the genetic level in vaginal microbial communities during different stages cervical cancer remains limited. This study aimed to elucidate mutational profile microbiota throughout progression disease and subsequently establish diagnostic models. Methods utilized a metagenomic dataset consisting 151 subjects classified into four categories: invasive (CC) ( n = 42), intraepithelial neoplasia (CIN) 43), HPV-infected (HPVi)...
Endoplasmic reticulum (ER) stress, inflammation and lipolysis occur simultaneously in adipose dysfunction contribute to insulin resistance. This study was designed investigate whether ginsenoside Rg5 could ameliorate prevent muscle Short-term high-fat diet (HFD) feeding induced hypoxia with ER stress tissue, leading succinate accumulation due the reversal of dehydrogenase (SDH) activity. treatment reduced cellular energy charge, suppressed then prevented tissue. Succinate promoted IL-1β...
Abstract The liver lymphatic system plays a critical role in maintaining interstitial fluid balance and immune regulation. Efficient drainage is essential for homeostasis, but its disease progression remains poorly understood. In cirrhosis, lymphangiogenesis initially compensates increased lymph production, impaired advanced stages may lead to complications such as ascites portal hypertension. This study aimed evaluate how dysfunction affects assess therapeutic strategies. Using surgical...
Word stress is a fundamental aspect of English pronunciation that significantly influences comprehension in spoken communication. Despite its importance, many Chinese learners find it hard to master the nuanced patterns distinguish stressed from unstressed syllables, particularly regarding vowel production, topic studied by few researchers. Therefore, this study aims explore impact word on system through an experimental analysis. Twenty disyllabic words with one and syllable were analyzed....
ABSTRACT Background The liver undergoes significant hemodynamic changes during surgery, transplantation, or cirrhosis with portal hypertension(PH). hepatic artery buffer response(HABR), which compensates for reduced venous flow by increasing artery(HA) flow, is hypothesized to induce pathological tract remodeling. This study investigates the molecular mechanisms underlying this process. Methods PH was induced in Sprague-Dawley rats via partial vein ligation(PPVL). Structural...
Abstract Earlier in its history, the Earth used to spin faster than it does today. How ancient organisms adapted short day/night cycles during that time remains unclear. In this study we reconstruct and analyse circadian clock system KaiABC (anKaiABC) of cyanobacteria existed ~0.95 billion years ago, when daily light/dark cycle was ~18 h-long. Compared their contemporary counterparts, anKaiABC proteins had different structures interactions. The kinase, phosphatase, adenosine triphosphatase...
The lymphatic system plays crucial roles in maintaining fluid balance and immune regulation. Studying the liver lymphatics has been considered challenging, as common endothelial cell (LyEC) markers are expressed by other cells. Additionally, isolation of sufficient numbers LyECs challenging because their extremely low abundance (<0.01% entire population) a normal liver.
Abstract Objective To study the extent and severity of macrovasculopathy in systemic sclerosis (SSc; scleroderma) patients by comparing both local regional arterial stiffness parameters. Methods The indices right common carotid artery, brachial radial superficial femoral posterior tibial artery were measured 25 SSc strictly matched healthy controls. pulse wave velocity (PWV) each segment was also calculated from intensity analysis. Results There no differences between two groups index (β),...
Drought is a major environmental stress that severely affects plant growth and crop productivity. FRIGIDA (FRI) key regulator of flowering time drought tolerance in model plants. However, little known regarding its functions woody plants, including citrus. Thus, we explored the functional role citrus FRI ortholog (CiFRI) under drought. treatment induced CiFRI expression. overexpression enhanced transgenic Arabidopsis citrus, while suppression increased susceptibility Moreover, transcriptomic...
Selective structural modification of amino acids and peptides is a central strategy in organic chemistry, chemical biology but also pharmacology material science. In this context, the formation tetrazole rings, known to possess significant therapeutic properties, would expand space unnatural has received less attention. study, we demonstrated that classic unimolecular Wolff rearrangement α-amino acid-derived diazoketones could be replaced by faster intermolecular cycloaddition reaction with...
Checkpoint inhibitor-related pneumonitis (CIP) is a lethal immune-related adverse event. However, the development process of CIP, which may provide insight into more effective management, has not been extensively examined. We conducted multicenter retrospective analysis 56 patients who developed CIP. Clinical characteristics, radiological features, histologic and laboratory tests were analyzed. After comprehensive analysis, we proposed acute, subacute, chronic phases CIP summarized each...
In the past decade, cleavage protein irisin derived from fibronectin type III domain-containing 5 (FNDC5) in exercise-stimulated skeletal muscle has increasingly become a biomarker associated with metabolic syndrome and osteoporosis humans. However, it is unclear how this facilitates muscle-adipose-bone connectivity homeostasis. study, we unexpectedly observed that FNDC5 gene can be markedly activated during differentiation of brown adipocytes but not white adipocytes, specifically expressed...
Abstract The general odorant‐binding proteins (GOBPs) in Lepidoptera form a distinct OBP subclass, which exclusively has two members (GOBP1 and GOBP2) single species. GOBPs are long thought to function perception of plant odorants recently sex pheromones, but the vivo evidence is rarely provided. Here, by using CRISPR/Cas9 technique, we demonstrated that GOBP1 noctuid moth Spodoptera litura involved host volatiles not female pheromone, females less important than GOBP2 perception. First,...
This article showed a comprehensive 3-D-structural analysis of liver lymphatic vessel (LV) in normal and diseased livers relation to blood vessels bile ducts. In addition the LVs highly localized at portal tract, we revealed capsular mouse, rat, human livers. cholestatic livers, are significantly increased dilated compared with Our optimized protocol provides detailed spatial information for remodeling pathological conditions.